Factory Supply High Quality Hydroxypropyl Methyl Cellulose (HPMC) 99% Solid CAS 9004-65-3

Bioactivity of hydroxypropyl methyl cellulose
Description Hypromellose is a water-soluble hydrophilic nonionic cellulose ether used to form a swelling soluble matrix.
Related category
Signal Path >> Other >> Other
Field of Study >> Other
In vitro studies, hydroxypropyl methylcellulose releases drugs in a controlled manner, effectively prolonging the duration of drug release and thus prolonging its therapeutic effect [1]. Hydroxypropyl methylcellulose (hydroxypropyl methylcellulose) has been used in sustained-release pharmaceutical products for many years. When used in matrix tablets, these polymers hydrate when in contact with water, creating a viscous gel barrier in and around the tablet. Properties that affect the rate of drug release include the rate of water diffusion into the dry polymer, the rate of hydration and gel formation of HCG, the viscosity of HCG hydrate, and the rate of HCG gel erosion [2].
In vivo studies of lacrimal occlusion using 2% hydroxypropyl methylcellulose are a low-cost and safe additional treatment for dry eye. Fluorescein and rose red staining tests showed a significant reduction in physical signs after treatment with hydroxypropyl methylcellulose [3]. Hydroxypropyl methancellulose effectively improved blood glucose metabolism and inhibited oxidative stress in mice fed a high-fat diet. The anti-hyperglycemic and antioxidant effects of hydroxypropyl methylcellulose can be partially attributed to the regulation of hepatic glucose-regulating enzyme activity and the activation of antioxidant enzymes in liver and red blood cells. Hydroxypropyl methylcellulose can be used as a biomaterial in the development of functional foods or as a therapeutic agent against high-fat induced hyperglycemia and oxidative stress [4].
reference
[1]. Li CL, et al. The use of hypromellose in oral drug delivery. J Pharm Pharmacol. 2005 May; 57 (5) : 533-46.

[2]. Braund R, et al. Hypromellose films for the delivery of growth factors for wound healing.

[3]. Capita L, et al. Prospective evaluation of hypromellose 2% for punctal occlusion in patients with dry eye. Cornea. 2015 Feb; 34 (2) : 188-92.

[4]. Ban SJ, et al. Antihyperglycemic and antioxidative effects of Hydroxyethyl Methylcellulose (HEMC) and Hydroxypropyl Methylcellulose (HPMC) in mice fed with a high fat diet. Int J Mol Sci. 2012; 13 (3) : 3738-50.

Physical and chemical properties of hydroxypropyl methyl cellulose
Density 1.39
Molecular formula C18H38O14
Molecular weight 478.49
Appearance character powder
Storage condition
1. Lined with plastic bags and packed with multi-layer kraft paper, moisture-proof, moisture-proof, store in a cool and dry place. Keep away from fire and heat.

stability
1. Unstable at normal temperature and pressure

2. Avoid wet, open flame, high temperature. Non-ionic ethers, which do not interact with heavy metals, are not affected by acids and bases in the pH range of 2 to 12. It has good film forming properties.
Water solubility H2O: 50 mg/mL, clear to very faintly turbid, faintly yellow | SOLUBLE
Computational chemistry
1. Reference value for calculating hydrophobic parameters (XlogP) : None

2. Number of hydrogen bond donors :8

3. Number of hydrogen bond receptors :30

4. Number of rotatable chemical bonds :40

5. Number of tautomers: None

6. Topological molecular polar surface area 365

7. Number of heavy atoms :86

8. Surface charge :0

9. Complexity :1480

10. Number of isotope atoms :0

11. Determine the number of atomic stereocenter :20

12. Number of uncertain atomic stereocentes :8

13. Determine the number of chemical bond structure centers :0

14. Number of uncertain chemical bond stereocenter :0

15. Number of covalent bond units :2

more
1. Properties: white fibrous or granular powder. Odorless, odorless.

2. Density (g/mL,25/4℃) : 1.39

3. Relative vapor density (g/mL, air =1) : not determined

4. Melting point (ºC) : not determined

5. Boiling point (ºC, atmospheric pressure) : not determined

6. Boiling point (ºC,5.2kPa) : not determined

7. Refractive index: not determined

8. Flash point (ºC) : Undetermined

9. Specific rotation (º) : not determined

10. Spontaneous ignition point or ignition temperature (ºC) : not determined

11. Vapor pressure (kPa,25ºC) : not determined

12. Saturated vapor pressure (kPa,60ºC) : not determined

13. Heat of combustion (KJ/mol) : not determined

14. Critical temperature (ºC) : not determined

15. Critical pressure (KPa) : not determined

16. Value of oil-water (octanol/water) distribution coefficient: not determined

17. Upper explosion limit (%,V/V) : not determined

18. Lower explosive limit (%,V/V) : not determined

19. Solubility: solubility in water is 50mg/mL and some organic solvents, insoluble in anhydrous ethanol, aldehydes and chloroform. 20. Gel temperature (0.2%) : 60 ~ 67℃ 21. Viscosity (2%, 20℃) : 40 ~ 60 mpa ·s