High Quality 99% Purity of Azathioprine CAS NO 446-86-6 ISO 9001:2005 REACH Verified Producer
446-86-6
Industrial Grade
99%
Dideu
25kg/Cardboard Drum
Yes
2022-12-31
Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceAzathioprine(Azasan, Imuran; BW 57-322) is a drug that suppresses the immune system and is used in organ transplantation and autoimmune disease. Target: Azathioprine is an immunosuppressive antimetabolite pro-drug. It is an imidazolyl derivative of 6-mercaptopurine and many of its biological effects are similar to those of the parent compound. Azathioprine is converted into 6-mercaptopurine in the body where it blocks purine metabolism and DNA synthesis. Thus it most strongly affects pro
Azathioprine appears as pale yellow crystals or yellowish powder. Decomposes at 243-244°C. Used for the treatment of rheumatoid arthritis. A known carcinogen.|Solid
Azathioprine appears as pale yellow crystals or yellowish powder. Decomposes at 243-244°C. Used for the treatment of rheumatoid arthritis. A known carcinogen.|Azathioprine is a thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS. It has a role as an antineoplastic agent, an antimetabolite, an immunosuppressive agent, a prodrug, a carcinogenic agent, a DNA synthesis inhibitor and a hepatotoxic agent. It is a thiopurine, a C-nitro compound, a member of imidazoles and an aryl sulfide.|Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index. Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. Azathiprine was granted FDA approval on 20 March 1968.|Azathioprine is a Purine Antimetabolite. The mechanism of action of azathioprine is as a Nucleic Acid Synthesis Inhibitor.|Azathioprine is a purine analogue and prodrug of mercaptopurine that is used as an immunosuppressive agent in organ transplantation to prevent rejection and in autoimmune diseases as a corticosteroid sparing agent. Azathioprine is associated with minor, usually transient and asymptomatic elevations in serum aminotransferase levels during therapy and with rare instances of acute, cholestatic liver injury and, with long term use, noncirrhotic portal hypertension as a result of nodular regenerative hyperplasia or sinusoidal obstruction syndrome.|Azathioprine is a purine analogue with cytotoxic and immunosuppressive activity. Azathioprine is a prodrug that is converted by hepatic xanthine oxidase to its active metabolite 6-mercaptopurine (6-MP). 6-MP is further metabolized by hypoxanthine-guanine phosphoribosyltransferase (HGPRT) into 6-thioguanosine-5'-phosphate (6-thio-GMP) and 6-thioinosine monophosphate (6-thio-IMP), both inhibit nucleotide conversions and de novo purine synthesis. This leads to inhibition of DNA, RNA, and protein synthesis. As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes.|An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)Basic Info-
Product Name:
Azathioprine
Other Name:9H-Purine,6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-;Purine,6-[(1-methyl-4-nitroimidazol-5-yl)thio]-;1H-Purine,6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-;6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-9H-purine;NSC 39084;Azathioprine;Azothioprine;Imuran;6-(1-Methyl-4-nitroimidazol-5-yl)thiopurine;6-(1-Methyl-4-nitromidazol-5-ylthio)purine;Muran;BW 57-322;Imurel;Imurek;Azathioprin;Azanin;Azoran;Azamune;Azathropine;Azafor;Azasan;6165-04-4;11120-16-4;33609-91-5
CAS No.:446-86-6
Molecular Formula:C9H7N7O2S
InChIKeys:InChIKey=LMEKQMALGUDUQG-UHFFFAOYSA-N
Molecular Weight:277.27
Exact Mass:277.26
EC Number:207-175-4
UNII:MRK240IY2L
NSC Number:755900|39084
DSSTox ID:DTXSID4020119
NCI Thesaurus Code:C290
Color/Form:Pale yellow crystals from 50% aq acetone
ATC Code:L04AX01|L - Antineoplastic and immunomodulating agents
HScode:2933990090
Categories:
Characteristics-
PSA:
143
XLogP3:0.1
Appearance:Azathioprine appears as pale yellow crystals or yellowish powder. Decomposes at 243-244°C. Used for the treatment of rheumatoid arthritis. A known carcinogen.
Density:1.9±0.1 g/cm3
Melting Point:243.5 °C
Boiling Point:555.8°C at 760 mmHg
Flash Point:368.5±31.5 °C
Refractive Index:1.924
Water Solubility:H2O: <0.1 g/100 mL at 23 ºC;soluble in Dichloromethane and dimethyl sulfoxide.
Storage Conditions:Freezer
Vapor Pressure:7.98E-12mmHg at 25°C
Toxicity:Oral-rat LD50: 535 mg/kg; Oral-Mouse LD50: 1389 mg/kg
Flammability characteristics:It can burn and produce toxic nitrogen and sulfur oxide fumes; side effects of patients after use: changes in liver function, excessive gastrointestinal movement, nausea, vomiting, diarrhea, increased body temperature, low blood pressure, low urine output, no urine
PKA:7.87(at 25 °C)
Dissociation Constants:7.87 (at 25 °C)|pKa = 8.2
Collision Cross Section:155.1 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Experimental Properties:Soly in water: 10 mg/ml /Sodium salt/
Air and Water Reactions:Sensitive to oxidation in the air. Insoluble in water.
Reactive Group:Amines, Phosphines, and Pyridines
Reactivity Profile:AZATHIOPRINE may react exothermically with acids. Incompatible with isocyanates, peroxides, phenols, epoxides, anhydrides, and acid halides. Hydrolyzed by strongly basic solutions (NTP, 1992). May react with strong reducing agents to generate flammable gaseous hydrogen or hydrogen sulfide.
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Oral
Skin irritation, Category 2
Eye irritation, Category 2
Specific target organ toxicity â single exposure, Category 3
Germ cell mutagenicity, Category 1A
Carcinogenicity, Category 1A
Reproductive toxicity, Category 1A
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H302 Harmful if swallowed
H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation
H340 May cause genetic defects
H350 May cause cancer
H360 May damage fertility or the unborn child
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P203 Obtain, read and follow all safety instructions before use.
Response P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P321 Specific treatment (see ... on this label).
P332+P317 If skin irritation occurs: Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P319 Get medical help if you feel unwell.
P318 IF exposed or concerned, get medical advice.
Storage P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Storage of the constituted soln in the original vial and in plastic syringes (Jelco) at 20-25 deg C under fluorescent light resulted in no decomp or precipitation in 16 days. At 4 deg C in the dark, a visible precipitate formed after four days. Azathioprine sodium
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Seller Information
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Business Type:
Manufactory
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Main Products:
Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst
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Location:
https://www.dideu.com/en/
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Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
7 days
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Total Annual Revenue:
Above $100 million
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Total Employees:
Above 1000
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Year of Establishment:
2016
Company Certificates-
ISO Certificate
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REACH
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