SAFETY DATA SHEETS
According to the UN GHS revision 9
Version: 1.0
Creation Date: July 15, 2019
Revision Date: July 15, 2019
SECTION 1: Identification
1.1GHS Product identifier
| Product name | 5-chloro-2-methyl-2H-isothiazol-3-one |
1.2Other means of identification
| Product number | - |
| Other names | 5-Chloro-2-methyl-3-isothiazolone;5-Chloro-2-methyl-4-isothiazolin-3-one;Methylchloroisothiazolinone |
1.3Recommended use of the chemical and restrictions on use
| Identified uses | Industrial and scientific research use. |
| Uses advised against | no data available |
SECTION 2: Hazard identification
2.1Classification of the substance or mixture
Acute toxicity - Category 3, Oral
Acute toxicity - Category 3, Dermal
Skin corrosion, Sub-category 1B
Skin sensitization, Category 1
Serious eye damage, Category 1
Specific target organ toxicity – single exposure, Category 3
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
2.2GHS label elements, including precautionary statements
| Pictogram(s) |     |
| Signal word | Danger |
| Hazard statement(s) | H301+H311 Toxic if swallowed or in contact with skin H314 Causes severe skin burns and eye damage H317 May cause an allergic skin reaction H318 Causes serious eye damage H335 May cause respiratory irritation H400 Very toxic to aquatic life |
| Precautionary statement(s) |
| Prevention | P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P260 Do not breathe dust/fume/gas/mist/vapours/spray. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P271 Use only outdoors or in a well-ventilated area. P273 Avoid release to the environment. |
| Response | P301+P316 IF SWALLOWED: Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P316 Get emergency medical help immediately. P361+P364 Take off immediately all contaminated clothing and wash it before reuse. P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P363 Wash contaminated clothing before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P333+P317 If skin irritation or rash occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P354+P338 IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P317 Get medical help. P319 Get medical help if you feel unwell. P391 Collect spillage. |
| Storage | P405 Store locked up. P403+P233 Store in a well-ventilated place. Keep container tightly closed. |
| Disposal | P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal. |
2.3Other hazards which do not result in classification
SECTION 3: Composition/information on ingredients
3.1Substances
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
| 5-chloro-2-methyl-2H-isothiazol-3-one | 5-chloro-2-methyl-2H-isothiazol-3-one | 26172-55-4 | 247-500-7 | 100% |
SECTION 4: First-aid measures
4.1Description of necessary first-aid measures
If inhaled
Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.
Following skin contact
Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.
Following eye contact
Rinse with pure water for at least 15 minutes. Consult a doctor.
Following ingestion
Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.
4.2Most important symptoms/effects, acute and delayed
4.3Indication of immediate medical attention and special treatment needed, if necessary
Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Poisons A and B
SECTION 5: Fire-fighting measures
5.1Suitable extinguishing media
Use dry chemical, carbon dioxide or alcohol-resistant foam.
5.2Specific hazards arising from the chemical
5.3Special protective actions for fire-fighters
Wear self-contained breathing apparatus for firefighting if necessary.
SECTION 6: Accidental release measures
6.1Personal precautions, protective equipment and emergency procedures
Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak.
6.2Environmental precautions
Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided.
6.3Methods and materials for containment and cleaning up
Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.
SECTION 7: Handling and storage
7.1Precautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
7.2Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
SECTION 8: Exposure controls/personal protection
8.1Control parameters
Occupational Exposure limit values
Biological limit values
8.2Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
8.3Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Wear tightly fitting safety goggles with side-shields conforming to EN 166(EU) or NIOSH (US).
Skin protection
Wear fire/flame resistant and impervious clothing. Handle with gloves. Gloves must be inspected prior to use. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Respiratory protection
If the exposure limits are exceeded, irritation or other symptoms are experienced, use a full-face respirator.
Thermal hazards
SECTION 9: Physical and chemical properties and safety characteristics
| Physical state | Liquid |
| Colour | Crystals from ligroin (60-90 deg C) |
| Odour | no data available |
| Melting point/freezing point | 54-55 deg C |
| Boiling point or initial boiling point and boiling range | 200.2°C at 760 mmHg |
| Flammability | no data available |
| Lower and upper explosion limit/flammability limit | no data available |
| Flash point | 74.9°C |
| Auto-ignition temperature | no data available |
| Decomposition temperature | no data available |
| pH | no data available |
| Kinematic viscosity | no data available |
| Solubility | Solubility in g/100 mL solvent: water, infinite |
| Partition coefficient n-octanol/water | log Kow = 0.401 at 24 deg C |
| Vapour pressure | 0.328mmHg at 25°C |
| Density and/or relative density | 1.25 (14% aq.) |
| Relative vapour density | no data available |
| Particle characteristics | no data available |
SECTION 10: Stability and reactivity
10.1Reactivity
10.2Chemical stability
10.3Possibility of hazardous reactions
10.4Conditions to avoid
10.5Incompatible materials
10.6Hazardous decomposition products
When heated to decomposition it emits toxic vapors of NOx, SOx, and Cl-
SECTION 11: Toxicological information
Acute toxicity
- Oral: no data available
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
Serious eye damage/irritation
Respiratory or skin sensitization
Germ cell mutagenicity
Carcinogenicity
Reproductive toxicity
STOT-single exposure
STOT-repeated exposure
Aspiration hazard
SECTION 12: Ecological information
12.1Toxicity
- Toxicity to fish: LC50; Species: Lepomis macrochirus (Bluegill) weight 0.58 g; Conditions: freshwater, flow through; Concentration: 300 ug/L for 96 hr (95% confidence interval: 260-340 ug/L) /14.17% purity
- Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water Flea) age <24 hr; Conditions: freshwater, flow through; Concentration: 180 ug/L for 48 hr (95% confidence interval: 120-300 ug/L); Effect: intoxication, immobilization /14.17% purity
- Toxicity to algae: EC50; Species: Anabaena flosaquae (Blue-Green Algae); Conditions: freshwater, static; Concentration: 290 ug/L for 5 days (95% confidence interval: 190-450 ug/L); Effect: population, abundance /13.9% purity
- Toxicity to microorganisms: no data available
12.2Persistence and degradability
AEROBIC: Utilizing a CO2 evolution test with a freshly prepared activated sludge inoculum, 5-chloro-2-methyl-4-isothiazolin-3-one reached 38.8% and 62.0% CO2 evolution, at initial concentrations of 0.3 and 0.03 ppm, respectively, over a 28 day incubation period(1); the results classified the compound as inherently biodegradable and demonstrated a dependence on concentration(1). Microcosm studies found degradation of 5-chloro-2-methyl-4-isothiazolin-3-one to be primarily due to biodegradation based on tests using sterile controls(1). The half-life of 5-chloro-2-methyl-4-isothiazolin-3-one in an aerobic microcosm using river water and sediment was 17 days(1). At 1 ppm, [14C][5-chloro-2-methyl-4-isothiazolin-3-one], ring-labeled at the 4 and 5 carbons, degraded with a half-life of 5.4 hours in sandy loam soil that was incubated in the dark at 24-26 deg C for 64 days, and 75% of field moisture capacity(2). 5-Chloro-2-methyl-4-isothiazolin-3-one, present at 100 mg/L, reached 0% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(3); 5-chloro-2-methyl-4-isothiazolin-3-one is a biocide(1), and the high concentration (100 ppm) may have been toxic to the microorganisms(SRC).
12.3Bioaccumulative potential
A BCF of 5 was determined in bioaccumulation studies performed with bluegill sunfish(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
12.4Mobility in soil
Ring-labeled [4,5-14C][5-chloro-2-methyl-4-isothiazolin-3-one] was very mobile in sandy loam, silt loam, clay loam, and sand soils under aerobic conditions; with Freundlich Kd values of 0.1-1.5, and in sandy loam sediment with a Freundlich Kd value of 4.9 being measured(1). Koc values were 30-144 for the soils and 310 for the sediment(1). According to a classification scheme(2), these Koc values suggest that 5-chloro-2-methyl-4-isothiazolin-3-one is expected to have very high to high mobility in soil and moderate mobility in sediment.
12.5Other adverse effects
SECTION 13: Disposal considerations
13.1Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
14.1UN Number
| ADR/RID: UN1760 (For reference only, please check.) | IMDG: UN1760 (For reference only, please check.) | IATA: UN1760 (For reference only, please check.) |
14.2UN Proper Shipping Name
| ADR/RID: CORROSIVE LIQUID, N.O.S. (For reference only, please check.) | IMDG: CORROSIVE LIQUID, N.O.S. (For reference only, please check.) | IATA: CORROSIVE LIQUID, N.O.S. (For reference only, please check.) |
14.3Transport hazard class(es)
| ADR/RID: 8 (For reference only, please check.) | IMDG: 8 (For reference only, please check.) | IATA: 8 (For reference only, please check.) |
14.4Packing group, if applicable
| ADR/RID: I (For reference only, please check.) | IMDG: I (For reference only, please check.) | IATA: I (For reference only, please check.) |
14.5Environmental hazards
| ADR/RID: Yes | IMDG: Yes | IATA: Yes |
14.6Special precautions for user
14.7Transport in bulk according to IMO instruments
SECTION 15: Regulatory information
15.1Safety, health and environmental regulations specific for the product in question
| Chemical name | Common names and synonyms | CAS number | EC number |
| 5-chloro-2-methyl-2H-isothiazol-3-one | 5-chloro-2-methyl-2H-isothiazol-3-one | 26172-55-4 | 247-500-7 |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. |
| EC Inventory | Listed. |
| United States Toxic Substances Control Act (TSCA) Inventory | Listed. |
| China Catalog of Hazardous chemicals 2015 | Not Listed. |
| New Zealand Inventory of Chemicals (NZIoC) | Listed. |
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. |
| Vietnam National Chemical Inventory | Listed. |
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. |
| Korea Existing Chemicals List (KECL) | Listed. |
SECTION 16: Other information
Information on revision
| Creation Date | July 15, 2019 |
| Revision Date | July 15, 2019 |
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
| Items | Specifications |
| Appearance | Transparent amber liquid |
| Active substance content % | 14.0-15.0 |
| Density (20℃) g/cm3 | 1.24-1.32 |
| pH (stock solution) | 2.0-4.0 |
| CMI/MI (mass percentage) | 2.5-3.4 |
East Chemsources Limited was established in 2008, is a professional company engaged in the development of chemical products. In the past of 15 years，through continuous technological innovation and the use of talent introduction advantages, we have achieved rapid development, and has become an international diversified modern chemical enterprise. At present, our products have been exported to more than 80 countries,including food additives, medical raw materials, chemical products and personal care
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ECHEMI Editorial Reference
5-Chloro-2-methyl-4-isothiazolin-3-one is a heterocyclic fungicide with strong inhibitory and killing effects on common bacteria, fungi, algae, etc. Its boiling point is 200.2°C at 760 mmHg and its flash point is 74.9°C. Its bactericidal principle mainly relies on the active part on the heterocyclic ring to destroy the DNA molecules in the bacterial cells, making the bacteria inactive. 5-Chloro-2-methyl-4-isothiazolin-3-one is miscible with chlorine and most anionic, cationic and non-ionic surfactants.
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