High purity 99% Tesofensine white powder CAS 195875-84-4 for wight loss

Tesofensine More Info

Tesofensine is a novel medication primarily investigated for its potential in treating obesity. It functions as a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI), which means it increases the levels of these three neurotransmitters in the brain, thereby modulating appetite and metabolism

Mechanism of Action

Tesofensine works by inhibiting the reuptake of dopamine, serotonin, and noradrenaline. This inhibition leads to decreased appetite and increased feelings of satiety. Clinical trials have indicated that patients taking tesofensine report significant reductions in hunger and an enhanced sense of fullness, resulting in smaller meal sizes and less frequent snacking

Pharmacokinetics

Tesofensine has a long elimination half-life of approximately 220 hours, allowing for sustained therapeutic effects with once-daily dosing. It is primarily metabolized by the liver enzyme CYP3A4, with minimal renal involvement in its clearance

Clinical Efficacy

In Phase II clinical trials, tesofensine demonstrated substantial weight loss outcomes. For instance, participants taking the highest dose (1 mg) lost an average of 12.6% of their body weight over 24 weeks, compared to a mere 2% loss in those on a placebo. The drug has been shown to not only aid in weight loss but also improve metabolic parameters such as insulin sensitivity and fat oxidation

Safety and Side Effects

While tesofensine has shown promising results, it is not without potential side effects. Commonly reported adverse effects include insomnia, nausea, diarrhea, and an increase in blood pressure at higher doses. Ongoing clinical trials aim to further assess its safety profile and efficacy

Current Status

Originally developed for neurological conditions like Parkinson's and Alzheimer's disease, tesofensine was repurposed for obesity treatment after significant weight loss was noted among trial participants. It is currently undergoing Phase III trials for obesity treatment. The drug's development is being led by Saniona and its partner Medix, with regulatory submissions ongoing in various regions

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