Chinese manufacture PNQ supply D-Tetrandrine
518-34-3
Chemical Grade
98%
Wuhan pnq
Aluminum foil bag
Yes
2029-12-06
Apigenin,PQQ,NMNH
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Product Details
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Seller Information
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DescriptionECHEMI Editorial ReferenceTetrandrine is a bis-benzyl-isoquinoline alkaloid, which inhibits voltage-gated Ca2+ current (ICa) and Ca2+-activated K+ current.
(+)-Tetrandrine is a member of isoquinolines and a bisbenzylisoquinoline alkaloid.|Tetrandrine is a natural, bis-benzylisoquinoline alkaloid isolated from the root of the plant Radix stephania tetrandrae. Tetrandrine non-selectively inhibits calcium channel activity and induces G1 blockade of the G1 phase of the cell cycle and apoptosis in various cell types, resulting in immunosuppressive, anti-proliferative and free radical scavenging effects. This agent also increases glucose utilization by enhancing hepatocyte glycogen synthesis, resulting in the lowering of plasma glucose. (NCI04)
Recently it has been discovered that pronounced drug-dependence and related toxic effects occur in both dogs and rhesus monkeys with this alkaloid on intravenous injection with a dose of 10-150 mg/kg. When rapidly injected, the acute hypotensive effect is very marked and fatal at once. Following drug administration at toxic levels it is found that severe local tissue reaction heptaotoxicity and lymphoid necrosis occurs. At the highest dosage level there is a very definite nephrotoxicity in monkeys and some indications of this in dogs. The evidence available suggests that monkeys are less sensitive to hepatotoxicity with this drug than dogs.
Tetrandrine is abis-benzylisoquinoline alkaloid that has been found inR. stephaniaroots and has diverse biological activities. It induces autophagy in HeLa, MCF-7, and human foreskin fibroblast (HFF) cells when used at a concentration of 5 μM, an effect that can be reversed by the autophagy inhibitor 3-methyladenine . Tetrandrine inhibits PAF-, thrombin-, collagen-, ADP-, or epinephrine-induced aggregation of isolated human platelets. Priming of mesenchymal stem cells (MSCs) with tetrandrine (5 and 10 μM) reduces TNF-α secretion by RAW 264.7 cells in co-culture. Ear skin transplantation of tetrandrine-primed MSCs decreases ear levels of TNF-α in a mouse model of ear skin inflammation. Tetrandrine (1 mg/kg) increases soleus muscle levels of glucose transporter 4 (Glut4) and decreases plasma glucose levels in a rat model of diabetes induced by streptozotocin .
White powderBasic Info-
Product Name:
D-Tetrandrine
Other Name:[4aS-(4aR*,16aR*)]-3,4,4a,5,16a,17,18,19-Octahydro-12,21,22,26-tetramethoxy-4,17-dimethyl-16H-1,24:6,9-dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline;(S S)-(+)-TETRANDRINE 98%;Conba;Jinake;(1β)-6,6',7,12-tetramethoxy-2,2'-dimethylberbaman;TETRANDRINE, (S,S)-(+)-(RG);Trandrine;16H-1,24:6,9-Dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline,3,4,4a,5, 16a,17,18,19-octahydro-12,21,22,26-
CAS No.:518-34-3
Molecular Formula:C38H42N2O6
InChIKeys:WVTKBKWTSCPRNU-KYJUHHDHSA-N
Molecular Weight:622.75
Exact Mass:622.75
EC Number:683-095-7
UNII:29EX23D5AJ
NSC Number:91771|77037
DSSTox ID:DTXSID10178062
NCI Thesaurus Code:C28952
Color/Form:Off-White
HScode:29349990
Categories:
Characteristics-
λmax:
283nm(EtOH)(lit.)
PSA:61.9
Physical Properties:Appearance: Needle-like crystals (ether). Solubility: Hardly soluble in water and petroleum ether; soluble in ether and some organic solvents. Melting point: 219– 222°C. Specific optical rotation: 285° (c=1, CHCl3); sensitive to light.
XLogP3:6.4
Appearance:solid
Density:1.1528 (rough estimate)
Melting Point:219-222 °C(lit.)
Boiling Point:662.81°C (rough estimate)
Flash Point:175.8±30.1 °C
Refractive Index:1.5300 (estimate)
Storage Conditions:Keep container tightly closed. Keep container in a cool, well-ventilated area. Do not store above 20ºC.
Specific rotation:285 º (c=1, CHCl3)
PKA:7.70±0.20(Predicted)
Collision Cross Section:245.3 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Critical Temperature & Pressure:2-8°C
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Oral
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H302 Harmful if swallowed
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
Response P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
Storage none
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
Apigenin,PQQ,NMNH
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Location:
Room 1006, Building C6, Economic Development Wanda, Caidian District, Wuhan City, Hubei Province
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Payment Terms:
100% TT in advance
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Average lead Time:
30 days
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Total Annual Revenue:
Less than $1 million
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Total Employees:
5-10
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Year of Establishment:
2021
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
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