Curcumin CAS NO (458-37-7) available for sale in bulk

Curcumin, known by its CAS number 458-37-7, is a bioactive compound extracted from the rhizome of the turmeric plant (Curcuma longa). It is a polyphenolic compound belonging to the curcuminoid family and is responsible for the vibrant yellow-orange color of turmeric. Curcumin has been extensively studied for its diverse pharmacological properties and potential health benefits.

1. Chemical Structure: Polyphenolic Compound Curcumin is a polyphenolic compound characterized by its diarylheptanoid structure, consisting of two aromatic rings connected by a seven-carbon linker with keto-enol tautomeric forms. Its chemical structure contributes to its antioxidant, anti-inflammatory, and other biological activities.

2. Natural Source: Derived from Turmeric Curcumin is extracted from the rhizomes of the turmeric plant, a member of the ginger family (Zingiberaceae). Turmeric has been used for centuries in traditional medicine and culinary practices, particularly in South Asia, where it is valued for its medicinal properties and culinary flavor.

3. Bioavailability: Limited Absorption and Rapid Metabolism Despite its potent biological activities, curcumin exhibits poor bioavailability due to low solubility, rapid metabolism, and limited absorption in the gastrointestinal tract. Strategies such as nanoformulation, liposomal encapsulation, and co-administration with bioenhancers have been explored to improve its bioavailability.

4. Antioxidant Activity: Scavenging Free Radicals Curcumin is a potent antioxidant that scavenges free radicals and reactive oxygen species (ROS), helping to protect cells and tissues from oxidative damage. Its antioxidant properties contribute to its anti-aging, neuroprotective, and cardioprotective effects.

5. Anti-Inflammatory Effects: Modulating Inflammatory Pathways Curcumin exhibits anti-inflammatory effects by inhibiting pro-inflammatory cytokines, enzymes, and signaling pathways involved in the inflammatory response. It suppresses the activation of nuclear factor-kappa B (NF-κB) and other inflammatory mediators, thereby mitigating inflammation and related conditions.

6. Pain Relief: Analgesic and Anti-Nociceptive Properties Curcumin has analgesic and anti-nociceptive properties, making it potentially useful for pain relief and management. It modulates pain perception and transmission by interacting with neurotransmitter systems, ion channels, and inflammatory mediators involved in nociception.

7. Neuroprotective Effects: Enhancing Cognitive Function Curcumin exerts neuroprotective effects by promoting neuronal survival, neurogenesis, and synaptic plasticity in the brain. It may help protect against neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease by reducing oxidative stress, neuroinflammation, and amyloid-beta aggregation.

8. Anti-Cancer Properties: Inhibiting Tumor Growth and Metastasis Curcumin demonstrates anti-cancer properties by inhibiting tumor cell proliferation, inducing apoptosis (programmed cell death), and suppressing angiogenesis and metastasis. It modulates multiple signaling pathways involved in carcinogenesis, making it a potential adjunctive therapy for cancer treatment.

9. Cardioprotective Effects: Improving Heart Health Curcumin has cardioprotective effects by reducing risk factors associated with cardiovascular diseases, including hypertension, dyslipidemia, and atherosclerosis. It improves endothelial function, lowers cholesterol levels, and exhibits anti-thrombotic and anti-platelet activities.

10. Clinical Applications: Therapeutic Potential Curcumin is being investigated for its therapeutic potential in a wide range of health conditions, including inflammatory disorders, metabolic syndrome, neurodegenerative diseases, cancer, cardiovascular diseases, and gastrointestinal disorders. Clinical trials are ongoing to evaluate its safety, efficacy, and optimal dosing regimens in various patient populations.