TAK-700 R-form
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CAS No.:
752243-39-3
Content:
0.98%
Price valid (until):
2026-07-14
Company Type:
Manufactory
Location:
United States
Qualification:
Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName TAK-700 R-form Cat No CEI-1546 Product Overview TAK-700 R-form is a highly selective inhibitor of 17, 20-lyase with IC50 value of 38nM. TAK-700 is a potent and selective inhibitor of the 17, 20-lyase activity of CYP17A1 which is responsible for androgen biosynthesis. Thus, TAK-700 is selected as a candidate for treatment of prostate cancer through reducing the adrenal androgen production. As an inhibitor of CYP17A1, the selectivity of TAK-700 is important to avoid causing the drug-drug interactions or side effects. TAK-700 shows potent inhibitory activity and high selectivity against 17, 20-lyase over other CYPs including 11-hydroxylase and CYP3A4. The IC50 values for 11-hydroxylase and CYP3A4 are above 1μM and above 10μM, respectively. Moreover, in a monkey model, the administration of TAK-700 is found to significantly reduce serum testosterone and DHEA levels. CAS No 752243-39-3 Molecular Weight 307.35 Purity 0.98 Storage Store at-20°C Targets 17, 20-lyase Molecular Formula C18H17N3O2 Chemical Name 6-[(7R)-7-hydroxy-5,6-dihydropyrrolo[1,2-c]imidazol-7-yl]-N-methylnaphthalene-2-carboxamide Solubility Soluble in DMSO Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request category Specialty Chemicals(c26) cas_num 752243-39-3 Basic Info-
Product Name:
Orteronel, (R)-
Other Name:752243-39-3;Orteronel, (R)-;(R)-Orteronel;TAK-700 (R-form);(R)-6-(7-hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl)-N-methyl-2-naphthamide;TAK-700 R-form;UNII-267WB8R4TI;267WB8R4TI;CHEMBL1921985;Orteronel;TAK700;TAK 700
CAS No.:752243-39-3
Molecular Formula:C18H17N3O2
InChIKeys:OZPFIJIOIVJZMN-GOSISDBHSA-N
Molecular Weight:307.3
Exact Mass:307.132076794
UNII:267WB8R4TI
DSSTox ID:DTXSID90226191
Categories:
Characteristics -
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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