Native Equine Butyrylcholinesterase
9001-08-5
2026-08-29
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName Native Equine Butyrylcholinesterase Cat No NATE-0092 Description Butyrylcholinesterase (BChE) is a serine hydrolase that is structurally similar to acetylcholinesterase (AChE), but differs in substRate specificities and inhibitor sensitivities. BChE can, unlike AChE, efficiently hydrolyze larger esters of choline such as butyrylcholine and benzoylcholine. The enzyme is a tetrameric glycoprotein with four equal subunits (110 kDa each). The enzyme is activated by Ca2+ and Mg2+ and the activity is constant over the pH range 6.0-8.0. It is inhibited by Betaine, nicotine, organophosphates, carbamates. Abbr BCHE, Native (Equine) Alias BCHE; BuChE Source Equine serum Species Equine Applications Butyrylcholinesterase from equine serum has been used in a microcalorimetric study of the inhibition of butyrylcholinesterase by paraoxon. This enzyme has also been used in a study to investigate the synthesis and inhibition of cholinergic enzymes. Selective inhibition of BChE activity can be used in the detection of organophosphates. Its use in the treatment of organophosphate toxicity has shown clinical potential, as there is a correlation between the blood level of BChE in humans and the degree of protection against toxic nerve agents. There has also been an interest in the roles of cholinesterases with regard to Alzheimer’s disease. Investigations into selective inhibitors may provide a clearer picture of the physiological role of BChE in both healthy and diseased individuals. This product has been used for the screening of cholineesterase inhibitors in selected fruits and vegetables, for restoring cognitive function and improving memory. It has also been used to develop a butyrylcholinesterase and choline oxidase immobilized bio-sniffer for the detection of nicotine. Nicotine inhibits BChE activity. A decrease in the byproducts of BChE activity reflects the volume of nicotine. Product Overview This product is prepared from equine serum using ammonium sulfate fractionation and supplied as a lyophilized powder. Form lyophilized powder; Highly purified; contains buffer salts Enzyme Commission Number EC 3.1.1.8 Activity Type 1, > 10 units/mg protein; Type 2, > 500 units/mg protein; Type 3, > 300 units/mg protein; Type 4, > 900 units/mg protein CAS No 9001-08-5 Molecular Weight Mr ~440 kDa Unit Definition One unit will hydrolyze 1.0 μmole of butyrylcholine to choline and butyrate per min at pH 8.0 at 37°C. The activity obtained using butyrylcholine as substrate is ~2.5 times that obtained using acetylcholine. Storage −20°C Buffer cold water: soluble 60 U/mL Function These findings show that BCHE can hydrolyze 2-Arachidonoylglycerol which may be evidence of a more specific role for BCHE in endocannabinoid regulation. Data indicate that polyproline peptides of various lengths and sequences are included in the tetramer structure of butyrylcholinesterase, and the function of these polyproline peptides is to serve as tetramer-organizing peptides. proline-rich peptides organize the 4 subunits of BChE into a 340 kDa tetramer, by interacting with the C-terminal BChE tetramerization domain Synonyms Butyrylcholinesterase; BCHE; BuChE; pseudocholinesterase; plasma cholinesterase; EC 3.1.1.8; 9001-08-5; Acylcholine acyl-hydrolase; Choline esterase; butyryl category Enzymes and Coenzymes Drugs(c1513) cas_num 9001-08-5 Basic Info-
Product Name:
Cholinesterase
Other Name:Cholinesterase;Esterase,choline;E.C. 3.1.1.8;Choline esterase;Butyrylcholinesterase;Pseudocholinesterase;E.C. 3.1.1.9;Benzoylcholinesterase;EC 3.1.1.8;Esterase,butyrylcholine;Propionylcholinesterase;Butyrylcholine esterase;Acylcholine acylhydrolase;Protexia;BtChoEase;Choline esterase II;Cholinesterase II;Butyrylcholine esterases;Benzoylcholinesterases;Acylcholine acylhydrolases;Propionylcholinesterases;Cholinesterases;Choline esterases;Butyrylcholinesterases;Pseudocholinesterases;BCHE;9014-15-7;9026-01-1
CAS No.:9001-08-5
EC Number:232-579-2
Categories:
Characteristics-
Appearance:
light brown powder
Melting Point:177-178.1 °C @ Solvent: Ligroine
Storage Conditions:2-8°C
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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