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Manufacturer Supply High Purity Bibw 2992 CAS 439081-18-2 99% Afatinib Powder buy - image1

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Manufacturer Supply High Purity Bibw 2992 CAS 439081-18-2 99% Afatinib Powder buy - image4

Manufacturer Supply High Purity Bibw 2992 CAS 439081-18-2 99% Afatinib Powder

Name: Manufacturer Supply High Purity Bibw 2992 CAS 439081-18-2 99% Afatinib Powder
Brand: TNJONE
SKU: pr2408151029
Price: 30 USD
Availability: InStock

Unit Price: Get Latest Price 

CAS No.:

439081-18-2

Grade:

Pharmaceutical Grade

Content:

98%

Port:

china any port

Brand:

TNJONE

Packaging:

1kg ,25kg or according to customer's detail requirement.

Price valid (until):

2025-12-30

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Shaanxi TNJONE Pharmaceutical Co., Ltd

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Semaglutide,Tirzepatide,API,Vitamins,Food Additive

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Product Description
Seller Information

Description

Manufacturer Supply High Purity Bibw 2992 CAS 439081-18-2 99% Afatinib Powder

What is Bibw 2992/Afatinib ?

Afatinib is the first approved irreversible ErbB family blocker. the ErbB receptor family consists of four members: EGFR (ErbB1), HER2 (ErbB2), ErbB3 and ErbB4. members of the ErbB family interoperate with other ErbB family members in signaling, and abnormal ErbB family signaling is a key driver of cancer cell growth and proliferation . Afatinib has two targets, EGFR and HER2, which can irreversibly block the abnormalities of intracellular information transmission stimulated by the mutation of epidermal grow th fac tor receptor (EGFR) and the over-expression of human epidermal receptor 2 (HER2) tyrosine kinase, and permanently shut down the signaling channels on which cancer cells depend,

Items	Specifications
Product Name	Bibw 2992/Afatinib
CAS No.	439081-18-2
Appearance	white Powder
Assay	98%
MF	C24H25ClFN5O3
MW	485.94
Melting Point	676.9±55.0 °C(Predicted)
Density	1.380

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Certification

Technical Date Sheet:

Item	Requirements	Test Results
Description	Off-white powder	Off-white powder
Identification	HPLC ,NMR	Complies
Residue on Ignition	≤0.10%	0.05%
Loss on Drying	≤0.50%	0.15%
Heavy Metal	≤20ppm	<20ppm
Purity(HPLC)	≥99.0%	99.99%
Conclusion	It complies with EnterpriseStandard

Application

Estradiol valerate is the valerate of natural estradiol, which has the pharmacological effect of estrogen, can promote and regulate the normal development of female genital ducts and side 1. BIBW2992 (Afatinib, Tomtovok, Tovok) irreversibly inhibits EGFR/HER2 including EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively.
2. Afatinib is an aminocrotonylamino-substituted quinazoline derivative used for the treatment of cancers and diseases of the respiratory tract, lung, gastrointestinal tract, bile duct and gallbladder.
3. Afatinib is the first FDA-approved indication for afatinib was for the first-line treatment of patients with EGFR-mutated metastatic non-small cell lung cancer (NSCLC).

Company Information

Shaanxi TNJONE Pharmaceutical Technology Co., LTD., located in the beautiful ancient capital of Xi 'an, is committed to pharmaceutical raw materials, kill varieties, food and feed additives, chemical reagents, plant extracts and other fields, the enterprise adhering to provide customers with quality service, supply high-quality products. Our company after careful planning, hard study, gradually formed a complete service system, based on the domestic and foreign raw materials market special development. Make the raw materials industry bigger and stronger, and serve the vast number of new and old customers. With "world peace and health" as its responsibility, the company adheres to the service concept of "meeting all requirements of customers for products", and guarantees the service principle of "providing qualified products", so that you can get the "God-like" noble shopping enjoyment. Our company has more than 500 kinds of raw materials inventory at any time to meet the various needs of customers for products. The company's products all comply with the relevant national regulations, from the smallest packaging to tons of goods are available. Is your choice of raw materials the best partner.

Shaanxi TNJONE Pharmaceutical Technology Co., Ltd. is willing to rely on the rapid development of e-commerce and national policy support of the good environment background, nesting, welcome people from all walks of life to visit our company, exchange, and seek common development, looking forward to sharing with you, win-win, to realize the dream.

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FAQ

1.How to get in touch with us?

You can chat with us by Trademanager,WhatsApp or simply giving us an email, a phone call. All our contacts information can be found from our website.

2.Are you a manufacturer or trade company?

We are a professional manufacturer.

3.Can I get a sample?

Yes, free sample can be provided, but shipping cost is covered by your side.

4.What's your MOQ?

It is based on the different product. Some are 1g while some are 1 kg. Please be free to consult our salesman.

5.When can I get the quotation?
We usually quote within 1 hours after we get your inquiry. If it's a urgent order you can call us or mention it in your email subject, and we can take it as priority.

6.Is there any discount?
Yes, some products are applied for discount, but it depends on the quantity.

7.Can you do OEM for me?
Yes,we accept OEM orders, just contact us and give us your requirement. We will offer you a reasonable price and make samples ASAP.

Basic Info

Product Name:

N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide

Other Name:

2-Butenamide,N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-;N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide;915958-11-1

CAS No.:

439081-18-2

Molecular Formula:

C24H25ClFN5O3

InChIKeys:

InChIKey=ULXXDDBFHOBEHA-INIZCTEOSA-N

Molecular Weight:

485.944

Exact Mass:

485.94

HScode:

2934999090

Categories:

Other Chemical Drugs

Characteristics

PSA:

88.6

XLogP3:

3.59

Density:

1.380

Melting Point:

100 - 102 °C

Boiling Point:

676.9±55.0 °C at 760 mmHg

Flash Point:

363.2±31.5 °C

Refractive Index:

1.668

See More N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide Properties 

Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Semaglutide,Tirzepatide,API,Vitamins,Food Additive

Location:
No. 4C-11-A392, Financial Port, Northwest corner of Fengjing Avenue and Fengxin Road, Fengdong New City, Xi 'an, Shaanxi Province

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
5

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2019

Shaanxi TNJONE Pharmaceutical Technology Co., LTD., located in the beautiful ancient capital Xi 'an, is committed to the peptide industry, pharmaceutical raw materials, food and feed additives, veterinary drugs and other fields, the enterprise adhering to provide customers with quality service, supply high-quality products, "world peace and health" as its responsibility, the company adhering to the "meet all customer requirements for products" as the service concept, Guarantee "provide qualified products" as the service principle, so that you get "God-like" noble shopping enjoyment. Our company has more than 1000 kinds of polypeptides, raw materials inventory, at any time to meet the various needs of customers for products. Is your best partner.
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