Trichloroethylene CAS NO.79-01-6 Trichloroethylene, Stabilized Factory Supply liquid

Trichloroethylene

Trichloroethylene, Stabilized, SpectroSolv (TM);Trichloroethylene, stabilized with 400 ppM triethylaMine;Trichloroethylene, SuperDry, stabilized, J&KSeal;TRICHLOROETHYLENE FOR ANALYSIS EMSURE;TRICHLOROETHYLENE EMPLURA 1 L;TRICHLOROETHYLENE EMPLURA 190 L;TRICHLOROETHYLENE EMPLURA 25 L;Trichloroethylene, Stabilized

79-01-6

C2HCl3

XSTXAVWGXDQKEL-UHFFFAOYSA-N

131.39

131.39

1736782

201-167-4

TSCA listed

Clear colorless

29032200

Anesthetic Agents

0

Clear, colorless, watery-liquid with a chloroform-like odor. Odor threshold concentrations determined in air were 21.4 ppmv(Leonardos et al., 1969) and 3.9 ppmv(Nagata and Takeuchi, 1990). The average least detectable odor threshold concentrations in water at 60 °C and in air at 40 °C were 10 and 2.6 mg/L, respectively (Alexander et al., 1982).

Reactivity with Water No reaction; Reactivity with Common Materials: No reaction; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

2.5017

Colorless transparent liquid, with the same odor as a chloroform

1.463 g/mL at 25 °C(lit.)

-86 °C

87 °C

90°C

n20/D1.476(lit.)

Slightly soluble. 0.11 g/100 mL

Storage Room low temperature ventilation drying ,Separate storage with food additives

61 mm Hg ( 20 °C)

4.5 (vs air)

Extended exposure (e.g., occupational exposure) to a chlorinated solvent like TCE typically results in signs of central nervous system (CNS) disturbance and hepatotoxicity. The primary target tissues for the carcinogenicity of TCE identified in animal studies are the liver, lung, and kidney. For each of these target tissues there is evidence that the carcinogenicity of TCE may be associated with one or more of its metabolites: TCA and dichloroacetic acid (DCA) in the liver, chloral in the lung, and S-(1,2-dichlorovinyl)-L-cysteine (DCVC) in the kidney.TCA acts as a peroxisome proliferator, and hepatic neoplasms in mice may arise through this mechanism. TCE metabolism via cytochrome P450 generates the metabolites DCA and TCA, which are associated with hepatotoxicity and liver cancer. DCA and TCA may induce hepatic tumorigenesis by (1) modification of signaling pathways; (2) cytotoxicity, cell death, and reparative hyperplasia; and (3) direct DNA damage.TCE metabolism via glutathione (GSH) conjugation generates DCVC, which is associated with nephrotoxicity and kidney cancer. DCVC can be both bioactivated and detoxified by different enzymes. The enzyme that is primarily responsible for renal bioactivation of nephrotoxic cysteine S-conjugates is the b-lyase. The reactive thiol and subsequent species generated from b-lyase-catalyzed metabolism of DCVC may induce renal tumorigenesis by (1) peroxisome proliferation, (2) a-2uglobulin nephropathy, (3) genotoxicity leading to somatic mutation, and (4) acute cytotoxicity and necrosis leading to cell proliferation.

Non flammable

vol% in air: 7.9 100

Chloroform-like; ethereal.

Sweet burning taste

3.14 at 1.8 °C, 8.47 at 21.6 °C, 19.0 at 40.0 °C, 26.5 at 50 °C, 35.8 at 60 °C, 56.6 at 70 °C (EPICS-GC, Shimotori and Arnold, 2003)

Slightly soluble in water.

Trichloroethylene has been determined experimentally that mixtures of finely divided barium metal and a number of halogenated hydrocarbons possess an explosive capability. Specifically, impact sensitivity tests have shown that granular barium in contact with monofluorotrichloromethane, trichlorotrifluoroethane, carbon tetrachloride, Trichloroethylene, or tetrachloroethylene can detonate (ASESB Pot. Incid. 39. 1968; Chem. Eng. News 46(9):38. 1968). Trichloroethylene has been determined experimentally that a mixture of beryllium powder with carbon tetrachloride or with Trichloroethylene will flash or spark on heavy impact (ASESB Pot. Incid. 39. 1968). A mixture of powdered magnesium with Trichloroethylene or with carbon tetrachloride will flash or spark under heavy impact (ASESB Pot. Incid, 39. 1968).

770°F

2-8°C