Lestaurtinib
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Lestaurtinib
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CAS No:
111358-88-4
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Formula:
C26H21N3O4
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Chemical Name:
Lestaurtinib
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Synonyms:
9,12-Epoxy-1H-diindolo[1,2,3-fg:3′,2′,1′-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one,2,3,9,10,11,12-hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-,(9S,10S,12R)-;9,12-Epoxy-1H-diindolo[1,2,3-fg:3′,2′,1′-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one,2,3,9,10,11,12-hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-,[9S-(9α,10β,12α)]-;(9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:3′,2′,1′-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one;KT 5555;CEP 701;SP 924;A 154475.0;Lestaurtinib;NSC 621867;156256-78-9
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CAS No:
Description
Lestaurtinib is Off-White Solid
LSM-1231 is an indolocarbazole.|Lestaurtinib is an orally bioavailable indolocarbazole derivative with antineoplastic properties. Lestaurtinib inhibits autophosphorylation of FMS-like tyrosine kinase 3 (FLT3), resulting in inhibition of FLT3 activity and induction of apoptosis in tumor cells that overexpress FLT3. (NCI05)
Characteristics
88.6
3.37
Off-white solid
1.70±0.1 g/cm3(Predicted)
215-220°C
723.0±60.0 °C(Predicted)
391.0±32.9 °C
1.880
DMSO: >10mg/mL
Desiccate at -20°C
0mmHg at 25°C
Drug Information
Investigated for use/treatment in pancreatic cancer, prostate cancer, and leukemia (myeloid).
Lestaurtinib inhibits autophosphorylation of FMS-like tyrosine kinase 3 (FLT3), resulting in inhibition of FLT3 activity and induction of apoptosis in tumor cells that overexpress FLT3.
CEP 701
Lestaurtinib Use and Manufacturing
It is used for the treatment of pancreatic cancer and acute myelogenous leukaemia (AML)
Human drugs -> Rare disease (orphan)
Computed Properties
Molecular Weight:439.5
XLogP3:2.2
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:439.15320616
Monoisotopic Mass:439.15320616
Topological Polar Surface Area:88.6
Heavy Atom Count:33
Complexity:886
Defined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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