Sulfur trioxide

80.06

80.06

231-197-3

HH2O7V4LYD

1202

1829

DTXSID1029673

White needles|Asbestos-like needles|Pure sulfur trioxide is a colorless liquid that fumes in air at room temperature and pressure.

83.30000

0.29180

Sulfur trioxide, is a colorless to white crystalline solid which will fume in air. Often shipped with inhibitor to prevent polymerization. It reacts violently with water to form sulfuric acid with the release of heat. It is corrosive to metals and tissue. It causes eye and skin burns. Ingestion causes severe burns of mouth esophagus and stomach. The vapor is very toxic by inhalation. It is a fire risk when in contact with organic materials such as wood, cotton, fiberboard, etc.

1.9 g/cm³

16.8 °C

45 °C

H2O: reacts violently

Indoors

280 mm Hg ( 25 °C)

2.8 (vs air)

Inhalation-Human TCL0: 30 mg/m3; Inhalation-Guinea Pig LC50: 50 mg/m3

Combustible in case of organic matter

Heating of high melting sulfur trioxide in glass vessels should be avoided to prevent possible shattering of the container.[The Merck Index, Fourteenth Edition (2006)

Reacts with water|Physical form: colorless solid or liquid; melting point: 16.8 °C; boiling point: 44.5 °C; density: 1.90 g/cu cm; reacts with water /gamma-form/|Physical form: white needles; melting point: 30.5 °C; boiling point: 44.5 °C; reacts with water /beta-form/|Sulfur trioxide can exist in both monomeric and polymeric forms. In the gaseous and liquid state, pure SO3 is an equilibrium mixture of monomeric SO3 and trimeric S3O9, also called Y-SO3.|Traces of moisture ... cause liquid SO3 to polymerize first to a low melting, asbestos-like form, beta-SO3 /which/ forms crystal with a silky luster. Additional reaction involves cross-linking of beta-SO3 to form a high melting, asbestos-like form, alpha-SO3 ... crystals resemble ice needles. An additional form has been mentioned ... as vaselinartiges ie, vaseline-like or gelatinous|Critical volume: 127 cu cm/mol|Heat of fusion: 8.60 kJ/mol /gamma-form/|Dielectric constant: 3.11 at 291.2 K|Melted sulfur trioxide exists in the gamma-form and on solidifying tends to the alpha form. The difference in vapor pressures explains the so-called "alpha explosion" of sulfur trioxide. Absolutely dry sulfur trioxide shows no acid reaction.|For more Other Experimental Properties (Complete) data for Sulfur trioxide (11 total), please visit the HSDB record page.|Physical form: ice-like mass; melting point: 16.8 °C or liquid; density: 1.9224; boiling point: 44.8 °C at 760 mm Hg; vapor pressure: 433 mm Hg at 25 °C /gamma-form/|Oxidizing agent, fire risk in contact with organic materials, an explosive increase in vapor pressure occurs when the alpha-form melts.

Combines with water with explosive force, forming sulfuric acid. Sulfur trioxide chars most organic substances. On exposure to air it absorbs moisture rapidly, emitting dense white acidic fumes, mists [Merck 11th ed. 1989].

Acids, Strong Oxidizing

Strong Oxidizing Agent

The reaction of SULFUR TRIOXIDE and oxygen difluoride is very vigorous and explosions occur if the reaction is carried out in the absence of a solvent [J. Chem. Eng. Data 13(4):529-531. 1968]. The reaction of sulfur trioxide in excess with tetrafluoroethylene causes explosive decomposition to carbonyl fluoride and sulfur dioxide [Chem. Eng. News 49(22):3. 1971]. The reaction of anhydrous perchloric acid with sulfur trioxide is violent and accompanied by the evolution of considerable heat (Pascal 16:300 1931-34). Liquid sulfur trioxide reacts violently with nitryl chloride, even at 75° C. The reaction of sulfur trioxide and lead oxide causes white luminescence [Mellor 7:654 1946-47]. The combination of iodine, pyridine, sulfur trioxide, and formamide developed a gas over pressurization after several months. This is due to the slow formation of sulfuric acid, from external water or dehydration of the formamide to hydrogen cyanide.

The vapour is heavier than air.

Absolute dry sulfur trioxide is not corrosive to metals

43.14 kJ/mol at 25 °C

Critical temperature: 491.0 K; critical pressure: 8.2 Mpa

I

8

UN 1829 8/PG 1

1

45-8-14-26-34-37-35

53-17-26-36/37/39-45-8-25-30

WT4830000

O,T+,C

Treasury is ventilated, low temperature and dry; stored separately from organic matter, reducing matter and flammable matter

High heat explosion in case of water

Stable. Incompatible with organic materials, finely powdered metals, bases, water, cyanides and a wide variety of other chemicals. Reacts violently with water, oxygen and other chemicals - read a full data sheet before use.

P261-P280-P305 + P351 + P338-P310

H314-H335

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

The substance is a strong oxidant and reacts violently with combustible and reducing materials and organic compounds causing fire and explosion hazard. Reacts violently with water and moist air to produce sulfuric acid. The solution in water is a strong acid, it reacts violently with bases and is corrosive metals forming flammable/explosive gas (hydrogen).|On exposure to air, it absorbs moisture rapidly, emitting dense white fumes. Combines with water with explosive violence ... forming sulfuric acid.[The Merck Index, Fourteenth Edition (2006)|Dissolution of sulfur trioxide in ... /dimethyl/ sulfoxide is very exothermic and must be done slowly with cooling to avoid decomp.|... The 1:1 addition complex /dioxane & sulfur trioxide/ sometimes decomp violently on storing at ambient temp ...|For more Hazardous Reactivities and Incompatibilities (Complete) data for Sulfur trioxide (14 total), please visit the HSDB record page.

U.S. Dept Health & Human Services/Agency for Toxic Substances & Disease Registry; Toxicological Profile for Sulfur Trioxide and Sulfuric Acid (December 1998). The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects information for a hazardous substance.[Available from, as of October 15, 2009: http://www.atsdr.cdc.gov/toxpro2.html#]

Fire risk in contact with organic materials. An explosive increase in vapor pressure occurs when the alpha form melts. Combines with water with explosive violence, forming sulfuric acid. May ignite other combustible materials (wood, paper, oil, etc.). Flammable poisonous gases may accumulate in tanks and hopper cars. Runoff to sewer may create fire or explosion hazard. Forms sulfuric acid on contact with water. Avoid water and organic materials. On exposure to air, it absorbs moisture and emits dense white fumes. (EPA, 1998)|Not combustible. Heating will cause rise in pressure with risk of bursting. Gives off irritating or toxic fumes (or gases) in a fire. Risk of fire and explosion on contact with bases, combustible substances, reducing agents or water.|Carcinogens, Corrosives, Reactive - 2nd degree

|Danger|H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]|P201, P202, P260, P261, P264, P271, P273, P280, P281, P284, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P308+P313, P310, P312, P320, P321, P363, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 466 companies from 20 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Excerpt from ERG Guide 137 [Substances - Water-Reactive - Corrosive]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: See ERG Table 1 - Initial Isolation and Protective Action Distances on the UN/NA 1829 datasheet. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 137 [Substances - Water-Reactive - Corrosive]: Fully encapsulating, vapor-protective clothing should be worn for spills and leaks with no fire. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Use water spray to reduce vapors; do not put water directly on leak, spill area or inside container. Keep combustibles (wood, paper, oil, etc.) away from spilled material. SMALL SPILL: Cover with DRY earth, DRY sand or other non-combustible material followed with plastic sheet to minimize spreading or contact with rain. Use clean, non-sparking tools to collect material and place it into loosely covered plastic containers for later disposal. Prevent entry into waterways, sewers, basements or confined areas. (ERG, 2016)

For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. (EPA, 1998)|Wear positive pressure self contained breathing apparatus. Wear appropriate chemical protective clothing.

Material itself does not burn or burns with difficulty.

Risk of fire and explosion on contact with base(s), combustible substances, reducing agents, water.|Heating of high melting sulfur trioxide in glass vessels should be avoided to prevent possible shattering of the container.[The Merck Index, Fourteenth Edition (2006)

If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire ... Use water in flooding quantities as fog. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible.|NO hydrous agents. NO water. In case of fire in the surroundings: use appropriate extinguishing media ... Cool drums, etc., by spraying with water but avoid contact of the substance with water.

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.|Evacuate danger area! Consult an expert! Do NOT absorb in saw-dust or other combustible absorbents. Absorb remaining liquid in dry sand or inert absorbent and remove to safe place. Ventilation. NEVER direct water jet on liquid. Do NOT let this chemical enter the environment.

If material not involved in fire: Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Use water spray to knock down vapors. Neutralize spilled material with crushed limestone, soda ash, or lime.|Personnel protection: Avoid breathing vapors. Keep upwind. Avoid bodily contact with the material. Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water.|SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.|SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

If ... THERE IS NO FIRE, go directly to the Table of Initial Isolation and Protective Action Distances /(see table below)/ ... to obtain initial isolation and protective action distances. IF THERE IS A FIRE, or IF A FIRE IS INVOLVED, go directly to the appropriate guide /(see guide(s) below)/ and use the evacuation information shown under PUBLIC SAFETY. /Sulfur trioxide, inhibited; Sulfur trioxide, stabilized; Sulfiur trioxide, uninhibited/|/GUIDE 137: SUBSTANCES - WATER-REACTIVE - CORROSIVE/ Health: CORROSIVE and/or TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns, or death. Fire will produce irritating, corrosive and/or toxic gases. Reaction with water may generate much heat which will increase the concentration of fumes in the air. Contact with molten substance may cause severe burns to skin and eyes. Runoff from fire control or dilution water may cause pollution. /Sulfur trioxide; Sulfur trioxide, stabilized; Sulfur trioxide, uninhibited/|/GUIDE 137: SUBSTANCES - WATER-REACTIVE - CORROSIVE/ Fire or Explosion: ... Some of these materials may burn, but none ignite readily. May ignite combustibles (wood, paper, oil, clothing, etc.). Substance will react with water (some violently), releasing corrosive and/or toxic gases. Flammable/toxic gases may accumulate in confined areas (basement, tanks, hopper/tank cars etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water. Substance may be transported in a molten form. /Sulfur trioxide; Sulfur trioxide, stabilized; Sulfur trioxide, uninhibited/|/GUIDE 137: SUBSTANCES - WATER-REACTIVE - CORROSIVE/ Public Safety: CALL Emergency Response Telephone Number ... As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75) feet for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate enclosed areas. /Sulfur trioxide; Sulfur trioxide, stabilized; Sulfur trioxide, uninhibited/|For more DOT Emergency Guidelines (Complete) data for Sulfur trioxide (9 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

A corrosive irritant to skin, eyes, and mucous membranes.|direct contact may cause irritation or chemical burns of skin, eyes, respiratory ... tracts.[The Merck Index, Fourteenth Edition (2006)|Sulfur trioxide ... causes great irritation of the eyes and resp tract, even at concn as low as 1 ppm in air.

Permissible Exposure Limit: Table Z-1 8-hr Time Weighted Avg: 1 mg/cu m. /Sulfuric Acid/

Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 1 mg/cu m. /Sulfuric Acid/

Evacuate danger area! Consult an expert! Personal protection: chemical protection suit including self-contained breathing apparatus. Ventilation. NEVER direct water jet on liquid. Do NOT let this chemical enter the environment. Do NOT absorb in saw-dust or other combustible absorbents. Absorb remaining liquid in dry sand or inert absorbent. Then store and dispose of according to local regulations.

Store only if stabilized. Separated from food and feedstuffs and incompatible materials. See Chemical Dangers. Dry. Store between 17 °C and 25 °C.

A harmful contamination of the air will be reached very quickly on evaporation of this substance at 20 °C.

The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion.

Repeated or prolonged inhalation of the aerosol may cause effects on the lungs. Repeated or prolonged inhalation of the aerosol may cause effects on the teeth. This may result in tooth erosion. Strong inorganic acid mists containing this substance are carcinogenic to humans.

NO contact with bases, combustible substances, reducing agents or water.

PREVENT GENERATION OF MISTS! AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR!

Use ventilation, local exhaust or breathing protection.

Protective gloves. Protective clothing.

Wear face shield or eye protection in combination with breathing protection.

The major hazards encountered in the use and handling of sulfur trioxide stem from its toxicologic properties and reactivity. Toxic by all routes (ie, inhalation, ingestion, and dermal contact), exposure to this colorless-to-white, crystalline solid may occur from its use in the sulfonation of oils and detergents, in the manufacture of sulfuric acid and explosives, and in solar energy collectors. Effects from exposure may include burns to the eyes, skin, and mucous membranes, shortness-of-breath, chest pain, and pulmonary edema. In activities and situations where over-exposure may occur, wear chemical protective clothing and a self-contained breathing apparatus. If contact should occur, irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes, and wash exposed skin thoroughly with soap and water. Contaminated clothing should be removed and left at the worksite for cleaning. While sulfur trioxide itself burns with great difficulty, it may react violently (explosively) with water, giving off heat and light. Also, organic materials, particularly those containing adsorbed or absorbed moisture, may be ignited by sulfur trioxide. For fires involving sulfur trioxide, extinguish with agent suitable for surrounding materials. If water is used, apply in flooding quantities as a fog, and from as far a distance as possible. Use dikes to prevent sulfur trioxide from entering water sources and sewers. Sulfur trioxide may be shipped domestically via air (cargo only), rail (cargo only), road, and water, in containers bearing the label, "Corrosive." Sulfur trioxide should be stored in air-tight containers, away from moisture. Before implementing land disposal of sulfur trioxide waste, consult with environmental regulatory agencies for guidance.

moderately toxic

LC50 Rat/male inhalation 1375 mg SO3/cu m 1 hr|LC50 Rat/female inhalation 1136 mg SO3/cu m 1 hr

Atmospheric Fate: Sulfur trioxide is a highly reactive gas, and in the presence of moisture in the air it is rapidly hydrated to sulfuric acid. In the air, therefore, it is sulfuric acid in the form of an aerosol that is found rather than sulfur trioxide, and in general, it is associated with other pollutants in droplets or solid particles extending over a wide range of sizes.

NIOSH (NOES Survey 1981-1983) has statistically estimated that 56,102 workers (3,077 of these were female) were potentially exposed to sulfur trioxide in the US(1).

Sulfite oxidation and sulfur trioxide radical formation were studied in polymorphonuclear leukocytes (PMNs) isolated from healthy young, old and centenarian donors and from patients with Down's syndrome. The sulfur radical formation ... was correlated with the activity of sulfite oxidase and with the rate of sulfite oxidation to sulfate by PMNs. Sulfite metabolism was studied both in resting, and phorbol myristate acetate (PMA) stimulated freshly isolated cells. The rate of sulfur trioxide radical formation was demonstrated by use of the spin trapping agent 5,5-dimethyl-1-pyroline-1-oxide (DMPO) with subsequent formation of an adduct. The intensity of adduct formation was most intense in cells with low sulfite oxidase activity, while a mixture of the adduct and of DMPO hydroxyl radical was mainly observed in cells with high sulfite oxidase activity. Furthermore, experiments carried out on purified sulfite oxidase showed that in the presence of sulfite the enzyme could also give rise to a DMPO-OH adduct. Sulfite oxidase activity in cells isolated from healthy young and old donors was positive correlated with both rates of sulfur trioxide radical formation and sulfite oxidation to sulfate, respectively. However, sulfite oxidase activity in cells isolated from centenarians and patients with Down's syndrome seems to lose partly its rate of oxidising sulfite to sulfate. The intensity of the sulfur centered radical adduct increased in the two latter groups of population and the radical observed was predominantly sulfur trioxide radical.

Trace amounts of water or sulfuric acid can catalyze the formation of polymers.

This material is highly toxic. It is an irritant and corrosive to mucous membranes. Poisonous if inhaled or swallowed. Contact causes severe burns to skin and eyes. (EPA, 1998)

Warning: Sulfur trioxide is extremely corrosive. Caution is advised. Signs and Symptoms of Sulfur Trioxide Exposure: Signs and symptoms of acute ingestion of sulfur trioxide may be severe and include salivation, intense thirst, difficulty in swallowing, chills, pain, and shock. Oral, esophageal, and stomach burns are common. Vomitus generally has a coffee-ground appearance. The potential for circulatory collapse is high following ingestion of sulfur trioxide. Acute inhalation exposure of sulfur trioxide may result in sneezing, hoarseness, coughing, choking, laryngitis, and respiratory tract irritation. Bleeding of nose and gums, ulceration of the nasal and oral mucosa, bronchitis, pneumonia, dyspnea (shortness of breath), chest pain, and pulmonary edema and respiratory failure may also occur. Eye exposure to sulfur trioxide may result in irritation, pain, swelling, corneal erosion, and blindness. Dermal exposure may result in dermatitis (red, inflamed skin), severe burns, and pain. Emergency Life-Support Procedures: Acute exposure to sulfur trioxide may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to sulfur trioxide. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. Transport to a health care facility. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self-exposure to sulfur trioxide. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Remove and isolate contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. 5. Wash exposed skin areas thoroughly with soap and water. 6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 7. Transport to a health care facility. Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 2. DO NOT induce vomiting or attempt to neutralize! 3. Rinse mouth with large amounts of water. Inform victims not to swallow this water. 4. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 5. Activated charcoal is of no value. 6. Give the victims water or milk: children up to 1 year old, 125 mL (4 oz or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults, 250 mL (8 oz or 1 cup). Water or milk should be given only if victims are conscious and alert. 7. Transport to a health care facility. (EPA, 1998)

Fresh air, rest. Half-upright position. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Treatment includes the use of oxygen, decontamination with special attention to the eyes, and monitoring for hypoxic ischemia. Treatment should include use of beta-agonists for bronchospasm, repeat pulmonary function tests, and monitoring for delayed pulmonary edema. Steroids, antibiotics, and nebulized sodium bicarbonate have not been adequately studied.|Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Inorganic acids and related compounds/|Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist respirations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. Activated charcoal is not effective. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Do not attempt to neutralize because of exothermic reaction. Cover skin burns with dry, sterile dressings after decontamination ... . /Inorganic acids and related compounds/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Early intubation, at the first sign of upper airway obstruction, may be necessary. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's(LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Inorganic acids and related compounds/

/SIGNS AND SYMPTOMS/ Sulfur trioxide and sulfuric acid mists are strongly irritants, and inhaling concn of approximately 3 mg/cu m causes a choking sensation. Persons accustomed to the exposure are unable to notice concn at this order of magnitude. Sulfur trioxide is irritating and corrosive to all mucous surfaces and causes inflammation of the upper respiratory tract and possible lung injury.|/SIGNS AND SYMPTOMS/ Lungs may be affected by repeated or prolonged exposure to an aerosol of this substance. Risk of tooth erosion upon repeated or prolonged exposure to an aerosol of this substance. Strong inorganic acid mists containing this substance are carcinogenic to humans.|/SIGNS AND SYMPTOMS/ Irritant and corrosive to mucous membranes. May cause coughing, choking and severe discomfort in a concn of 1 ppm.|/SIGNS AND SYMPTOMS/ Sulfur trioxide causes pulmonary skin and eye damage since it forms sulfuric acid.|For more Human Toxicity Excerpts (Complete) data for Sulfur trioxide (10 total), please visit the HSDB record page.

sulfur trioxide

The substance can be absorbed into the body by inhalation of its vapour and by ingestion.

Burning sensation. Cough. Laboured breathing. Sore throat. Wheezing. Shortness of breath.

Redness. Serious skin burns. Pain. Blisters.

Redness. Pain. Blurred vision. Severe deep burns.

Its principal applications are in production of detergents and as a raw material for chlorosulfuric acid and 65% oleum. (1983)

Under the trademark Sulfan, a product is marketed which contains 0.5% of a stabilizer to prevent polymerization to higher melting forms: Sulfan A consists largely of beta sulfur trioxide ... Sulfan B consists largely of gamma sulfur trioxide ... Sulfan C contains no stabilizer and will polymerize to alpha sulfur trioxide.|Stabilizers added include: 0.3% dimethyl sulfate with 0.005% boric oxide|Stabilized, technical, liquid grades

All other basic inorganic chemical manufacturing|Sulfur trioxide: ACTIVE|Usually generated in the plant where it is to be used

Fire Hazards -> Carcinogens, Corrosives, Reactive - 2nd degree