FK866 (APO866, Daporinad)
658084-64-1
99%
Bottle,barrel,cargo,container,etc.
2026-10-11
Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals
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Product Description
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Seller Information
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DescriptionHANGZHOU LEAP CHEM CO., LTD., with approximately 1815650 visits to its shop, is a reputable Trader that has been providing FK866 (APO866, Daporinad) products for 5 years on ECHEMI.ECHEMI Editorial ReferenceFK866 is an effective inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase) with an IC50 of 0.09 nM.
N-[4-(1-benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2-propenamide is a member of benzamides and a N-acylpiperidine.|Daporinad has been used in trials studying the treatment of Melanoma, Cutaneous T-cell Lymphoma, and B-cell Chronic Lymphocytic Leukemia.|Daporinad is a small molecule with potential antineoplastic and antiangiogenic activities. Daporinad binds to and inhibits nicotinamide phosphoribosyltransferase (NMPRTase), inhibiting the biosynthesis of nicotinamide adenine dinucleotide (NAD+) from niacinamide (vitamin B3), which may deplete energy reserves in metabolically active tumor cells and induce tumor cell apoptosis. In addition, this agent may inhibit tumor cell production of vascular endothelial growth factor (VEGF), resulting in the inhibition of tumor angiogenesis. The coenzyme NAD+ plays an essential role in cellular redox reactions, including the redox reaction linking the citric acid cycle and oxidative phosphorylation.
Daporinad (FK866, APO866) effectively inhibits nicotinamide phosphoribosyltransferase (NMPRTase) with IC50 of 0.09 nM in a cell-free assay. Phase 1/2.
FK-866 is a highly specific non-competitive inhibitor of Nampt (Ki= 0.4 nM), causing gradual NAD+depletion. In HepG2 human liver carcinoma cells, NAD+depletion by FK-866 directs delayed cell death by apoptosis (IC50= ~1 nM). In normal human smooth muscle cells, FK-866 causes premature senescence, an effect that may be linked to decreased activity of the NAD+-dependent enzyme SIRT1. Also, FK-866 induces autophagy in SH-SY5Y neuroblastoma cells, as indicated by the formation of LC3-positive vesicles.
ChEBI: FK-866 is a member of benzamides and a N-acylpiperidine.Basic Info-
Product Name:
(E)-N-[4-(1-BENZOYL-PIPERIDIN-4-YL)-BUTYL]-3-PYRIDIN-3-YL-ACRYLAMIDE
Other Name:(E)-N-[4-(1-BENZOYL-PIPERIDIN-4-YL)-BUTYL]-3-PYRIDIN-3-YL-ACRYLAMIDE;2-PROPENAMIDE, N-[4-(1-BENZOYL-4-PIPERIDINYL)BUTYL]-3-(3-PYRIDINYL)-, (2E)-;APO-866;K 22.175;(2E)-N-[4-(1-Benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2-propenamide;FK 866;FK866 (APO866);FK866, >=98%
CAS No.:658084-64-1
Molecular Formula:C24H29N3O2
InChIKeys:KPBNHDGDUADAGP-VAWYXSNFSA-N
Molecular Weight:391.51
Exact Mass:391.51
UNII:V71TF6V9M7
NCI Thesaurus Code:C67043
Color/Form:white to beige
HScode:2933399990
Categories:
Characteristics-
PSA:
62.3
XLogP3:3.7
Appearance:white to beige
Density:1.131
Boiling Point:629.9±51.0 °C(Predicted)
Flash Point:334.8±30.4 °C
Refractive Index:1.589
Water Solubility:DMSO: soluble10mg/mL, clear
Storage Conditions:-20°C
PKA:14.12±0.46(Predicted)
Critical Temperature & Pressure:-20°C
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals
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Location:
Room A, 23rd Floor, No. 609 Yan'an Road, Gongshu District, Hangzhou, Zhejiang
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Payment Terms:
TT against copy of documents,D/P,L/C
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Average lead Time:
5
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Total Annual Revenue:
Above $100 million
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Year of Establishment:
2020
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Certifications:
ISO
">Company ProfileLEAPChem is a specialized fine chemical supplier for research, development and production.
LEAPChem provides nearly 200,000 rare and innovative chemical products to support the evolving needs of our customers in research & bulk manufacturing activities.
As a highly customer-oriented enterprise, we are committed to providing high-quality customer services and products to our global customers in a cost-effective and efficient manner.
Our client list includes many major pharmaceutical and science companies, universities, research institutions and chemical catalogue companies.
Methodology: Sound & Stable; Active & Innovative.
Attitude: Conscientious; Ingenious.
Goals: Customer's Satisfaction
We regard client's success as our success.
At LEAPChem, we strive to be the preferred supplier for efficiency increasing and cost lowering in your Research & Production.
To achieve this strategic vision, we always push ourselves to exceed our customer's requirement. By focusing on the aim of 'Beyond Your Expectation', we continually expand our product lines, and enhance our systematic management and human resources.
Welcome to contact us and we look forward to becoming your reliable and preferred partner.
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