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Thioridazine 97% solid

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CAS No.:

50-52-2

Grade:

Pharmaceutical Grade

Content:

97%

Packaging:

25kg/drum

Price valid (until):

2023-01-08

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Shaanxi Dideu Medichem Co. Ltd

Company Type:

Manufactory

Location:

China

Payment Terms:

TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average Lead Time:

7 days

Qualification:

Main Products:

Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst

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Product Description
Seller Information

Description

Product Detail

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Items	Specifications
Appearance	White or of- white powder or crystlline power,odorless
Solubility	Very soluble in N,N-Dimethylformamide,Soluble in methanol,Sparingly soluble inglacial acetic acid, Very slightly soluble inchloroform, Practically insoluble in water.
Melting Point	152°C~156°C

ECHEMI Editorial Reference

Colorless crystals. Soluble in water and alcohol.
Solid
Thioridazine is a phenothiazine derivative having a methylsulfanyl subsitituent at the 2-position and a (1-methylpiperidin-2-yl)ethyl] group at the N-10 position. It has a role as a serotonergic antagonist, a H1-receptor antagonist, an alpha-adrenergic antagonist, a dopaminergic antagonist, a first generation antipsychotic, an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor and an EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor. It is a member of phenothiazines and a member of piperidines. It contains a methylsulfanyl group.|A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p618). Thioridazine was withdrawn worldwide in 2005 due to it's association with cardiac arrythmias.|Thioridazine is a phenothiazine and antipsychotic agent that is no longer in common use. Thioridazine has been linked to rare instances of clinically apparent acute cholestatic liver injury.|A phenothiazine antipsychotic used in the management of PHYCOSES, including SCHIZOPHRENIA.

Basic Info

Product Name:

Thioridazine

Other Name:

10H-Phenothiazine,10-[2-(1-methyl-2-piperidinyl)ethyl]-2-(methylthio)-;Phenothiazine,10-[2-(1-methyl-2-piperidyl)ethyl]-2-(methylthio)-;10-[2-(1-Methyl-2-piperidinyl)ethyl]-2-(methylthio)-10H-phenothiazine;TP 21;Mellerette;Melleril;2-Methylmercapto-10-[2-N-methyl-2-piperidyl)ethyl]phenothiazine;10-[2-(1-Methyl-2-piperidyl)ethyl]-2-(methylthio)phenothiazine;Thioridazin;Thioridazine;Thioridazine prolongatum;Malloryl;Meleril;Mellerets;Sonapax;Melleril (liquid);dl-Thioridazine;(±)-Thioridazine;Mellaril S;10-[2-(1-Methylpiperidin-2-yl)ethyl]-2-methylsulfanylphenothiazine;10-[2-(1-Methylpiperidin-2-yl)ethyl]-2-(methylsulfanyl)-10H-phenothiazine;57129-06-3

CAS No.:

50-52-2

Molecular Formula:

C21H26N2S2

InChIKeys:

InChIKey=KLBQZWRITKRQQV-UHFFFAOYSA-N

Molecular Weight:

370.57

Exact Mass:

370.57

EC Number:

200-044-2

DSSTox ID:

DTXSID6023656

Color/Form:

Crystals from acetone|Colorless crystals

ATC Code:

N - Nervous system

HScode:

2934302300

Categories:

Nervous System Drugs

Characteristics

PSA:

57.1

XLogP3:

5.9

Appearance:

Solid

Density:

1.2±0.1 g/cm3

Melting Point:

72-74 °C

Boiling Point:

230 °C @ Press: 0.02 Torr

Flash Point:

9℃

Refractive Index:

1.677

Water Solubility:

1.113mg/L(22.5 ºC)

Storage Conditions:

-20°C

Vapor Pressure:

3.69X10-8 mm Hg at 25 deg C (est)

Toxicity:

LD50 orally in rats: 995 ±39 mg/kg (Goldenthal)

Odor:

Faint

Taste:

Very bitter

PKA:

9.5None

Henrys Law Constant:

Henry's Law constant = 1.50X10-11 atm-cu m/mol at 25 °C (est)

Dissociation Constants:

9.5|pKa = 9.5

Collision Cross Section:

184.9 Å² [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)]

Experimental Properties:

White to slightly yellow, granular powder; freely soluble in chloroform; slightly soluble in benzene /Thioridazine hydrochloride/

See More Thioridazine Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Oral

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H302 Harmful if swallowed H400 Very toxic to aquatic life H410 Very toxic to aquatic life with long lasting effects
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P273 Avoid release to the environment.
Response	P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P391 Collect spillage.
Storage	none
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Thioridazine Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst

Location:
https://www.dideu.com/en/

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
7 days

Total Annual Revenue:
Above $100 million

Total Employees:
Above 1000

Year of Establishment:
2016

Company Certificates
- ISO Certificate
- REACH
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Thioridazine 97% solid

Product Description

Seller Information

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

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