114899-77-3 | ChemExpress
114899-77-3
shanghai
10 kg
2024-04-01
CRO
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceChEBI: A tetrahydroisoquinoline alkaloid obtained from a Caribbean tunicate Ecteinascidia turbinata. Used for the treatment of soft tissue sarcoma and relapsed ovarian cancer.Trabectedin is a marine natural product derived from the tunicate Ecteinascidia turbinate. With its demonstrated in vitro and in vivo activity against a range of solid tumor cell lines, human xenografts and tumor explants, this antineoplastic agent has been developed and launched for the treatment of advanced STS after
Trabectedin is natural product derived from the Caribbean sea squirt which has antineoplastic activity and is used to treat soft tissue sarcoma. Trabectedin therapy is associated with a high rate of transient serum enzyme elevations during treatment and with occasional instances of clinically apparent liver injury with jaundice.|A complex structure that includes isoquinolines joined by a cyclic ester; it is a DNA-binding agent and guanine N2 alkylator derived from the marine tunicate, Ecteinascidia turbinata. Trabectedin is used for the treatment of advanced soft-tissue SARCOMA, after failure of ANTHRACYCLINES or IFOSFAMIDE drug therapy.Basic Info-
Product Name:
Trabectedin
Other Name:Spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1′(2′H)-isoquinolin]-19-one,5-(acetyloxy)-3′,4′,6,6a,7,13,14,16-octahydro-6′,8,14-trihydroxy-7′,9-dimethoxy-4,10,23-trimethyl-,(1′R,6R,6aR,7R,13S,14S,16R)-;Spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1′(2′H)-isoquinolin]-19-one,5-(acetyloxy)-3′,4′,6,6a,7,13,14,16-octahydro-6′,8,14-trihydroxy-7′,9-dimethoxy-4,10,23-trimethyl-,[6R-(6α,6aβ,7β,13β,14β,16α,20R*)]-;(1′R,6R,6aR,7R,13S,14S,16R)-5-(Acetyloxy)-3′,4′,6,6a,7,13,14,16-octahydro-6′,8,14-trihydroxy-7′,9-dimethoxy-4,10,23-trimethylspiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1′(2′H)-isoquinolin]-19-one;Ecteinascidine 743;Et 743;Ecteinascidin 743;NSC 648766;Trabectedin;Yondelis;Ecteinascidin
CAS No.:114899-77-3
Molecular Formula:C39H43N3O11S
InChIKeys:InChIKey=PKVRCIRHQMSYJX-AIFWHQITSA-N
Molecular Weight:761.845
Exact Mass:761.84
DSSTox ID:DTXSID2046880
Categories:
Characteristics-
PSA:
194.02000
XLogP3:3.10
Appearance:Solid
Density:1.55±0.1 g/cm3 (20 ºC 760 Torr)
Refractive Index:1.732
Water Solubility:3.28e-01 g/L
Specific rotation:D25 +114° (c = 0.1 in methanol)
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 2, Oral
Acute toxicity - Category 4, Dermal
Acute toxicity - Category 4, Inhalation
Germ cell mutagenicity, Category 2
Reproductive toxicity, Category 2
Specific target organ toxicity â repeated exposure, Category 2
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H300 Fatal if swallowed
H312 Harmful in contact with skin
H332 Harmful if inhaled
H341 Suspected of causing genetic defects
H361 Suspected of damaging fertility or the unborn child
H373 May cause damage to organs through prolonged or repeated exposure
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P203 Obtain, read and follow all safety instructions before use.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
Response P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P317 Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P318 IF exposed or concerned, get medical advice.
P319 Get medical help if you feel unwell.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
CRO
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Location:
1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA
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Payment Terms:
TT against copy of documents
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Average lead Time:
3
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Total Annual Revenue:
$2.5 million-$5 million
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Total Employees:
Above 1000
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Year of Establishment:
2006
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
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