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AZD8931

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CAS No.:

848942-61-0

Content:

99%

Price valid (until):

2026-07-20

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Creative Enzymes

Company Type:

Manufactory

Location:

United States

Qualification:

Main Products:

Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase

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Product Description
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Description

ProductName	AZD8931
Cat No	CEI-0064
Description	AZD8931 can inhibit EGFR and Erbb2 with IC50 of 12 nM and 14 nM.
CAS No	848942-61-0
Molecular Weight	473.93
Purity	>99%
Storage	2 years at -20 centigrade
Targets	EGFR, Erbb2
Molecular Formula	C23H25ClFN5O3
Chemical Name	2-(4-(4-(3-chloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)-N-methylacetamide
Solubility	DSMO 40 mg/mL Water
In vitro	AZD8931 can inhibit EGFR and Erbb2 with IC50 of 12 nM and 14 nM. AZD8931 has equipotent activity against signaling by three members of this family (epidermal growth factor receptor, erbB2, and erbB3). AZD8931 shows simultaneous, potent inhibition and delivers greater antitumor activity in experimental models than standard agents such as gefitinib or lapatinib. AZD8931 was the most potent inhibitor of erbB2 (IC50, 3 nmol/L) and erbB3 (IC50, 4 nmol/L) phosphorylation and was significantly more potent that either gefitinib or lapatinib for both erbB2.
In vivo	Oral dosing of AZD8931 significantly inhibited BT474c (breast), Calu-3 (NSCLC), LoVo (colorectal), FaDu (SCCHN), and PC-9 (NSCLC) tumor xenograft growth. AZD8931 causes pharmacodynamic changes in proliferation and apoptosis markers in human tumor xenograft models.
category	Inhibitors(c1514)
cas_num	848942-61-0

Basic Info

Product Name:

Sapitinib

Other Name:

1-Piperidineacetamide,4-[[4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-N-methyl-;4-[[4-[(3-Chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-N-methyl-1-piperidineacetamide;4-(3-Chloro-2-fluoroanilino)-7-methoxy-6-[[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy]quinazoline;AZD 8931;Sapitinib;Sapatinib;2-[4-[4-(3-Chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]-N-methylacetamide

CAS No.:

848942-61-0

Molecular Formula:

C23H25ClFN5O3

InChIKeys:

InChIKey=DFJSJLGUIXFDJP-UHFFFAOYSA-N

Molecular Weight:

473.9277032

Exact Mass:

473.93

EC Number:

-0

Categories:

Inhibitors

Characteristics

PSA:

88.6

XLogP3:

Density:

1.3±0.1 g/cm3

Boiling Point:

632.8±55.0°C at 760 mmHg

Flash Point:

336.5±31.5 °C

Refractive Index:

1.627

See More Sapitinib Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Oral

Reproductive toxicity, Category 1B

Specific target organ toxicity â repeated exposure, Category 1

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H302 Harmful if swallowed H360 May damage fertility or the unborn child H372 Causes damage to organs through prolonged or repeated exposure
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P203 Obtain, read and follow all safety instructions before use. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P260 Do not breathe dust/fume/gas/mist/vapours/spray.
Response	P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P318 IF exposed or concerned, get medical advice. P319 Get medical help if you feel unwell.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Sapitinib Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase

Location:
Shirley, New York 11967, USA

Payment Terms:
TT against copy of documents,D/P

Average lead Time:
15

Total Annual Revenue:
$1 million-$2.5 million

Year of Establishment:
2004

Creative Enzymes is a leading Manufactory supplier of Proline dipeptidase, Glucoamylase, BenzaMide, N-1H-pyrrolo[2,3-c]pyridin-5-yl- based in America. With a commitment to quality and customer satisfaction, Creative Enzymes has become a trusted name in the industry. Our product line includes a range of high-quality Proline dipeptidase, Glucoamylase, BenzaMide, N-1H-pyrrolo[2,3-c]pyridin-5-yl-, which are available at competitive prices. Creative Enzymes has established itself as a reliable supplier of chemical products on the echemi.com.
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AZD8931

Product Description

Seller Information

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

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