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Lestaurtinib

Lestaurtinib structure

CAS No:
111358-88-4
Formula:
C26H21N3O4
Chemical Name:
Lestaurtinib
Synonyms:
9,12-Epoxy-1H-diindolo[1,2,3-fg:3′,2′,1′-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one,2,3,9,10,11,12-hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-,(9S,10S,12R)-;9,12-Epoxy-1H-diindolo[1,2,3-fg:3′,2′,1′-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one,2,3,9,10,11,12-hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-,[9S-(9α,10β,12α)]-;(9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:3′,2′,1′-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one;KT 5555;CEP 701;SP 924;A 154475.0;Lestaurtinib;NSC 621867;156256-78-9
Categories:
Active Pharmaceutical Ingredients > Antineoplastic Agents

Description

Lestaurtinib is Off-White Solid

LSM-1231 is an indolocarbazole.|Lestaurtinib is an orally bioavailable indolocarbazole derivative with antineoplastic properties. Lestaurtinib inhibits autophosphorylation of FMS-like tyrosine kinase 3 (FLT3), resulting in inhibition of FLT3 activity and induction of apoptosis in tumor cells that overexpress FLT3. (NCI05)

Lestaurtinib Basic Attributes

Molecular Weight：

439.469

Exact Mass：

439.46

UNII：

DO989GC5D1

DSSTox ID：

DTXSID5046778

NCI Thesaurus Code：

C48402

Characteristics

PSA：

88.6

XLogP3：

3.37

Appearance：

Off-white solid

Density：

1.70±0.1 g/cm3(Predicted)

Melting Point：

215-220°C

Boiling Point：

723.0±60.0 °C(Predicted)

Flash Point：

391.0±32.9 °C

Refractive Index：

1.880

Water Solubility：

DMSO: >10mg/mL

Storage Conditions：

Desiccate at -20°C

Vapor Pressure：

0mmHg at 25°C

Safety Information

wgk germany：

Stability/Shelf Life：

Photosensitive

Drug Information

Drug Indication：

Investigated for use/treatment in pancreatic cancer, prostate cancer, and leukemia (myeloid).

Mechanism of Action：

Lestaurtinib inhibits autophosphorylation of FMS-like tyrosine kinase 3 (FLT3), resulting in inhibition of FLT3 activity and induction of apoptosis in tumor cells that overexpress FLT3.

MeSH Entry Terms：

CEP 701

Lestaurtinib Use and Manufacturing

Uses

It is used for the treatment of pancreatic cancer and acute myelogenous leukaemia (AML)

Use Classification：

Human drugs -> Rare disease (orphan)

Computed Properties

Molecular Weight:439.5
XLogP3:2.2
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:439.15320616
Monoisotopic Mass:439.15320616
Topological Polar Surface Area:88.6
Heavy Atom Count:33
Complexity:886
Defined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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