Magnesium stearate CAS 557-04-0 / MAGNESIUM OCTADECANOATE 99% White Powder

Chemical Identity: Magnesium Stearate (CAS No. 557-04-0) Description: Magnesium stearate is a magnesium salt of stearic acid, a saturated fatty acid composed of a long hydrocarbon chain (C18) with a terminal carboxyl group. It is widely used as a lubricant, anti-adherent, and flow agent in various industries.

Physical Properties: Description: Magnesium stearate is typically found as a fine, white, or off-white powder with a soft, greasy texture. It is insoluble in water but soluble in organic solvents like ethanol and benzene. It has a melting point of approximately 88-110°C.

Chemical Structure: Description: The chemical structure of magnesium stearate consists of two stearic acid molecules (C18H36O2) combined with a magnesium cation (Mg2+) through ionic bonding, forming a white crystalline compound.

Synthesis Method: Description: Magnesium stearate is synthesized through the reaction between stearic acid and magnesium salts such as magnesium hydroxide or magnesium carbonate. The reaction typically occurs in the presence of heat and catalysts, followed by purification steps to obtain the final product.

Applications in Industry: Description: Magnesium stearate is widely used as a lubricant and anti-adherent in the pharmaceutical, food, and cosmetic industries. It is commonly added to tablet and capsule formulations to improve flow properties during manufacturing and prevent sticking to equipment.

Pharmaceutical Applications: Description: In pharmaceuticals, magnesium stearate is used as a pharmaceutical excipient in solid dosage forms such as tablets and capsules. It aids in tablet compression, improves powder flowability, and reduces friction between particles, facilitating uniform distribution of active ingredients.

Toxicological Considerations: Description: Magnesium stearate is generally regarded as safe for use in pharmaceuticals and food products at appropriate concentrations. It is non-toxic and not absorbed significantly in the gastrointestinal tract. However, inhalation of large amounts of dust may cause respiratory irritation.

Regulatory Status: Description: Magnesium stearate is regulated by government agencies such as the FDA in the United States and the European Food Safety Authority (EFSA) in the European Union. It is approved for use as a food additive and pharmaceutical excipient within specified limits.

Environmental Impact: Description: Magnesium stearate is considered environmentally safe and biodegradable. It does not pose significant risks to aquatic organisms or ecosystems. However, proper disposal practices should be followed to minimize environmental impact.

Safety Precautions: Description: When handling magnesium stearate in powder form, it is recommended to wear appropriate respiratory protection to avoid inhalation of dust particles. Avoid prolonged skin contact, as it may cause mild irritation. Store magnesium stearate in a cool, dry place away from sources of ignition and incompatible materials.