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What is Phloretin ?

Phloretin,belongs to the flavonoids, which are mainly found in apple branches and leaves, apple fruits/peel, apple tree roots/peel, lychee pericarp,It has been found to have antioxidant, anti-tumour, anti-inflammatory, immunosuppressive, bone formation and other pharmacological effects.

It has been found that Phloretin has a variety of pharmacological effects such as antioxidant, anti-tumour, anti-inflammatory, immunosuppressive, promoting bone formation, etc., in addition to whitening, acne and other effects. Phloretin can be directly absorbed by the human body, but in the plant body, the natural existence of Phloretin is very little, Phloretin is mostly in the form of its glycoside derivatives -  Phlorhizin, the human body absorbed

Phloretin Bioactivities                                                                                                              

1.Phloretin has the effect of Antioxidant, anti-free radical effect

Flavonoids have anti-oil oxidation activity, as early as the 1960s has been proved: many flavonoid compounds polyhydroxy structure can be chelated with metal ions through the significant antioxidant properties.

2. Phloretin has the effect of Whitening and lightening effect

Numerous research results show that the whitening mechanism of phloretin is mainly to inhibit the activity of tyrosinase, which in turn reduces the production of melanin in the body.

Tyrosinase, as we know, is an important catalysing enzyme for the synthesis of melanin, and the inhibitory activity of rhizoderma lucidum on tyrosinase is very high, and the effect is better than arbutin and kojic acid .

3.Phloretin is inTransdermal absorption

One of the reasons why Phloretin, a lipophilic compound, can penetrate into the skin via intercellular lipids is that it can alter the membrane dipole potential of the phospholipid bilayer, affecting the interfacial organisation of the bilayer and the kinetics of the osmotically-driven water flow of water.

It was also found that when the transdermal absorption experiment of hydrochloride was done with Phloretin as a medium, the amount of absorption was 5.4 times higher than the original one; in the experiments of Phloretin and phlorizin on the absorption of intestinal glucuronidation, acetaminophen and 1-naphthol, the results showed that Phloretin and Phlorizin can inhibit the effect of glucuronidation and promote the absorption of acetaminophen and 1-naphthol in the small intestine, so that the pharmacological activities of them can be Significantly increased

4.Phloretin has the function of Anti-inflammatory activity

We know that when the skin barrier is compromised, the penetration of irritants is enhanced and induces the release of pro-inflammatory and chemokines from different cells to regulate the progression of immunity and inflammation, which in turn contributes to the development of sensitive skin. It is therefore concluded that inhibition of the production of inflammatory and chemokine factors can inhibit or reduce the damage caused by skin tissues during the inflammatory response.

As for the anti-inflammatory experiments of Phloretin, there are in vitro studies that show that Phloretin is able to inhibit the production of inflammatory factors, chemokines and differentiation of the signalling protein kinases Akt and MAPK, so as to achieve the anti-inflammatory effect.

Not only that, but modern medicine has shown that the important factors associated with the pathogenesis of acne and the triggers of inflammation are often not isolated.

The topical application of phloretin can prevent sugar components from entering the epidermal cells and inhibit the overproduction of skin glands, thus achieving the effect of treating hypersecretory acne. At the same time, the entry of phloretin into the cells can significantly reduce the COX-2 promoter activity, inhibit the production of prostate E2, and alleviate the inflammatory response of acne-prone skin.