23111-00-4 Nicotinamide riboside chloride Biochemical deoxynucleotides and their analogues
6 Inquiries
23111-00-4
Chemical Grade
99%
tianjin
longbang
25kg/Drum
2025-04-10
chemical
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Product Description
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferenceNicotinamide Riboside Chloride is the chloride salt form of nicotinamide riboside(NR).NR is a new form pyridine-nucleoside of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide(NAD) or NAD+ . Nicotinamide riboside chloride is a crystal form of Nicotinamide riboside (NR) chloride. Nicotinamide riboside chloride increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside chloride is used in dietary supplements.
Nicotinamide riboside chloride (NR-CL) is structurally a quaternary ammonium salt containing a sensitive N-glycosidic bond that spontaneously cleaves in aqueous solution, yielding nicotinamide and d-ribose degradation products (Figure 1). NR-CL exhibits three crystalline forms: Type A, Type B, and Type C. Forms A and B represent true polymorphs of the anhydrous form, whereas form C constitutes a pseudo-polymorphic form as a methanesulfonate solvate. The B form exhibits a higher crystal density (1.591 Mg/m³) and a higher melting/decomposition temperature (123°C) compared to the A form (1.512 Mg/m³, 119°C), making it the most stable crystalline form. The crystal structure of Form B(Figure 2) is orthorhombic P212121 space group, with a = 7.0008(11) Å, b = 9.6465(15) Å, c = 17.971(3) Å, V = 1213.7(3) ų, and Z = 4.
Nicotinamide riboside (NR) was first described in 1944 as a growth factor, termed Factor V, for Haemophilus influenza, a bacterium that lives in and depends on blood. Factor V, purified from blood, was shown to exist in three forms: NAD+, NMN and NR. NR was the compound that led to the most rapid growth of this bacterium.Notably, H. influenza cannot grow on nicotinic acid, nicotinamide, tryptophan or aspartic acid, which were the previously known precursors of NAD+.In 2000, yeast Sir2 was shown to be an NAD+-dependent protein lysine deacetylase, which led several research groups to probe yeast NAD+ metabolism for genes and enzymes that might regulate lifespan. Biosynthesis of NAD+ in yeast was thought to flow exclusively through NAMN (nicotinic acid mononucleotide).When NAD+ synthase (glutamine-hydrolysing) was deleted from yeast cells, NR permitted yeast cells to grow. Thus, these Dartmouth College investigators proceeded to clone yeast and human nicotinamide riboside kinases and demonstrate the conversion of NR to NMN by nicotinamide riboside kinases in vitro and in vivo. They also demonstrated that NR is a natural product found in cow’s milk.Basic Info-
Product Name:
Nicotinamide riboside chloride
Other Name:Nicotinamide riboside chloride;Nicotinamide Riboside.Cl;Nicotimide riboside chloride;Pyridinium, 3-(aminocarbonyl)-1-β-D-ribofuranosyl-, chloride (1:1);3-carbamoyl-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium chloride;3-Carbamoyl-1-(β-D-ribofuranosyl)pyridinium chloride;3-Carbamoyl-1-beta-D-ribofuranosylpyridinium chloride;Nicotinamide Riboside Chloride（NRC）
CAS No.:23111-00-4
Molecular Formula:C11H15ClN2O5
InChIKeys:YABIFCKURFRPPO-TUHHAUDNNA-N
Molecular Weight:290.7
EC Number:200-184-4
Color/Form:White
HScode:2938909090
Categories:
Characteristics-
Water Solubility:
10mg/mL, clear, colorless
Critical Temperature & Pressure:under inert gas (nitrogen or Argon) at 2-8°C
Hazard IdentificationClassification of the substance or mixture
Not classified.
GHS label elements, including precautionary statements
Pictogram(s) No symbol. Signal word No signal word
Hazard statement(s) none
Precautionary statement(s) Prevention none
Response none
Storage none
Disposal none
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
chemical
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Location:
1803-1, Block A, Huaqiang Plaza, 77 Minzu Road, Xinhua District, Shijiazhuang City, Hebei Province, China
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Payment Terms:
TT against copy of documents,L/C,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
15 days
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Total Annual Revenue:
$5 million-$10 million
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Total Employees:
51-100
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Year of Establishment:
2023
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Inquiry History6 Inquiries
Country Product Purchase Quantity Date Posted 
United States
Nicotinamide riboside chloride 98% NR 23111-00-4
5 MT Jun 22, 2024 
Pakistan
Wholesale Nicotinamide Riboside Chloride Powder 99% Powder Evergreen EGC-Nicotinamide Riboside Chloride CAS 23111-00-4
50 KG Oct 17, 2023
United States
nicotinamide riboside chloride
1 KG Feb 27, 2024 
Germany
Nicotinamide Riboside Chloride
500 Jun 22, 2026 
Philippines
NRcl
1 KG Mar 1, 2026
United States
β-Nicotinamide Riboside Chloride
1 KG Nov 22, 2024 Post an enquiry for this product
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