Gemcitabine HCl
1 Inquiries
122111-03-9
0.98%
2026-08-12
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Inquiry History
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Description
ProductName Gemcitabine HCl Cat No CEI-1347 Description Gemcitabine HCl is an inhibitor of DNA synthesis with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively. Product Overview Gemcitabine HCl is an inhibitor of DNA synthesis with the IC50 value of 240.4±29.0 μM (CCRF-CEM/dCK−/−cells), 14.7±2.8 nM (TC-1 cells), 36.7 ±5.1 μM (TC-1-GR cells), and 50 nM (PANC1 cells). DNA synthesis is the natural or artificial creation of DNA molecules and can be defined as DNA replication, polymerase chain reaction, and gene synthesis. It is reported that DNA synthesis process plays an important role in a variety of cancers, many drugs have been made to target this process to inhibit tumor growth or metastasis. Gemcitabine HCl is a DNA synthesis inhibitor. When tested with pancreatic cancer cell line COLO 357 and L3.6pl, Gemcitabine HCl treatment following genistein which sensitized cells to Gemcitabine HCL significantly inhibited cell growth and increased cell apoptosis. In MIA PaCa-2 cells, Gemcitabine HCl showed markedly cytotoxicity to cells with the IC50 value of 49.7 ±17.7 nM via inhibiting the activity of dDNA. In SCID mice bearing COLO 357 cells orthotopically implanted, compared with control group, treated both genistein and gemcitabine significantly decreased (75%, P <0.01) tumor growth and body weight. CAS No 122111-03-9 Molecular Weight 299.66 Purity 0.98 Storage Store at -20°C Targets PANC1; MIAPaCa2; BxPC3; Capan2 cell lines IC50 50 nM; 40 nM; 18 nM; 12 nM Molecular Formula C9H11F2N3O4.HCI Chemical Name 4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one; hydrochloride Solubility Limited solubility Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request category Antineoplastic Agents(c1417) cas_num 122111-03-9 Basic Info-
Product Name:
Gemcitabine hydrochloride
Other Name:Cytidine,2′-deoxy-2′,2′-difluoro-,hydrochloride (1:1);Cytidine,2′-deoxy-2′,2′-difluoro-,monohydrochloride;LY 188011 hydrochloride;Gemcitabine hydrochloride;Gemzar;Gemsar;Gemcitera;GEMORAL;2′-Deoxy-2′,2′-difluorocytidine monohydrochloride
CAS No.:122111-03-9
Molecular Formula:C9H11F2N3O4.ClH
InChIKeys:InChIKey=OKKDEIYWILRZIA-OSZBKLCCSA-N
Molecular Weight:299.66
Exact Mass:299.048431
EC Number:1308068-626-2
UNII:U347PV74IL
DSSTox ID:DTXSID3047849
NCI Thesaurus Code:C961
HScode:2934999090
Categories:
Characteristics-
PSA:
108
XLogP3:0.09460
Appearance:White crystalline granular, odorless
Melting Point:287-292 °C
Boiling Point:482.7ºC at 760 mmHg
Flash Point:245.7ºC
Water Solubility:H2O: ≥10mg/mL
Storage Conditions:Desiccate at +4°C
Vapor Pressure:2.41E-11mmHg at 25°C
Specific rotation:D +48°; 365 +257.9° (c = 1.0 in deuterated water)
Hazard IdentificationClassification of the substance or mixture
Reproductive toxicity, Category 1B
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H360 May damage fertility or the unborn child
Precautionary statement(s) Prevention P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Inquiry History1 Inquiries
Country Product Purchase Quantity Date Posted 
United Kingdom
Gemcitabine hydrochloride
500 G Dec 1, 2023 Post an enquiry for this product