Niacinamide-

Nicotinamide

3-Pyridinecarboxamide;Nicotinamide;Aminicotin;Benicot;Delonin Amide;Dipegyl;NAM;Niacinamide;Nicamindon;Nicofort;Nicotilamide;Nicotine acid amide;Nicotinic acid amide;Nicotinic amide;Nicotylamide;Niocinamide;Niozymin;Pelonin amide;3-Pyridinecarboxylic acid amide;Vi-Nicotyl;Vitamin B3 (niacinamide);Vitamin B;Nicosan 2;3-Carbamoylpyridine;Pelmine;β-Pyridinecarboxamide;Nicobion;Nicosylamide;Nicovit;Niavit PP;Nicovitina;Nicamina;Nicasir;3-(Aminocarbonyl)pyridine;m-(Aminocarbonyl)pyridine;3-Amidopyridine;Papulex;Nictoamide;Pelmin;NSC 13128;NSC 27452;Vitamin B3 (nicotinamide);123574-63-0;37321-14-5;78731-47-2

98-92-0

C6H6N2O

InChIKey=DFPAKSUCGFBDDF-UHFFFAOYSA-N

122.12500

122.12

202-713-4

25X51I8RD4

1405

1703

759115|27452|13128

DTXSID2020929

C2327

White, powder, needles from benzene|Colorless crystalline solid|White, crystalline powder|Colorless needles

A11HA01|A - Alimentary tract and metabolism

2933399090

Bulk Drug Intermediates

55.98000

0.88080

Nicotinamide is a white powder. (NTP, 1992)

1.400 g/cm³ @ Temp: 25 °C

130 °C

157 °C @ Press: 5 x 10^-4 Torr

182°C

1.4660 (estimate)

1000 g/L (20 ºC)

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Vapour pressure, kPa at 35°C: 3.1

Relative vapour density (air = 1): 4.2

LD50 s.c. in rats: 1.68 g/kg (Brazda, Coulson)

Odorless

Bitter taste

10% "wt in vol" solution in water is neutral to litmus

3.35(at 20 °C)

Henry's Law constant = 2.90X10-12 atm-cu m/mol at 25 °C (est)

3.35 (at 20 °C)|pKa = 3.35 (conjugate acid)|kb1 = 2.24X10-11; kb2 = 3.16X10-14

125.3 Ų [M+H]+ [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|129.32 Ų [M+H]+ [CCS Type: DT, Method: stepped-field]|137.3 Ų [M+Na]+ [CCS Type: DT, Method: stepped-field]|118 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine]|125.3 Ų [M+H]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|121.7 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]|125.2 Ų [M+H]+ [CCS Type: DT, Method: single field calibrated]|126.7 Ų [M+H]+

Readily hydrolyzed to free acid by heating in acid or alkaline solution|Forms crystalline salts with acids|Hydroxyl radical reaction rate constant = 2.34X10-12 cu cm/molec sec at 25 °C (est)

Water soluble.

Amides and Imides

An amine and amide. Acts as a weak base in solution. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

480 °C

Dust explosion possible if in powder or granular form, mixed with air.