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Bulk/ Wholesale Antineoplastic Drug Methotrexate Powder CAS no 59-05-2

Name: Bulk/ Wholesale Antineoplastic Drug Methotrexate Powder CAS no 59-05-2
Brand: QSC=Qingdao Baishiwei Chemical
SKU: pr2408202043
Price: 3.09 USD
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CAS No.:

59-05-2

Grade:

Pesticide Grade

Content:

99%

Port:

QINGDAO

Brand:

QSC=Qingdao Baishiwei Chemical

Packaging:

25kg drum

Price valid (until):

2025-01-24

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bestway (Shandong) Chemical Co., LTD

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Location:

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Product Description
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Inquiry History

Description

Shop Bulk/ Wholesale Antineoplastic Drug Methotrexate Powder CAS no 59-05-2-Detailed Image 1

Methotrexate is an anti-folate anti-metabolite drug with a strong immunosuppressive effect. It is the earliest anti-folate agent that has been successfully used in clinical practice. It is not only effective against leukemia, but also has good curative effect on solid tumors. It is a basic clinical anti-folate agent. One of the cancer drugs. Methotrexate can selectively act on proliferating cells and prevent immune blast cells from dividing and proliferating. It has inhibitory effects on both humoral immunity and cellular immunity, and also has strong anti-inflammatory effects. It has inhibitory effects on primary immune responses and secondary immune responses, delayed allergic reactions, and transplantation versus host reactions.

Items	Standard		Test Results
Identification	A.H-NMR:Comply with the structure		Complies
	B.LC-MS:Comply with the structure		Complies
	C.The IR spectrum of sample should be identical with that of reference standard.		Complies
	D.HPLC-ESI-MS The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay.		Complies
Loss on drying %	≤2.0		0.19
Heavy metals ppm	≤10		<10
Moisture %	≤1.0		0.1
Sulphated ash %	≤0.5 determined on 1.0 g.		0.009
Residue on ignition %	≤0.1		0.03
Related Substances %	Unspecified impurities: for each impurity	≤0.10	<0.10
Related Substances %	Total Impurity	≤0.5	0.18
Purity %	≥99.0		99.7
Assay %	99.0 ~101.0 (anhydrous substance).		99.8
Storage	Preserve in well-closed, light-resistant and airtight containers.		Complies

Product Description
Methotrexate is a cell cycle arresting agent with varying effects. Methotrexate arrests the cell cycle in late G1/S-phase, therefore inhibiting the synthesis of DNA, RNA, thymidylates, and proteins. In the previous cases the inhibition of enzymes involved in purine metabolism, leading to accumulation of adenosine, or the suppression of intercellular adhesion molecule expression by T cells as the main mechanism of action by methotrexate. The compound has been observed to irreversibly inhibit dihydrofolate reductase (DHFR) and thymidylate synthetase (TS). Methotrexate has been shown to modulate inflammation by promoting adenosine release or inhibiting transmethylation reactions. In adherent splenic cells, IL-1 production was decreased by methorexate.

Function

1.It is used to treat cancer, autoimmune diseases, ectopic pregnancy, and for medical abortions.
2.It is used for include breast cancer, leukemia, lung cancer, lymphoma, and osteosarcoma.Types of autoimmune diseases
3.It is used for include psoriasis, rheumatoid arthritis, and Crohn's disease.

Application

Methotrexate is used as a disease-modifying treatment for some autoimmune diseases, including rheumatoid arthritis, juvenile dermatomyositis, psoriasis, psoriatic arthritis, lupus, sarcoidosis, Crohn's disease (although a recent review has raised the point that it is fairly underused in Crohn's disease), eczema and many forms of vasculitis. Although originally designed as a chemotherapy drug (using high doses), in low doses, methotrexate is a generally safe and well tolerated drug in the treatment of certain autoimmune diseases.

Because of its effectiveness, low-dose methotrexate is now first-line therapy for the treatment of rheumatoid arthritis. Weekly doses are beneficial for 12 to 52 weeks duration therapy, although discontinuation rates are as high as 16% due to adverse effects. Although methotrexate for autoimmune diseases is taken in lower doses than it is for cancer, side effects such as hair loss, nausea, headaches, and skin pigmentation are still common. Use of low doses of methotrexate together with NSAIDS such as aspirin or paracetamol is relatively safe in people being treated for rheumatoid arthritis, if adequate monitoring is done.

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1.High quality and competitive price.
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4.We will inform you all the information at every stage in advance.
5.Packaging can gear to buyers’ special request.

Our service

1. Reply your inquiry in 24 working hours.
2. Customized design is available. OEM are welcomed.
3. Exclusive and unique solution can be provided to our customer by our well-trained and professional engineers and
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4. As an honest seller, we always use superior raw material, advanced machines, skilled technicians to ensure our products to be finished in high quality and stable feature.

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1. High-concentration products, strictly control the quality.
2. Reasonable and flexible price matched with high quality.
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5. Safe raw materials from China.
6. Have professional customs clearance capabilities and the best after-sales service.

Shop Raw Materials Chemical China Supplier Price Pure Telmisartan Powder 144701-48-4-Detailed Image 4

Basic Info

Product Name:

Methotrexate

Other Name:

METHOTREXATEFORINJECTION;sodium 4-[[4-[(2,4-diaminopteridin-6-yl)methyl-methyl-amino]benzoyl]am ino]-5-hydroxy-5-oxo-pentanoate;METHOTREXATE(N-(4-(((2,4-DIAMINO-6-PTERIDINYL)METHYLAMINO)BENZOYL)-L-GLUTAMICACID);4-Amino-N10-methylfolic acid;Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, L-(+)- (8CI);L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]- (9CI);L-Methotrexate;Methotrexat-Ebewe

CAS No.:

59-05-2

Molecular Formula:

C20H22N8O5

InChIKeys:

FBOZXECLQNJBKD-ZDUSSCGKSA-N

Molecular Weight:

454.44

Exact Mass:

454.44

BRN:

70669

EC Number:

200-413-8

UNII:

YL5FZ2Y5U1

NSC Number:

740

UN Number:

3249

TSCA:

TSCA listed

DSSTox ID:

DTXSID4020822

NCI Thesaurus Code:

C642

Color/Form:

Light yellow to yellow

ATC Code:

L04AX03|L01BA01|L - Antineoplastic and immunomodulating agents

HScode:

29335995

Categories:

Inhibitors

Characteristics

PSA:

211

XLogP3:

-1.8

Appearance:

powder

Density:

1.4080 (rough estimate)

Melting Point:

195°C

Boiling Point:

561.26°C (rough estimate)

Flash Point:

11℃

Refractive Index:

1.6910 (estimate)

Water Solubility:

Insoluble. <0.1 g/100 mL at 19 ºC

Storage Conditions:

−20°C

Vapor Pressure:

2.1X10-19 mm Hg at 25 deg C /Estimated/

Toxicity:

LD50 oral in rat: 135mg/kg

Specific rotation:

Specific optical rotation: 20.4 + or - 0.6 deg at 21 °C/589 D (concentration by 0.1 N sodium hydroxide) maximum absorption: 243nm, A1= 388;307 nm, A1 = 475 (in 0.1 n hydrogen chloride). 258 nm, A1= 544; 303 nm, A1= 546; 372 nm, A1= 177 (in 0.1 N sodium hydroxide)

PKA:

pKa 3.04/4.99(H2O,t =25,I=0.0025) (Uncertain)

Henrys Law Constant:

Henry's Law constant = 1.5X10-31 atm-cu m/mol at 25 °C /Estimated/

Dissociation Constants:

4.7|pKa = 4.70 (carboxylic acid)|pKa = 3.5 carboxylic acid; pKa2 = 8.8, pKa3 = 9.2 (amines) /Estimated/

Collision Cross Section:

196.2 Å² [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)]|194.8 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Experimental Properties:

Yellow crystals from dilute hydrogen chloride; decomp 185-204 °C (bath preheated to 160 °C). Max absorption (0.1 n hydrogen chloride): 244, 307 nm; max absorption (0.1 N sodium hydroxide): 257, 302, 370 nm; soluble in alkaline solns with decomposition /Methotrexate monohydrate/|Yellow powder; soluble in water. /Methotrexate sodium/|Hydroxyl radical reaction rate constant = 3.2X10-10 cu cm/molec-sec at 25 °C /Estimated/

Air and Water Reactions:

Methotrexate is sensitive to hydrolysis, oxidation and light. Insoluble in water.

Reactive Group:

Acids, Carboxylic

Reactivity Profile:

Methotrexate decomposes in very acidic or alkaline conditions. Methotrexate is incompatible with strong oxidizing agents and strong acids.

Critical Temperature & Pressure:

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

See More Methotrexate Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 3, Oral

Skin irritation, Category 2

Eye irritation, Category 2

Reproductive toxicity, Category 1B

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H301 Toxic if swallowed H315 Causes skin irritation H319 Causes serious eye irritation H360 May damage fertility or the unborn child
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P203 Obtain, read and follow all safety instructions before use.
Response	P301+P316 IF SWALLOWED: Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P318 IF exposed or concerned, get medical advice.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Methotrexate sodium tablets should be protected from light and stored in well-closed containers at 15-30 deg C. Methotrexate sodium injection and powder for injection should be protected from light and stored at 15-30 deg C. Methotrexate sodium

See More Methotrexate Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
ghk cu

Location:
No. 33688 Jingshi East Road, High-tech Zone, Jinan City, Shandong Province, Jinan Comprehensive Bonded Zone Customs supervision warehouse supporting office area 101-B3

Payment Terms:
100% TT in advance

Average lead Time:
120

Total Annual Revenue:
$1 million-$2.5 million

Total Employees:
11-50

Year of Establishment:
2021

Inquiry History

2 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	METHOTREXATE IP/BP/USP	1.00 KG	Jul 4, 2025
India	Methotrexate	1.00 KG	Dec 11, 2023

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