Lestaurtinib
111358-88-4
98%
Yes
2026-10-25
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName Lestaurtinib Cat No CEI-0484 Description An indolocarbazole derivative with antineoplastic properties. Acts as a potent inhibitor of several tyrosine kinases including FLT3, JAK2, and TrkA with IC50 values of 3, 1, and <25 nM, respectively. It suppresses JAK2/STAT5 signaling and is effective against myeloproliferative disorders in vivo. Alias CEP-701; KT-5555; SPM-924 Appearance White solid Product Overview A PTK inhibitor CAS No 111358-88-4 Molecular Weight 1009.17 Purity >98% Storage -20 centigrade Synonyms CEP-701; KT-5555; SPM-924 Targets FLT3, JAK2, NTRK1 Molecular Formula C26H21N3O4 Solubility DMSO or EtOH Shipping Conditions RT category Antineoplastic Agents(c1417) cas_num 111358-88-4 ECHEMI Editorial ReferenceLestaurtinib is Off-White Solid
LSM-1231 is an indolocarbazole.|Lestaurtinib is an orally bioavailable indolocarbazole derivative with antineoplastic properties. Lestaurtinib inhibits autophosphorylation of FMS-like tyrosine kinase 3 (FLT3), resulting in inhibition of FLT3 activity and induction of apoptosis in tumor cells that overexpress FLT3. (NCI05)Basic Info-
Product Name:
Lestaurtinib
Other Name:9,12-Epoxy-1H-diindolo[1,2,3-fg:3′,2′,1′-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one,2,3,9,10,11,12-hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-,(9S,10S,12R)-;9,12-Epoxy-1H-diindolo[1,2,3-fg:3′,2′,1′-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one,2,3,9,10,11,12-hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-,[9S-(9α,10β,12α)]-;(9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:3′,2′,1′-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one;KT 5555;CEP 701;SP 924;A 154475.0;Lestaurtinib;NSC 621867;156256-78-9
CAS No.:111358-88-4
Molecular Formula:C26H21N3O4
InChIKeys:InChIKey=UIARLYUEJFELEN-LROUJFHJSA-N
Molecular Weight:439.469
Exact Mass:439.46
UNII:DO989GC5D1
DSSTox ID:DTXSID5046778
NCI Thesaurus Code:C48402
Categories:
Characteristics-
PSA:
88.6
XLogP3:3.37
Appearance:Off-white solid
Density:1.70±0.1 g/cm3(Predicted)
Melting Point:215-220°C
Boiling Point:723.0±60.0 °C(Predicted)
Flash Point:391.0±32.9 °C
Refractive Index:1.880
Water Solubility:DMSO: >10mg/mL
Storage Conditions:Desiccate at -20°C
Vapor Pressure:0mmHg at 25°C
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15 days
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
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