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High purity Topotecan 98% with best price 123948-87-8 and Topotecan raw material

Unit Price:

$8.8-10/MT FOB

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CAS No.:

123948-87-8

Grade:

Pharmaceutical Grade

Content:

99%

Port:

shenzhen

Packaging:

1kg/bag;25kg/Cardboard Drum

Price valid (until):

2200-12-31

Contact Supplier

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Xi'an Honest BioEngr Co.,Ltd.

Company Type:

Trader

Location:

China

Payment Terms:

TT against copy of documents,100% TT in advance

Average Lead Time:

30 days

Qualification:

Main Products:

Estradiol,Progesterone,GS441524,4-Butylresorcinol,DeoxyArbutin,Coenzyme Q10

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Product Description
Seller Information

Description

Product Detail

Superiority

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address

1.High quality and competitive price.
2.Free sample for your evaluation.
3.Promptly delivery by well-reputed shipping lines.
4.Trial order is available for testing after samples.
5.We will inform you all the information at every stage in advance.
6.Packaging can gear to buyers' special request.

Our service

1. Reply your inquiry in 24 working hours.
2. Customized design is available. OEM are welcomed.
3. Exclusive and unique solution can be provided to our customer by our well-trained and professional engineers and
staff.
4. Professional factory: We are manufacturer, specializing in producing all kinds of herb extract for more than 10 years, competitive with good quantity.
5. As an honest seller, we always use superior raw material, advanced machines, skilled technicians to ensure our products to be finished in high quality and stable feature.

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FAQ

1.: Are you a factory or trading company
We are the integration of factory and trade.

2.: How is the quality I want to test.
Before production and extraction, we will test all raw materials.Quality is our top priority.All products are strictly tested and confirmed by our QC and QA, approved by Third Party Lab in China.So you will be assured with Good Quality if you choose us. We welcome you test the product and hope to get your feedback.

3.: Can I get a Free sample
Yes,We can provide free samples.For most products we can provide you a free sample, You only need to pay for Shipping. Plesae be free to consult our salesman.
For a larger quantity, we always support you with better price, and we will have some discount in some especial days.

4. : What's your main payment method
T/T (Bank transfer), Wechat,Alipay,Credit card payment.

5. : Have you received my payment How long will it take
Generally, we can receive your payment the next day, and we will inform you as soon as we receive your payment.
After confirmation payment, we will send out package

6.:When will you sent out the goods after successful payment
Normally the order will be delivery within 1-3 days after the order confirmed, except the customized products.

7.:What modes of transportation do you have to choose
We cooperate with HKEMS, DHL, TNT, UPS, FEDEX, EMS, China Air Post ,sea transportation etc.
And with the SAFE SHIPPING in each country, you can receive the goods smoothly.It is fast and safe method.

8.:How long does it take to the goods arrived
It is Depending on your location:
For small order, please expect 5-7 days by DHL,UPS,TNT, FEDEX, HKEMS,Netherlands post.
For large order, please allow 5-8 days by Air, 20-35 days by Sea
At the same time, we have warehouses in Germany and California, and some orders can be sent directly from Germany or California.

9.:How is the goods packed
We usually send goods with disguise package outside and a double-layer sterile transparent bag inside.We have tried thousand of package methods, it looks serious and discreet.

10.: How can I get a discount
Our products have already given you a discount, and the price is favorable. Orders above $1,000 can enjoy 95% discount, transportation discount or additional sample products. Therefore, for larger quantities, we always support better prices.

11.: How to proceed order
Please Let me konw the product you are looking for,quantity and the destination country wihch help me to give you a right price;
After you confirm all details of order, pay money in advance and give us Shipping address.We arrange the shipment at first time after receive payment and offer after-sales service after you receive parcel.

12.:When will I receive the shipping number Where I can check status of my order
After the goods are sent out, our staff will send you the shipping number via email, online or WhatsApp ASAP.You can also check the status online on 17track.

13.:Is a signature required for the shipping?
Our shipping method requires no signature from your side upon delivery.

ECHEMI Editorial Reference

Topotecan (SKF 104864A; NSC 609669) is a Topoisomerase I inhibitor. The IC50 values of Topotecan at 24 h are 2.73±0.25 μM of U251 cells, 2.95±0.23 μM of U87 cells, 5.46±0.41 μM of GSCs-U251 and 5.95±0.24 μM of GSCs-U87.
Solid
Topotecan is a pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks. It has a role as an EC 5.99.1.2 (DNA topoisomerase) inhibitor and an antineoplastic agent.|An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I.|Topotecan is a Topoisomerase Inhibitor. The mechanism of action of topotecan is as a Topoisomerase Inhibitor.|Irinotecan and topotecan are semisynthetic derivatives of the plant alkaloid camptothecin and are used as antineoplastic agents in the therapy of colorectal, ovarian and non-small cell lung cancer. Both irinotecan and topotecan are associated with an appreciable rate of serum enzyme elevations during therapy, and irinotecan has been implicated in causing steatohepatitis when given as cyclic anticancer therapy.|Topotecan is a semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Topotecan inhibits topoisomerase I activity by stabilizing the topoisomerase I-DNA covalent complexes during S phase of cell cycle, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery.|An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA TOPOISOMERASES, TYPE I.

Basic Info

Product Name:

Topotecan

Other Name:

1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-,(4S)-;1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-,(S)-;(4S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;Topotecan;Hycamptamine;SKF 104864;Topotecan lactone;SKF-S 104864;Hycamptin;NSC 609699;10-Hydroxy-9-[(dimethylamino)methyl]-(20S)-camptothecin;9-(N,N-Dimethylaminomethyl)-10-hydroxycamptothecin;(S)-Topotecan;Nogitecan;Topophore C;TopoCED;(19S)-8-[(Dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0[2,11].0[4,9].0[15,20]]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione;Potactasol;Evotopin;133242-28-1;138121-88-7

CAS No.:

123948-87-8

Molecular Formula:

C23H23N3O5

InChIKeys:

InChIKey=UCFGDBYHRUNTLO-QHCPKHFHSA-N

Molecular Weight:

421.45

Exact Mass:

421.45

EC Number:

231-595-7

UNII:

7M7YKX2N15

NSC Number:

641007

DSSTox ID:

DTXSID3042685

NCI Thesaurus Code:

C1413

ATC Code:

L01CE01|L01XX17|L - Antineoplastic and immunomodulating agents

HScode:

2942000000

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

103

XLogP3:

0.5

Appearance:

yellow liquid

Density:

1.5±0.1 g/cm3

Melting Point:

−114 °C(lit.)

Boiling Point:

>100 °C(lit.)

Flash Point:

12 °C

Refractive Index:

1.734

Water Solubility:

H2O: soluble

Storage Conditions:

2-8°C

Vapor Pressure:

613 psi ( 21.1 °C)

Vapor Density:

1.3 (vs air)

Henrys Law Constant:

Henry's Law constant = 1.59X10-24 atm-cu m/mol at 25 °C (est)

Dissociation Constants:

pKa1 = 1.74 (imine); pKa2 = 8.00 (benzyl alcohol); pKa3 = 9.83 (amine) (est)

Experimental Properties:

Light yellow to greenish powder, mp 213-218 °C (decomposes). Soluble in water up to 1 mg/mL. Hygroscopic. Heant and light sensitive /Topotecan hydrochloride/|Hydroxyl radical reaction rate constant = 2.63X10-10 cu cm/molec-sec at 25 °C (est)|Ozone radical reaction rate constant = 1.16X10-15 cu cm/molec-sec at 25 °C (est)

See More Topotecan Properties 

Hazard Identification

Classification of the substance or mixture

Germ cell mutagenicity, Category 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H341 Suspected of causing genetic defects
Prevention	P203 Obtain, read and follow all safety instructions before use. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response	P318 IF exposed or concerned, get medical advice.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Topotecan Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Estradiol,Progesterone,GS441524,4-Butylresorcinol,DeoxyArbutin,Coenzyme Q10

Location:
XINYUAN DADUHUI PHASE 1, NO.258 TAOYUAN NORTH ROAD, LIANHU DISTRICT, XI 'AN , SHAANXI CHINA

Payment Terms:
TT against copy of documents,100% TT in advance

Average lead Time:
30 days

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
11-50

Year of Establishment:
2023

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High purity Topotecan 98% with best price 123948-87-8 and Topotecan raw material

Product Description

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