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Home > Active Pharmaceutical Ingredients > Veterinary Raw Materials > 5-Aminosalicylic acid for Sale > 5-Aminosalicylic Acid /5-ASA CAS 89-57-6 Mesalamine/ Mesalazine
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5-Aminosalicylic Acid /5-ASA CAS 89-57-6 Mesalamine/ Mesalazine

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Unit Price: Get Latest Price
CAS No.:

89-57-6

Grade:

Pharmaceutical Grade

Content:

99%

Port:

CHINA ANY PORT

Brand:

TNJONE

Packaging:

1kg ,25kg or according to customer's detail requirement.

Price valid (until):

2025-12-31

Company Type:
Manufactory
Location:
China
Qualification:
Main Products:

Semaglutide,Tirzepatide,API,Vitamins,Food Additive

  • Product Description

  • Seller Information

  • Inquiry History

  • Description

    5-Aminosalicylic Acid /5-ASA CAS 89-57-6 Mesalamine/ Mesalazine


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    What is 5-Aminosalicylic Acid /5-ASA/Mesalazine ?

    Mesalazine, also known as 5-aminosalicylic acid, is an organic compound with the chemical formula C7H7NO3 and is the active ingredient in SASP for the treatment of ulcerative colitis. It has a significant inhibitory effect on intestinal wall inflammation. Mesalazine can inhibit the synthesis of inflammatory prostaglandins and the formation of inflammatory mediums leukotriene, which can significantly inhibit the inflammation of intestinal mucosa. Mesalazine inhibited prostaglandin synthesis and PGE2 release in human colon mucosa in a dose-dependent manner.

    Items Specifications
    Product name  5-Aminosalicylic Acid /5-ASA/Mesalazine
    CAS No. 89-57-6
    MF C7H7NO3
    MW 153.14
    EINECS.No 201-919-1
    Melting Point 275-280 °C (dec.) (lit.)
    Boiling Point 276.03°C (rough estimate)
    Density 1.3585 (rough estimate)
    Appearance White powder
    Shelf Life 2 Years When Properly Stored
    Storage Keep in a cool, dry, dark location in a tightly sealed container or cylinder.


    Shop 5-Aminosalicylic Acid /5-ASA CAS 89-57-6 Mesalamine/ Mesalazine-Detailed Image 2 Shop 5-Aminosalicylic Acid /5-ASA CAS 89-57-6 Mesalamine/ Mesalazine-Detailed Image 3

    Certification 

    Item Specification Result
    Appearance white to off-white powder Complies
    Related substance (HPLC) Total impurity ≤0.5%
    Max single impurity ≤0.1%
    0.2%
    0.06%
    Odor Characteristic Complies
    Assay 99% 99.8%
    Sieve analysis 100% pass 80 mesh Complies
    Loss on Drying
    Residue on Ignition
    ≤1.0%
    ≤1.0%
    0.12%
    0.09%
    Heavy Metal <10ppm Complies
    As <0.1ppm 0.05ppm
    Pb <0.1ppm 0.05ppm
    Cd <0.1ppm 0.05ppm
    Residual Solvents <100ppm Complies


    Function
    High levels of prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) were found in the colon mucosa of patients with active UC. Mesalazine inhibited prostaglandin synthesis and PGE2 release in human colon mucosa in a dose-dependent manner. Mesalazine also inhibited the activity of fat oxidase in neutrophils. Two important inflammatory mediators, LTB4 and leukotriene, were dose-response inhibited by adding mesalazine to human colonic mucosal cells cultured. At high doses, mesalazine inhibits certain functions of human neutrophils, such as migration, threshing, phagocytosis, and oxygen free radical synthesis. In addition, mesalazine inhibits the synthesis of platelet motivity factors (PAFs), which play an important role in the development of inflammation. It works better on the connective tissue of the inflamed intestinal wall. It is used in ulcerative colitis, ulcerative proctitis and Crohn's disease. 


    Mesalazine can inhibit the synthesis of prostaglandins that cause inflammation and the formation of leukotriene, which can significantly inhibit the inflammation of intestinal mucosa.

    4-Aminosalicylic acid, also known as para-aminosalicylic acid (PAS) is an antibiotic primarily used to treat tuberculosis.
    The main use for 4-aminosalicylic acid is for the treatment of tuberculosis infections.
    Antimycobacterial antitubercular;NF-kB inhibitor

    Company Information 


    Shaanxi TNJONE Pharmaceutical Technology Co., LTD., located in the beautiful ancient capital of Xi 'an, is committed to pharmaceutical raw materials, kill varieties, food and feed additives, chemical reagents, plant extracts and other fields, the enterprise adhering to provide customers with quality service, supply high-quality products. Our company after careful planning, hard study, gradually formed a complete service system, based on the domestic and foreign raw materials market special development. Make the raw materials industry bigger and stronger, and serve the vast number of new and old customers. With "world peace and health" as its responsibility, the company adheres to the service concept of "meeting all requirements of customers for products", and guarantees the service principle of "providing qualified products", so that you can get the "God-like" noble shopping enjoyment. Our company has more than 500 kinds of raw materials inventory at any time to meet the various needs of customers for products. The company's products all comply with the relevant national regulations, from the smallest packaging to tons of goods are available. Is your choice of raw materials the best partner.


    Shaanxi TNJONE Pharmaceutical Technology Co., Ltd. is willing to rely on the rapid development of e-commerce and national policy support of the good environment background, nesting, welcome people from all walks of life to visit our company, exchange, and seek common development, looking forward to sharing with you, win-win, to realize the dream.


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    FAQ

    1.How to get in touch with us?

    You can chat with us by Trademanager,WhatsApp or simply giving us an email, a phone call. All our contacts information can be found from our website.

     

    2.Are you a manufacturer or trade company?

    We are a professional manufacturer.

     

    3.Can I get a sample?

    Yes, free sample can be provided, but shipping cost is covered by your side.

     

    4.What's your MOQ?

    It is based on the different product. Some are 1g while some are 1 kg. Please be free to consult our salesman.

     

    5.When can I get the quotation?
    We usually quote within 1 hours after we get your inquiry. If it's a urgent order you can call us or mention it in your email subject, and we can take it as priority.

     

    6.Is there any discount?
    Yes, some products are applied for discount, but it depends on the quantity.

     

    7.Can you do OEM for me?
    Yes,we accept OEM orders, just contact us and give us your requirement. We will offer you a reasonable price and make samples ASAP.

    Basic Info
    Product Name:

    5-Aminosalicylic acid

    Other Name:

    Benzoic acid,5-amino-2-hydroxy-;Salicylic acid,5-amino-;5-Amino-2-hydroxybenzoic acid;2-Hydroxy-5-aminobenzoic acid;3-Carboxy-4-hydroxyaniline;Pentasa;Mesalamine;5-Aminosalicylic acid;Mesalazine;Asacol;5-ASA;Salofalk;Claversal;Asacolitin;Salozinal;Mesacol;Asacolon;Fisalamine;Lixacol;Mesasal;m-Aminosalicylic acid;Rowasa;NSC 38877;Canasa;Ipocol;Asalit;Lialda;Mesalsal;Novo-5 ASA;Colasa;Apriso;Mezavant;Rovasa;Fivasa;Delzicol;61513-32-4

    CAS No.:

    89-57-6

    Molecular Formula:

    C7H7NO3

    InChIKeys:

    InChIKey=KBOPZPXVLCULAV-UHFFFAOYSA-N

    Molecular Weight:

    153.14

    Exact Mass:

    153.14

    BRN:

    2090421

    EC Number:

    201-919-1

    UNII:

    4Q81I59GXC

    NSC Number:

    759301|38877

    DSSTox ID:

    DTXSID5024506

    NCI Thesaurus Code:

    C29249

    Color/Form:

    White to pinkish crystals

    ATC Code:

    A07EC02|A - Alimentary tract and metabolism

    HScode:

    2922509090

    Characteristics
    PSA:

    83.6

    XLogP3:

    1.3

    Appearance:

    off-white to gray tablets

    Density:

    1.5±0.1 g/cm3

    Melting Point:

    283 °C

    Boiling Point:

    403.9ºC at 760 mmHg

    Flash Point:

    279-281°C

    Refractive Index:

    1.691

    Water Solubility:

    H2O: <0.1 g/100 mL at 21 ºC;soluble in dimethyl sulfoxide.

    Storage Conditions:

    2-8°C

    Vapor Pressure:

    6.10X10-8 mm Hg at 25 deg C (est)

    Toxicity:

    Peritoneal-mouse LD50: 5000 mg/kg; oral-mouse LDL0: 313 mg/kg

    Flammability characteristics:

    Flammable; burning produces toxic nitrogen oxide fumes

    Henrys Law Constant:

    Henry's Law constant = 5.02X10-12 atm-cu m/mol at 25 °C (est)

    Dissociation Constants:

    Mesalamine's production and use in the manufacture of light-sensitive paper, azo and sulfur dyes and as a gastrointestinal medication may result in its release to the environment through various waste streams. If released to air, an estimated vapor pressure of 6.1X10-8 mm Hg at 25 °C indicates mesalamine will exist in both the vapor and particulate phases in the atmosphere. Vapor-phase mesalamine will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 18 hrs. Particulate-phase mesalamine will be removed from the atmosphere by wet or dry deposition. Mesalamine does contain chromophores that absorb at wavelengths >290 nm and therefore may be expected to be susceptible to direct photolysis by sunlight. If released to soil, mesalamine is expected to have very high mobility based upon an estimated Koc of 10. Estimated pKa values of 2.09, 5.26 and 13.64 indicate that this compound will dissociate to the zwitterion form in the environment. Volatilization from moist soil surfaces is not expected to be an important fate process based upon an estimated Henry's Law constant of 5.0X10-12 atm-cu m/mole. Mesalamine is considered completely biodegradable under anaerobic conditions as was indicated by 95.6% methane production following acclimation. If released into water, mesalamine is not expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is not expected to be an important fate process based upon this compound's estimated Henry's Law constant. An estimated BCF of 3 suggests the potential for bioconcentration in aquatic organisms is low. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions. Occupational exposure to mesalamine may occur through inhalation and dermal contact with this compound at workplaces where mesalamine is produced or used. Use data indicate that the general population may be exposed to mesalamine via dermal contact with products containing this compound as well as via ingestion following administration of drugs containing mesalamine, a gastrointestinal anti-inflammatory. (SRC)

    Collision Cross Section:

    134.7 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

    Experimental Properties:

    Decomposes at approx 280 °C|Hydroxyl radical reaction rate constant = 2.09X10-11 cu cm/molec-sec at 25 °C (est)

    Air and Water Reactions:

    Sensitive to moisture. Water insoluble.

    Reactive Group:

    Acids, Carboxylic

    Reactivity Profile:

    5-AMINOSALICYLIC ACID is incompatible with acids, acid chlorides, acid anhydrides, chloroformates and strong oxidizers. (NTP, 1992)

    Hazard Identification

    Classification of the substance or mixture

    Skin irritation, Category 2

    Skin sensitization, Category 1

    Eye irritation, Category 2

    Specific target organ toxicity – single exposure, Category 3

    GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Warning

    Hazard statement(s)

    H315 Causes skin irritation

    H317 May cause an allergic skin reaction

    H319 Causes serious eye irritation

    H335 May cause respiratory irritation

    Precautionary statement(s)
    Prevention

    P264 Wash ... thoroughly after handling.

    P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

    P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

    P272 Contaminated work clothing should not be allowed out of the workplace.

    P271 Use only outdoors or in a well-ventilated area.

    Response

    P302+P352 IF ON SKIN: Wash with plenty of water/...

    P321 Specific treatment (see ... on this label).

    P332+P317 If skin irritation occurs: Get medical help.

    P362+P364 Take off contaminated clothing and wash it before reuse.

    P333+P317 If skin irritation or rash occurs: Get medical help.

    P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

    P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

    P319 Get medical help if you feel unwell.

    Storage

    P403+P233 Store in a well-ventilated place. Keep container tightly closed.

    P405 Store locked up.

    Disposal

    P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Commercially available oral mesalamine delayed-release tablets should be stored at a controlled room temperature of 20-25 deg C, while the commercially available oral extended-release capsules should be stored at 25 deg C but may be exposed to temperatures ranging from 15-30 deg C.

  • Seller Information
    Business Type:

    Manufactory

    Main Products:

    Semaglutide,Tirzepatide,API,Vitamins,Food Additive

    Location:

    No. 4C-11-A392, Financial Port, Northwest corner of Fengjing Avenue and Fengxin Road, Fengdong New City, Xi 'an, Shaanxi Province

    Payment Terms:

    TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

    Average lead Time:

    5

    Total Annual Revenue:

    $5 million-$10 million

    Total Employees:

    11-50

    Year of Establishment:

    2019

    Shaanxi TNJONE Pharmaceutical Technology Co., LTD., located in the beautiful ancient capital Xi 'an, is committed to the peptide industry, pharmaceutical raw materials, food and feed additives, veterinary drugs and other fields, the enterprise adhering to provide customers with quality service, supply high-quality products, "world peace and health" as its responsibility, the company adhering to the "meet all customer requirements for products" as the service concept, Guarantee "provide qualified products" as the service principle, so that you get "God-like" noble shopping enjoyment. Our company has more than 1000 kinds of polypeptides, raw materials inventory, at any time to meet the various needs of customers for products. Is your best partner.
  • Inquiry History
    3 Inquiries
    Country Product Purchase Quantity Date Posted
    India

    Mesalazine cas 89-57-6 5-aminosalicylic acid USP42 EP8.6

    5 MT Aug 24, 2023
    United States

    5-aminosalicylic acid

    1 KG Apr 17, 2025
    United Kingdom

    5-Aminosalicylic acid 98% solid

    40 G May 8, 2026
    Post an enquiry for this product
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