Native Porcine Catechol-O-methyl Transferase
9012-25-3
Yes
2026-11-07
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName Native Porcine Catechol-O-methyl Transferase Cat No NATE-0148 Description Catechol-O-methyltransferase (COMT; EC 2.1.1.6) is one of several enzymes that degrade catecholamines such as dopamine, epinephrine, and norepinephrine. In Humans, catechol-O-methyltransferase protein is encoded by the COMT gene. As the regulation of catecholamines is impaired in a number of medical conditions, several pharmaceutical drugs target COMT to alter its activity and therefore the availability of catecholamines. COMT was first discovered by the biochemist Julius Axelrod in 1957. Abbr COMT, Native (Porcine) Alias COMT; COMT I; COMT II Source Porcine liver Species Porcine Form Lyophilized powder containing phosphate buffer and dithiothreitol Enzyme Commission Number EC 2.1.1.6 Activity > 150 units/mg protein CAS No 9012-25-3 Unit Definition One unit will produce 1.0 nanomole of total O-methylated products from 3,4 dihydroxyacetophenone per hour at pH 7.6 at 37°C. Previous radioactive assay unit definition: One unit will catalyze the methylation of 1.0 nanomole of protocatechuic acid per hr at pH 7.9 at 37°C using S-adenosyl-L-[methyl-14C]methionine as the methyl donor. (~6 radioactive units equal one new unit). Synonyms catechol O-methyltransferase; COMT; COMT I; COMT II; S-COMT (soluble form of catechol-O-methyltransferase); MB-COMT (membrane-bound form of catechol-O-methyltransferase); catechol methyltransferase; catecholamine O-methyltransferase; EC 2.1.1.6; 9012-25-3; Pyrocatechol-O-methyl Transferase; S-Adenosyl-L-methionine:catechol O-methyltransferase pub_title Toxicological evaluation and metabolism of two N-alkyl benzamide umami flavour compounds: N-(heptan-4-yl)benzo[d][1,3]dioxole-5-carboxamide and (R)-N-(1-methoxy-4-methylpentan-2-yl)-3,4-dimethylbenzamide pub_url https://www.sciencedirect.com/science/article/pii/S2214750016300865?via%3Dihub category Amino Acids and Derivatives(c1517) cas_num 9012-25-3 ECHEMI Editorial ReferenceAny of a class of enzymesthat catalyze the transfer of a methyl group toan organic molecule. The methyl donor is s-adenosylmethionine, formed from methionine andATP.Basic Info-
Product Name:
Catechol O-methyltransferase
Other Name:Catechol O-methyltransferase;Methyltransferase,catechol;Catechol methyltransferase;E.C. 2.1.1.6;Catecholamine O-methyltransferase;Catechol O-methyltransferases;EC 2.1.1.6;S-Adenosyl-L-methionine:catechol O-methyltransferase;COMT;S-Adenosyl-L-methionine:catechol O-methyltransferases;Catecholamine O-methyltransferases;Catechol methyltransferases;9036-45-7;9041-66-1
CAS No.:9012-25-3
Exact Mass:636.496521
EC Number:232-727-6
Categories:
Characteristics-
XLogP3:
7.50
Appearance:lyophilized powder
Density:1.0±0.1 g/cm3
Boiling Point:771.4±40.0 °C at 760 mmHg
Flash Point:227.5±20.8 °C
Refractive Index:1.507
Storage Conditions:−20°C
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15 days
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
