Bexarotene
ISO 1 Inquiries
153559-49-0
pharmaceutical grade
98%
25kg/Cardboard Drum
Yes
2024-07-13
Dyes,Textile agent,Medical intermediate,API,Pigments,Basic Chemicals
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Product Description
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferenceWhite SolidBexarotene was launched in the US for the treatment of manifestations of cutaneous T-cell lymphoma in patients who are refractory to at least one prior systemic therapy. The four step synthesis of bexarotene involves a double Friedel-Craft alkylation of toluene with 2,5-dichloro-2,5-dimethylhexane followed by acylation with monomethylterephthalic acid chloride, then Wittig methylidenation. Bexarotene is the first retinoid X receptor (RXR) agonist to be selective versus retinoid
Solid
Bexarotene is a retinoid, a member of benzoic acids and a member of naphthalenes. It has a role as an antineoplastic agent.|Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma.|Bexarotene is a Retinoid.|Bexarotene is a retinoid analogue that is used to treat the skin manifestations of cutaneous T cell lymphoma (CTCL). Bexarotene therapy is associated with a high rate of serum enzyme elevations and rare instances of clinically apparent acute liver injury.|Bexarotene is a synthetic retinoic acid agent with potential antineoplastic, chemopreventive, teratogenic and embryotoxic properties. Bexarotene selectively binds to and activates retinoid X receptors (RXRs), thereby inducing changes in gene expression that lead to cell differentiation, decreased cell proliferation, apoptosis of some cancer cell types, and tumor regression. (NCI04)|A rexinoid (an RXR-binding ligand), tetrahydronaphthalene derivative and RETINOID X RECEPTOR antagonist that is used in the treatment of CUTANEOUS T-CELL LYMPHOMA.CertificatesBasic Info-
Product Name:
Bexarotene
Other Name:Benzoic acid,4-[1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]-;4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid;LGD 1069;LG 1069;LG 100069;Bexarotene;Targrexin;Targretyn;RO 26-4455;LG 69;Targretin;LG 69 (retinoid);Targret;SR 11247
CAS No.:153559-49-0
Molecular Formula:C24H28O2
InChIKeys:InChIKey=NAVMQTYZDKMPEU-UHFFFAOYSA-N
Molecular Weight:348.48
Exact Mass:348.48
UNII:A61RXM4375
NSC Number:747528
DSSTox ID:DTXSID1040619
NCI Thesaurus Code:C1635
Color/Form:Off-white to white powder
ATC Code:L01XF03|L01XX25|L - Antineoplastic and immunomodulating agents
HScode:29163990
Categories:
Characteristics-
PSA:
37.3
XLogP3:7.6
Appearance:white to beige
Density:1.042
Melting Point:224-226 °C @ Solvent: Ethyl acetate, Hexane
Boiling Point:489.7±44.0 °C(Predicted)
Flash Point:229.5±23.1 °C
Refractive Index:1.556
Water Solubility:Soluble in DMSO and ethanol
Storage Conditions:-20°C Freezer
Vapor Pressure:3.5X10-9 mm Hg at 25 deg C (est)
Henrys Law Constant:Henry's Law constant = 8.1X10-9 atm-cu m/mol at 25 °C (est)
Dissociation Constants:pKa = 4.2 (carboxylic acid) (est)
Experimental Properties:Also reported as white crystals, mp 234 °C|Hydroxyl radical reaction rate constant = 6.9X10-11 cu cm/molecule-sec at 25 °C (est)
Hazard IdentificationClassification of the substance or mixture
Reproductive toxicity, Category 2
GHS label elements, including precautionary statements
Pictogram(s)
Signal word Warning
Hazard statement(s) H361 Suspected of damaging fertility or the unborn child
Precautionary statement(s) Prevention P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Dyes,Textile agent,Medical intermediate,API,Pigments,Basic Chemicals
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Location:
Room 507, Dongnan Technology R&D Center, No.438 Jincheng Road, Beigan Street, Xiaoshan District,Hangzhou City,Zhengjiang Province,China
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Payment Terms:
TT against copy of documents,L/C,100% TT in advance
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Average lead Time:
20 days
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Total Annual Revenue:
$25 million-$50 million
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Total Employees:
51-100
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Year of Establishment:
2013
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Inquiry History1 Inquiries
Country Product Purchase Quantity Date Posted
Pakistan
Bexarotene
150 G Jun 23, 2025 Post an enquiry for this product
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