Factory Supply LL 37 CAS 154947-66-7 LL-37 peptide raw powder

Factory Supply LL 37 CAS 154947-66-7 LL-37 peptide raw powder

What is LL-37?

The cathelicidin anti-microbial peptide LL-37 is involved in the reepithelialization of human skin wounds and is lacking in chronic ulcer epithelium. LL-37(human) is a cathelicidin-derived peptide with antimicrobial and angiogenic activity. Antimicrobial peptide derivative of human cathelicidin

Antimicrobial peptide derivative of human cathelicidin. Induces FPRL1-mediated chemotaxis of human neutrophils, monocytes and T cells in vitro. Promotes wound healing following skin-targeted electroporation of a plasmid encoding hCAP-18/LL-37 in mice. Also triggers apoptosis in colon cancer cells. Cell permeable.

The human body mainly produces two types of antimicrobial peptides: defensin family peptides and cathelicidin family peptides. Although there are many members of the defensin family of peptides, cathelicidin has only one antimicrobial peptide product, LL-37. LL-37 is the C-terminal cleavage product of cathelicidin peptide Hcap-18, which directly kills bacteria, fungi and viruses.

Function & Applicaton

1. Antibacterial effect: LL37 can destroy the cell wall of bacteria and make it die, thus having antibacterial effect. It has antibacterial activity against a variety of gram-positive and Gram-negative bacteria, including drug-resistant bacteria.
2. Immunomodulatory effects: LL37 can regulate the function of the immune system and promote the resolution and repair of inflammation. It can enhance the activity of monocytes, macrophages and natural killer cells, and promote the regulation and repair process of immune cells in the course of inflammatory disease.
3. Anti-inflammatory effect: LL37 can reduce inflammatory response, inhibit the activation of inflammatory cells and the release of cytokines. It can regulate the expression of inflammatory mediators, thereby reducing swelling, redness, pain and other symptoms caused by inflammatory responses.
4. Promote wound healing: LL37 can promote wound healing and tissue repair. It can stimulate epidermal cell proliferation and migration, and promote the speed and quality of wound healing. At the same time, LL37 also has antioxidant and anti-angiogenesis effects, contributing to wound repair and regeneration.

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