Dexmedetomidine Hydrochloride0

Pls inpChinese name: Dexmedetomidine Hydrochloride. Chinese synonym: Dexmedetomidine Hydrochloride Α 2 adrenergic receptor agonists; Dexmedetomide hydrochloride; Dexmedetomidine hydrochloride; Dexmedetomidine hydrochloride; Methomidine impurity 39; Dexmedetomidine hydrochloride; 4- [(1R) -1- (2,3-dimethylphenyl) ethyl] -3H imidazole hydrochloride; Dexmedetomidine hydrochloride, also known as dexmedetomidine hydrochloride, is synonymous with 4- [(1r) -1- (2,3-dimethylphenyl) ethyl] -3h imidazole hydrochloride; 4- (s) - alpha, 2,3-trimethylbenzyl) iminidazolemonohydrochloride; DEXMEDETOMIDINEHCL; DEXMEDETOMIDINEHYDROCHLORIDE; DEMEDTOMIDINEHCL; Dexmedetomidine (Pilot); 4- [(1S) -1- (2,3-dimethylphenyl) ethyl] -1H imidazolehydrochloride; 4- (S)- α, 2,3-Trimethylbenzyl) iminidazolemonohydrochlorideCAS number 145108-58-3, molecular formula C13H17ClN2, molecular weight 236.74, EINECS number 682-047-2, related categories of traditional Chinese medicine reference materials; Neural signals; Active pharmaceutical ingredients; Medical raw materials; Intermediate; Signal transduction pathway kinase inhibitors; Small molecule inhibitors, natural products; Antipyretic and analgesic; Analgesics; Research reagents; Drug impurities and intermediates; Other active pharmaceutical ingredients; Inhibitors; API; Impurity reference substance; Standard products; Raw material Mol file 145108-58-3. Mol structural formula dexmedetomidine hydrochloride properties Melting point 156.5-157.5 ° Specific rotation+52.4 ° (c=1 in water) Density 1.17g/cm3 Storage conditions 2-8 ° C Solubility in water is 20mg/mL, clear form Powder color white to beige Optical activity[ α]/ D+48to+58 °, c=1inH2OMerck142946 Stability hygroscopicity InchIInChI=1/C13H16N2. ClH/c1-9-5-4-6-12 (10 (9) 2) 11 (3) 13-7-14-8-15-13/ H4-8,11H, 1-3H3, (H, 14,15); 1H/t11-/ S3InChIKeyVPNGEIHDPSLNMU-MERQFXBChemicalbookCSA NSMILES [C @ @ H] (C1NC=NC=1) (C1C=CC=C (C) C=1C) C.Cl |&1:0, r | CAS database Facebook and Whatapp +8618397614799, Threema:F785WMTH145108-58-3 (CASDataBaseReference) Overview of the use and synthesis methods of dexmedetomidine hydrochloride Dexmetomidine hydrochloride is a highly selective adrenergic receptor agonist, Mainly used for sedation during tracheal intubation and mechanical ventilation in hand surgery patients undergoing general anesthesia, as well as sedation for patients undergoing intubation and mechanical ventilation during critical illness monitoring and treatment. Dexmedetomidine hydrochloride is the only sedative drug that can be awakened during surgery, with certain anti anxiety, analgesic, and diuretic effects. It has the advantages of low respiratory depression, low delirium incidence, and protection of organs such as the heart/kidney/brain. Currently, it has been recognized in the "Chinese Adult ICU Analgesic and Sedative Treatment Guidelines (2018)" and the "Expert Consensus on Dexmedetomidine in Cardiovascular Anesthesia and Perioperative Application (2018)" The Clinical Practice Guidelines: Management of Pain, Agitation/Sedation, Delirium, Fixation, and Sleep Interruption in Adult Patients in the ICU (2018) and other authoritative guidelines and expert consensus at home and abroad are widely recommended for departments such as surgery, anesthesia, ICU, ophthalmology, and pediatrics. Dexmedetomidine hydrochloride injection is a variety listed in the 2020 National Medical Insurance Catalogue, with a sales revenue of 3.6 billion yuan in China in 2019. At present, three new anesthesia and pain relief products, namely injection of Parexib sodium, dexmedetomidine hydrochloride injection, and propofol medium/long-chain fat emulsion injection, have been approved, and a preliminary product cluster has been formed in this field. Drug related effects and the use of anesthetics and sedatives can improve drug efficacy, and attention should be paid to reducing the dosage appropriately. This product cannot be added to blood products or administered through the same infusion tube. The dosage and dosage of intramuscular injection last for 2-3 hours and is not suitable for short surgeries. The intravenous injection takes effect for 30 minutes and lasts for 4 hours. Common static injection initial quantity 1 μ Dilute the injection 50 times with 0.9% sodium chloride injection at a concentration of g/kg, inject within 10 minutes, and then maintain 0.2-0.7 by intravenous drip μ G/kg. Postoperative analgesia can be used 0.4 times per session μ G/kg, no more than 5 times within 2 hours. The application of dexmedetomidine hydrochloride is used for pain relief, sedation, and facilitates surgery and mechanical ventilation. The incidence of bradycardia is relatively high, and excessive sedation is more common, which affects its widespread use. Biological activity DexmedetomidineHCl is an effective and highly selective method α- 2 adrenergic receptor agonists have a significant sedative effect, thereby reducing the amount of anesthesia in patients. TargetValue alpha-2 receptor side effects: After using dexmedetomidine hydrochloride, animal blood pressure will increase and then return to normal or slightly below normal levels. It can also lead to a decrease in respiratory rate and body temperature. The degree and process of temperature reduction are related to the dosage of medication. It may cause a slowdown in gastrointestinal peristalsis, as well as an increase in blood sugar caused by stem inhibition of the release of dipyridamole, leading to an increase in urine output. Application: A sedative; Analgesicsut...