 Home > Encyclopedia > tesofensine

tesofensine

tesofensine structure

CAS No:
195875-84-4
Formula:
C17H23Cl2NO
Chemical Name:
tesofensine
Synonyms:
(1S,3S,4R,5R)-3-(3,4-dichlorophenyl)-4-(ethoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane;(1R,2R,3S,5S)-3-(3,4-Dichlorophenyl)-2-(ethoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane;Tesofensine-13C-d3;8-Azabicyclo[3.2.1]octane, 3-(3,4-dichlorophenyl)-2-(ethoxymethyl)-8-methyl-, (1R,2R,3S,5S)-;Tesofensine 500mcg Tablets;Tesofensine 0.5mg Tablets
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Tesofensine ((1R, 2R, 3S, 5S)-3-(3, 4-dichlorophenyl)-2-(ethoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane)) is an inhibitor of neuronal reuptake of dopamine, noradrenaline, and serotonin. Tesofensine was developed for the treatment of Alzheimer's and Parkinson's disease but lacked efficacy. Meta-analysis revealed that tesofensine (0.125–1.0 mg, once daily; oral) produced dose-dependent weight loss, and 32% of obese patients had ≥ 5% weight loss following 14 wk of treatment. Weight loss was accompanied by hypophagia, suggesting an appetite suppressant action[2].

Tesofensine is a dopamine, serotonin, and noradrenaline (triple) reuptake inhibitor originally developed by NeuroSearch for the treatment of Alzheimer's disease and Parkinson's disease. Development of the compound for these neurological indications was unsuccessful but significant weight loss was reported during the clinical trials in Parkinson's disease. Hence, tesofensine is now being developed by NeuroSearch for the treatment of obesity and type 2 diabetes[1].

tesofensine Basic Attributes

Molecular Weight：

328.28

Exact Mass：

328.28

UNII：

BLH9UKX9V1

Color/Form：

White to off-white

Characteristics

Density：

1.161±0.06 g/cm3(Predicted)

Boiling Point：

396.6±42.0 °C(Predicted)

PKA：

10.46±0.60(Predicted)

Critical Temperature & Pressure：

Store at -20°C

Drug Information

Drug Indication：

Investigated for use/treatment in alzheimer's disease, parkinson's disease, and obesity.

Mechanism of Action：

Tesofensine is a Serotonin-norepinephrine-dopamine-reuptake-inhibitor (SNDRI). SNDRIs are a class of psychoactive antidepressants. They act upon neurotransmitters in the brain, namely, serotonin, norepinephrine and dopamine. These three biogenic monoamines are associated with depression and increasing the availability in the brain is one method used to treat the condition.

MeSH Entry Terms：

(1R-(2-endo,3-exo))-3-(3,4-dichlorophenyl)-2-(ethoxymethyl)-8-methyl-8-azabicyclo(3,2,1)octane-2-hydroxy-1,2,3-propanetricarboxylate

tesofensine Use and Manufacturing

Tesofensine, is a serotonin–noradrenaline–dopamine reuptake inhibitor from the phenyltropane family of drugs, which is currently in clinical development for the treatment of obesity.

Recommended Suppliers of tesofensine

Jinan Million Pharmaceutical Co., Ltd Contact Supplier

CN
2 YRS

Business licensed Certified factory

Manufactory Supplier of Avanafil,Tirzepatide,Semaglutide,Pregabalin,Nootropics,MT2,GPC,supplements

Tesofensine 500mcg high quality supply

CAS No.: 195875-84-4

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Hangzhou Hyper Chemicals Limited Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Best Quality 99.5% API Tesofensine CAS: 195875-84-4 for Weight Loss; Tesofensine citrate

Unit Price: $130-150 /G FOB

CAS No.: 195875-84-4

Grade: Pharmaceutical Grade

Content: 99.5%

Inquiry
DZ CHEMICAL (ZHENGZHOU) CO., LTD. Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of pharmaceutial intermediate

Factory supply Tesofensine powder CAS 195875-84-4

CAS No.: 195875-84-4

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Shanxi QYC Biotechnology Co., LTD Contact Supplier

CN
2 YRS

Business licensed

Trader Supplier of Cosmetic raw material

Factory Wholesale Best Quality 99% Tesofensine CAS: 195875-84-4 for Weight Loss

CAS No.: 195875-84-4

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Reta-peptide Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of Peptides,Tirzepatide,Semaglutide,Retatrutide,MT2,Adipotide,Tesamorelin,MOTS-c,5-amino-1mq,Botulinum toxin

99% powerful weight loss supplement Tesofensine powder tablet and raw powder

CAS No.: 195875-84-4

Grade: Pharmaceutical Grade

Content: 99%

Inquiry