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Plinabulin(NPI-2358) 99%

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CAS No.:

714272-27-2

Grade:

Reagent Grade

Content:

99%

Packaging:

custom

Price valid (until):

2023-04-07

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Maydy Biotechnology Co., Ltd

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Plinabulin,Bromfenac sodium,Acotiamide,BI6727

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Product Description
Seller Information

Description

Product Detail

SECTION 1: Identification

1.1GHS Product identifier

Product name	(3Z,6Z)-3-benzylidene-6-[(5-tert-butyl-1H-imidazol-4-yl)methylidene]piperazine-2,5-dione

1.2Other means of identification

Product number	-
Other names	3-(Z)-benzylidene-6-(((Z)-5-tert-butyl-1H-imidazol-4-yl)methylene)-piperazine-2,5-dione;Plinabulin,NPI2358,NPI-2358;3-Z-benzylidene-6-(5"-tert-butyl-1H-imidazol-4"-Z-ylmethylene)-piperazine-2,5-dione

1.3Recommended use of the chemical and restrictions on use

Identified uses	Industrial and scientific research use.
Uses advised against	no data available

1.4Supplier's details

Company	Maydy Biotechnology Co., Ltd.
Address	No.118, No.119, No.120, Area A, Headquarters Economic Industrial Park, Higher Vocational Park, No. 12 Chengxin Road, Gaochun District, Nanjing, Jiangsu Province, China
Mobile	86-18251822644

1.5Emergency phone number

Emergency phone number	86-19941775929
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

SECTION 2: Hazard identification

2.1Classification of the substance or mixture

no data available

2.2GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

2.3Other hazards which do not result in classification

no data available

SECTION 3: Composition/information on ingredients

3.1Substances

Chemical name	Common names and synonyms	CAS number	EC number	Concentration
(3Z,6Z)-3-benzylidene-6-[(5-tert-butyl-1H-imidazol-4-yl)methylidene]piperazine-2,5-dione	(3Z,6Z)-3-benzylidene-6-[(5-tert-butyl-1H-imidazol-4-yl)methylidene]piperazine-2,5-dione	714272-27-2	-	100%

SECTION 4: First-aid measures

4.1Description of necessary first-aid measures

If inhaled

Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.

Following skin contact

Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.

Following eye contact

Rinse with pure water for at least 15 minutes. Consult a doctor.

Following ingestion

Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.

4.2Most important symptoms/effects, acute and delayed

no data available

4.3Indication of immediate medical attention and special treatment needed, if necessary

no data available

SECTION 5: Fire-fighting measures

5.1Suitable extinguishing media

Use dry chemical, carbon dioxide or alcohol-resistant foam.

5.2Specific hazards arising from the chemical

no data available

5.3Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

SECTION 6: Accidental release measures

6.1Personal precautions, protective equipment and emergency procedures

Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak.

6.2Environmental precautions

Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided.

6.3Methods and materials for containment and cleaning up

Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.

SECTION 7: Handling and storage

7.1Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

7.2Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

SECTION 8: Exposure controls/personal protection

8.1Control parameters

Occupational Exposure limit values

no data available

Biological limit values

no data available

8.2Appropriate engineering controls

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

8.3Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Wear tightly fitting safety goggles with side-shields conforming to EN 166(EU) or NIOSH (US).

Skin protection

Wear fire/flame resistant and impervious clothing. Handle with gloves. Gloves must be inspected prior to use. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

If the exposure limits are exceeded, irritation or other symptoms are experienced, use a full-face respirator.

Thermal hazards

no data available

SECTION 9: Physical and chemical properties and safety characteristics

Physical state	no data available
Colour	no data available
Odour	no data available
Melting point/freezing point	no data available
Boiling point or initial boiling point and boiling range	730.345°C at 760 mmHg
Flammability	no data available
Lower and upper explosion limit/flammability limit	no data available
Flash point	395.498°C
Auto-ignition temperature	no data available
Decomposition temperature	no data available
pH	no data available
Kinematic viscosity	no data available
Solubility	no data available
Partition coefficient n-octanol/water	no data available
Vapour pressure	no data available
Density and/or relative density	1.267
Relative vapour density	no data available
Particle characteristics	no data available

SECTION 10: Stability and reactivity

10.1Reactivity

no data available

10.2Chemical stability

no data available

10.3Possibility of hazardous reactions

no data available

10.4Conditions to avoid

no data available

10.5Incompatible materials

no data available

10.6Hazardous decomposition products

no data available

SECTION 11: Toxicological information

Acute toxicity

Oral: no data available
Inhalation: no data available
Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

no data available

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

SECTION 12: Ecological information

12.1Toxicity

Toxicity to fish: no data available
Toxicity to daphnia and other aquatic invertebrates: no data available
Toxicity to algae: no data available
Toxicity to microorganisms: no data available

12.2Persistence and degradability

no data available

12.3Bioaccumulative potential

no data available

12.4Mobility in soil

no data available

12.5Other adverse effects

no data available

SECTION 13: Disposal considerations

13.1Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

SECTION 14: Transport information

14.1UN Number

ADR/RID: no data available

IMDG: no data available

IATA: no data available

14.2UN Proper Shipping Name

ADR/RID: no data available

IMDG: no data available

IATA: no data available

14.3Transport hazard class(es)

ADR/RID: no data available

IMDG: no data available

IATA: no data available

14.4Packing group, if applicable

ADR/RID: no data available

IMDG: no data available

IATA: no data available

14.5Environmental hazards

ADR/RID: No

IMDG: No

IATA: No

14.6Special precautions for user

no data available

14.7Transport in bulk according to IMO instruments

no data available

SECTION 15: Regulatory information

15.1Safety, health and environmental regulations specific for the product in question

Chemical name	Common names and synonyms	CAS number	EC number
(3Z,6Z)-3-benzylidene-6-[(5-tert-butyl-1H-imidazol-4-yl)methylidene]piperazine-2,5-dione	(3Z,6Z)-3-benzylidene-6-[(5-tert-butyl-1H-imidazol-4-yl)methylidene]piperazine-2,5-dione	714272-27-2	-
European Inventory of Existing Commercial Chemical Substances (EINECS)			Not Listed.
EC Inventory			Not Listed.
United States Toxic Substances Control Act (TSCA) Inventory			Not Listed.
China Catalog of Hazardous chemicals 2015			Not Listed.
New Zealand Inventory of Chemicals (NZIoC)			Not Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS)			Not Listed.
Vietnam National Chemical Inventory			Not Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC)			Not Listed.
Korea Existing Chemicals List (KECL)			Not Listed.

SECTION 16: Other information

Information on revision

Creation Date	July 15, 2019
Revision Date	July 15, 2019

Abbreviations and acronyms

CAS: Chemical Abstracts Service
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
IMDG: International Maritime Dangerous Goods
IATA: International Air Transportation Association
TWA: Time Weighted Average
STEL: Short term exposure limit
LC50: Lethal Concentration 50%
LD50: Lethal Dose 50%
EC50: Effective Concentration 50%

References

IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Items	Specifications
Appearance	White or of- white powder or crystlline power,odorless
Solubility	Very soluble in N,N-Dimethylformamide,Soluble in methanol,Sparingly soluble inglacial acetic acid, Very slightly soluble inchloroform, Practically insoluble in water.
Melting Point	152°C~156°C

Basic Info

Product Name:

Plinabulin

Other Name:

2,5-Piperazinedione,3-[[5-(1,1-dimethylethyl)-1H-imidazol-4-yl]methylene]-6-(phenylmethylene)-,(3Z,6Z)-;(3Z,6Z)-3-[[5-(1,1-Dimethylethyl)-1H-imidazol-4-yl]methylene]-6-(phenylmethylene)-2,5-piperazinedione;NPI 2358;Plinabulin;BPI 2358

CAS No.:

714272-27-2

Molecular Formula:

C19H20N4O2

InChIKeys:

InChIKey=UNRCMCRRFYFGFX-TYPNBTCFSA-N

Molecular Weight:

336.4

Exact Mass:

336.39

EC Number:

-0

Categories:

Antineoplastics

Characteristics

PSA:

94.92000

XLogP3:

2.66

Density:

1.3±0.1 g/cm3

Boiling Point:

730.3±60.0 °C at 760 mmHg

Flash Point:

395.5±32.9 °C

Refractive Index:

1.657

See More Plinabulin Properties 

Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Plinabulin Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Plinabulin,Bromfenac sodium,Acotiamide,BI6727

Location:
No. 118, No. 119, No. 120, Area A, Headquarters Economic Industrial Park, Higher Vocational Park, No. 12 Chengxin Road, Gaochun District, Nanjing, Jiangsu Province, China.

Payment Terms:
L/C,100% TT in advance

Average lead Time:
30

Total Annual Revenue:
$1 million-$2.5 million

Total Employees:
5-10

Year of Establishment:
2023

Maydy Biotechnology Co., Ltd. is a high-tech service enterprise based on the synthesis of biopharmaceuticals and chemical drugs. The company is committed to the technological research and production of biopharmaceuticals and chemical drugs. Based on the global pharmaceutical market demand, it integrates the process development, pilot-scale production, commercial production and innovative drug research and development of key intermediates. Technical backbone members of the team have domestic and foreign large-scale pharmaceutical production, management experience.
At present, the company has a R & D laboratory of 2000 square meters in Life & Science Industry Park ,Jiangning Dist, and equipped with a full set of pilot and pilot equipment, complete good testing and analysis platform, we will be the most cost-effective price for global customers to provide the best quality services.
Country Product Purchase Quantity Date Posted

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Plinabulin(NPI-2358) 99%

Product Description

Seller Information

SECTION 1: Identification

1.1GHS Product identifier

1.2Other means of identification

1.3Recommended use of the chemical and restrictions on use

1.4Supplier's details

1.5Emergency phone number

SECTION 2: Hazard identification

2.1Classification of the substance or mixture

2.2GHS label elements, including precautionary statements

2.3Other hazards which do not result in classification

SECTION 3: Composition/information on ingredients

3.1Substances

SECTION 4: First-aid measures

4.1Description of necessary first-aid measures

If inhaled

Following skin contact

Following eye contact

Following ingestion

4.2Most important symptoms/effects, acute and delayed

4.3Indication of immediate medical attention and special treatment needed, if necessary

SECTION 5: Fire-fighting measures

5.1Suitable extinguishing media

5.2Specific hazards arising from the chemical

5.3Special protective actions for fire-fighters

SECTION 6: Accidental release measures

6.1Personal precautions, protective equipment and emergency procedures

6.2Environmental precautions

6.3Methods and materials for containment and cleaning up

SECTION 7: Handling and storage

7.1Precautions for safe handling

7.2Conditions for safe storage, including any incompatibilities

SECTION 8: Exposure controls/personal protection

8.1Control parameters

Occupational Exposure limit values

Biological limit values

8.2Appropriate engineering controls

8.3Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Skin protection

Respiratory protection

Thermal hazards

SECTION 9: Physical and chemical properties and safety characteristics

SECTION 10: Stability and reactivity

10.1Reactivity

10.2Chemical stability

10.3Possibility of hazardous reactions

10.4Conditions to avoid

10.5Incompatible materials

10.6Hazardous decomposition products

SECTION 11: Toxicological information

Acute toxicity

Skin corrosion/irritation

Serious eye damage/irritation

Respiratory or skin sensitization

Germ cell mutagenicity

Carcinogenicity

Reproductive toxicity

STOT-single exposure

STOT-repeated exposure

Aspiration hazard

SECTION 12: Ecological information

12.1Toxicity

12.2Persistence and degradability

12.3Bioaccumulative potential

12.4Mobility in soil

12.5Other adverse effects

SECTION 13: Disposal considerations

13.1Disposal methods

Product

Contaminated packaging

SECTION 14: Transport information

14.1UN Number

14.2UN Proper Shipping Name

14.3Transport hazard class(es)

14.4Packing group, if applicable

14.5Environmental hazards

14.6Special precautions for user