Pyrimethamine Manufacturer/High quality/Best price/In stock
58-14-0
98%
according to the clients requirement
Yes
2024-12-31
N-Diethyl-m-toluamide,6-Methyluracil,Anisole,4-Dimethoxybenzoic acid,CS (lacrimator),Daucosterol
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Product Description
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Seller Information
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DescriptionKeywords
Hot sale Pyrimethamine
Supply Pyrimethamine
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Quick DetailsProName:Pyrimethamine Manufacturer/High quality/Best price/In stock
CasNo:58-14-0
Molecular Formula:C12H13ClN4
Appearance:detailed see specifications
Application:It is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and Dyestuff.
DeliveryTime:prompt
PackAge:according to the clients requirement
Port:Shanghai
ProductionCapacity:1-100 Metric Ton/Month
Purity:98%
Storage:Store in dry, dark and ventilated place.
Transportation:by sea or by air
LimitNum:1 Kilogram
SuperiorityDayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice.
Pls contact with us freely for getting detailed product specifications, product tech. date sheet, COA and MSDS, prices, delivery time and payment terms.
As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis chemicals in lab, plant and industrial scale with more than fifteen years.
Details
Dayang Chem (Hangzhou) Co.Limited, established in 2000, dedicated to the development, production and marketing of chemicals. We are a leading manufacturer and supplier of chemicals in China.
Manufacturing base: The Company has some Manufacturing base in Zhejiang, Jiangsu and Shandong provide. These bases focus on production and Contract Manufacturing.
Sales agent: Dayangchem are authorized by many Chinese chemical manufacturers as universal agency and international area agency. Dayangchem has established very good cooperation and business relations with hundreds of Chinese qualified manufacturers by long time business intercourse.
Strong quality control system: Strength of our ethical commitment to quality control and quality assurance systems firmly based on ISO standard. QA and QC used in the whole process of raw material control, process control and finished product quality inspection.
Flexible payment terms: Various payment terms such as L/C,D/P,D/A and T/T will be accepted. Special Notice: DAYANGCHEM never require customers to remit payment to a personal account. Beware of being cheated.
Rich experience in sales: 1000 square meters of office space with independent property rights, Sales team of nearly 40 people. Our customers throughout the world, especially the world-renowned companies, such as BACHEM, BASF, CELANESE, CORDEN,DOW,EVONIK, GENZYME,HENKEL, MERCK,ROCHE,SANOFI,SOLVAY.
ECHEMI Editorial ReferencePyrimethamine(RP4753) is a medication used for protozoal infections; interferes with tetrahydrofolic acid synthesis from folic acid by inhibiting the enzyme dihydrofolate reductase (DHFR).IC50 Value: 15.4 nM (Plasmodium falciparum) [1]Target: DHFR; antifolatein vitro: Three susceptibility levels (susceptible, intermediate, and resistant) were observed in the response of culture-adapted clones and strains to pyrimethamine (50% inhibitory concentration [IC50]) < 100, 100-2,000, and > 2,000
Pyrimethamine is an odorless white crystalline powder. Tasteless. An antimalarial drug.|Solid
Pyrimethamine is an odorless white crystalline powder. Tasteless. An antimalarial drug.|Pyrimethamine is an aminopyrimidine that is pyrimidine-2,4-diamine which is substituted at position 5 by a p-chlorophenyl group and at position 6 by an ethyl group. It is a folic acid antagonist used as an antimalarial or with a sulfonamide to treat toxoplasmosis. It has a role as an antimalarial, an EC 1.5.1.3 (dihydrofolate reductase) inhibitor and an antiprotozoal drug. It is an aminopyrimidine and a member of monochlorobenzenes.|One of the folic acid antagonists that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis.|Pyrimethamine is a Dihydrofolate Reductase Inhibitor Antimalarial. The mechanism of action of pyrimethamine is as a Dihydrofolate Reductase Inhibitor.|Pyrimethamine is a synthetic derivative of ethyl-pyrimidine with potent antimalarial properties. Pyrimethamine is a competitive inhibitor of dihydrofolate reductase (DHFR). DHFR is a key enzyme in the redox cycle for production of tetrahydrofolate, a cofactor that is required for the synthesis of DNA and proteins. This agent is often used in combination with other antimalarials for the treatment of uncomplicated falciparum malaria. (NCI04)|One of the FOLIC ACID ANTAGONISTS that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis.Basic Info-
Product Name:
Pyrimethamine
Other Name:2,4-Pyrimidinediamine,5-(4-chlorophenyl)-6-ethyl-;Pyrimidine,2,4-diamino-5-(p-chlorophenyl)-6-ethyl-;5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine;4753 R.P.;BW 50-63;Chloridin;Chloridine;Darapram;Daraprim;2,4-Diamino-5-p-chlorophenyl-6-ethylpyrimidine;Malocide;Pyrimethamine;Daraprime;5-(4-Chlorophenyl)-2,4-diamino-6-ethylpyrimidine;2,4-Diamino-5-(4-chlorophenyl)-6-ethylpyrimidine;5-(P-Chlorophenyl)-6-ethyl-2,4-diaminopyrimidine;Darachlor;Malocid;Pirimetamin;Tindurin;Khloridin;Malacid;Pyrimethamin;Pirimecidan;Diaminopyritamin;Erbaprelina;NSC 3061;WR 2978;RP 4753;Tinduring
CAS No.:58-14-0
Molecular Formula:C12H13ClN4
InChIKeys:InChIKey=WKSAUQYGYAYLPV-UHFFFAOYSA-N
Molecular Weight:248.71
Exact Mass:248.71
EC Number:200-364-2
UNII:Z3614QOX8W
NSC Number:757306|3061
UN Number:2811
DSSTox ID:DTXSID9021217
NCI Thesaurus Code:C788
Color/Form:Crystals|White scored tablets contains 25 mg pyrimethamine /Daraprim/
ATC Code:P01BD01|P - Antiparasitic products, insecticides and repellents
HScode:2933599090
Categories:
Characteristics-
PSA:
77.8
XLogP3:2.7
Appearance:Pyrimethamine is an odorless white crystalline powder. Tasteless. An antimalarial drug.
Density:1.4±0.1 g/cm3
Melting Point:233.5 °C
Boiling Point:491.5°C at 760 mmHg
Flash Point:176.6±30.7 °C
Refractive Index:1.667
Water Solubility:H2O: <0.01 g/100 mL at 21 ºC
Storage Conditions:0-6°C
Vapor Pressure:1.32X10-8 mm Hg at 25 deg C (est)
Toxicity:LD50 oral in rat: 440mg/kg
PKA:7.34(at 20 °C)
Henrys Law Constant:Henry's Law constant = 1.08X10-10 atm-cu m/mol at 25 °C (est)
Dissociation Constants:7.34 (at 20 °C)|pKa = 7.34 at 20 °C (conjugate acid)
Collision Cross Section:155.8 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Experimental Properties:Hydroxyl radical reaction rate constant = 2.0X10-10 cu cm/molecule-sec at 25 °C (est)
Air and Water Reactions:Insoluble in water.
Reactive Group:Amines, Phosphines, and Pyridines
Reactivity Profile:PYRIMETHAMINE is sensitive to exposure to light (NTP, 1992). Neutralizes acids to form salts plus water in exothermic reactions. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Oral
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H302 Harmful if swallowed
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
Response P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
Storage none
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store at 15 deg to 25 deg C (59 deg to 77 deg F) in a dry place and protect from light.
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Seller Information
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Business Type:
Manufactory
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Main Products:
N-Diethyl-m-toluamide,6-Methyluracil,Anisole,4-Dimethoxybenzoic acid,CS (lacrimator),Daucosterol
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Location:
RM901-7,Unit 2,259# WenSan Road, Xihu District, Hangzhou Zhejiang, China
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Payment Terms:
TT against copy of documents,D/P,L/C,D/A,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
2 days
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Total Annual Revenue:
$10 million-$25 million
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Total Employees:
11-50
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Year of Establishment:
2020
Company Certificates-
Dangerous Chemicals Business License
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Pesticide Business License
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ISO 9001:2015
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
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