CEP-32496 hydrochloride
1227678-26-3
0.98%
2026-08-11
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName CEP-32496 hydrochloride Cat No CEI-1274 Description CEP-32496 hydrochloride is a highly potent inhibitor of wild-type BRAF, V600E mutant BRAF and c-Raf with Kd values of 14 nM, 36 nM and 39 nM, respectively. Product Overview CEP-32496 is a selective inhibitor of BRAFV600E with IC50 value of 669 nM. BRAF is a member of Raf kinase family and plays an important role in sending signals (directing cell growth) inside cells. BRAF involves in regulating MAP kinase/ERKs signaling pathway and mutant BRAFV600E activates MAPK pathway, it has been shown that BRAF mutant BRAFV600E is correlated with several human cancers. CEP-32496 is a potent BRAFV600E inhibitor and has a different selectivity with the reported BRAFV600E inhibitor RG7204. Using Ambit Kinomescan Assay, it was shown that CEP-32496 potently binding to RAF family with Kd value ranged from 14 to 39 nmol/L. When tested with a panel of BRAF mutant (A375, SK-MEL-28, Colo-679, HT-144, and Colon-205) cell lines, CEP-32496 showed a selective cytotoxicity profile against tumor cell lines with V600E mutant while had no effect on wild type cell lines (HCT116, Hs578T, LNCaP, DU145, PC-3). CEP-32496 treatment exhibited high cytotoxicity against human tumor cell lines with expression of BRAFV600E while had little effect on wild type BRAF expressed cell lines. In nude mice model with Colo-205 tumor cells subcutaneous xenograft, oral administration of CEP-32496 significantly inhibited pMEK normalization, induced tumor stasis (40%) while control group did not have this phenomenon in a dose of 30 mg/kg. CEP-32496 also inhibits MEK phosphorylation with IC 50 value of 60 nM. CAS No 1227678-26-3 Molecular Weight 553.92 Purity 0.98 Storage Store at -20°C Synonyms CEP 32496 hydrochloride; CEP32496 hydrochloride Targets B-Raf/C-Raf IC50 14 nM (Kd); 36 nM (Kd); 39 nM (Kd) Molecular Formula C24H23ClF3N5O5 Chemical Name 1-[3-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-3-[5-(1,1,1-trifluoro-2-methylpropan-2-yl)-1,2-oxazol-3-yl]urea; hydrochloride Solubility DMSO Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request category Specialty Chemicals(c26) cas_num 1227678-26-3 Basic Info-
Product Name:
CEP-32496
Other Name:CEP-32496;1-(3-(6,7-diMethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-Methylpropan-2-yl)isoxazol-3-yl)urea hydrochloride;CEP 32496 hydrochloride;CEP-32496 (hydrochloride);CEP32496 hydrochloride;N-[3-[(6,7-Dimethoxy-4-quinazolinyl)oxy]phenyl]-N'-[5-(2,2,2-trifluoro-1,1-dimethylethyl)-3-isoxazolyl]urea hydrochloride;CEP-32496 HCl salt;1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxaz
CAS No.:1227678-26-3
Molecular Formula:C24H23ClF3N5O5
InChIKeys:XCZIYUDQUDWQHI-UHFFFAOYSA-N
Molecular Weight:553.9181296
Exact Mass:553.134
UNII:8J0Y5N290S
Categories:
Characteristics-
PSA:
121
XLogP3:6.14870
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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