Plant Extract anti-osteoporosis natural estrogen effect with genistein 98%

Manufacturer supply Sophora japonica extract. 98% genistein CAS NO.446-72-0

Product name : genistein

Botanical source: Sophora japonica L.

Specification : 98%

Appearance : White Fine powder

CAS NO. 446-72-0

Molecular weight : 270.24

Extract solvent : Ethanol

Heavy metals: <1ppm

GMO: Non-GMO

Irradiation: Non-Irradiation

Test method : HPLC

Application : Food supplements. Healthcare supplements

Standard : USP/EP Standard

MOQ: 50grams, 100grams, 1kg 

Sample Policy : Free sample can be provided for checking .

Brief introduction of Genistein                                                                                          

Genistein Mainly exists in leguminosae, such as Huaijiao(Sophora japonica L.), greater content of roots and roots

An isoflavonoid derived from soy products. Shaanxi Creative Herb Biotechnology Co,.LTD can supply Genistein 98% from Sophora japonica L.

1 Genistein inhibits protein tyrosine kinases, including the EGF receptor kinase (IC50 = 2.6 µM). The inhibition is competitive with respect to ATP and non-competitive with respect to the phosphate acceptor.1,2 It has a trivial effect on the activity of PKA and PKC (IC50 > 350 µM).1,2 In addition, Genistein inhibits Topoisomerase II activity,3 cause cell cycle arrest and apoptosis in Jurkat T-leukemia cells.4 It down regulates the transcription of genes involved in angiogenesis,5,6 and inhibit the action of GABA on recombinant GABA-A receptors.7 Genistein also inhibits tumor cell proliferation and induces tumor cell differentiation. 8-10

How does genistein produce good effect to women ?                                                            1. genistein with Anti-Osteoporsis

Italian researchers including Francesco Squadrito, MD, of Italy's University of Messina.

They studied 389 postmenopausal Italian women with osteopenia, in which bone mineral density is less than ideal but not as severe as osteoporosis

2.Genistein With anti-oxidation, with estrogen and anti-estrogen properties

GEN (genistein or genistein) and its aglycone are the highest content of soybean isoflavones,

The aglycone form of soybean isoflavone is more active than the glycoside form, especially the Genistein activity is more higher.With phytoestrogen bidirectional regulation. MCF-7 cells are ER positive human breast cancer cell lines, it Can specifically accept estrogen 

or estrogen-like active substances to regulate and proliferate .Estrogen-like value-added is very sensitive, simple, it can distinguish between agonists and antagonists, So it is widely

used in the rapid screening and evaluation of phytoestrogens of environmental estrogens.

3. 2.Genistein with Anti-bacteria

The antibacterial mechanism is through the destruction of cell wall and cell membrane integrity, inhibition of TCA cycle pathway and protein synthesis and so on. This is consistent with Kim's view on the antibacterial mechanism of drugs [11]. As genistein has antibacterial and antioxidant activity and other physiological aspects, from the nutritional point of view, if you use Gen as a food additive to play its dual role, the application of a very broad prospect.

Application : Food supplements. Healthcare supplements. Widely used for women healthcare supplements