High Quality EP Standard Troxerutin CAS 7085-55-4 with good price and fast delivery

Troxerutin More Info

Troxerutin is a semi-synthetic bioflavonoid derived from rutin, classified as a hydroxyethylrutoside. It is known for its vasoprotective, antioxidant, anti-inflammatory, and anti-edema properties, and is used primarily in the management of vascular disorders.

Mechanism of Action

Troxerutin exerts its effects through multiple mechanisms:
Antioxidant activity: Increases antioxidant enzymes (such as SOD and GPx), reduces oxidative damage, and enhances nuclear translocation of Nrf2, a key regulator of the antioxidant response.
Anti-inflammatory effects: Suppresses the release of pro-inflammatory cytokines, reduces migration of inflammatory cells, and downregulates the NF-κB pathway.
Anti-apoptotic effects: Decreases pro-apoptotic proteins (APAF-1, BAX, caspases-9 and -3) and increases anti-apoptotic BCL-2.
Vascular protection: Strengthens blood vessel walls, reduces capillary fragility, and improves microcirculation.
Modulation of VEGF and PKCβII/HuR pathway: Reduces hyperglycemia-induced VEGF expression and neovascularization, relevant in diabetic retinopathy.

Applications

Chronic venous insufficiency: Used to manage symptoms such as leg swelling, pain, and varicose veins due to poor venous return.
Capillary fragility: Recommended for conditions involving easy bruising and fragile capillaries.
Hemorrhoids (piles): Promotes healing, reduces pain, swelling, and irritation by improving blood flow and preventing clotting.
Diabetic retinopathy: Shown to counteract hyperglycemia-induced VEGF production and neovascularization, suggesting a preventive role in early diabetic retinopathy.
Other potential uses: Neuroprotective, nephroprotective, antihyperlipidemic, and cardioprotective effects have been reported in experimental models.

Routes of Administration

Oral: Capsules or tablets, typically taken with or without food at a fixed time daily.
Topical: Creams or gels applied to affected areas for conditions like varicose veins or hemorrhoids.
Parenteral: Intramuscular injections have been used in clinical trials for acute hemorrhoids.

Safety and Side Effects

Common side effects: Nausea, diarrhea, skin rash, headache, vertigo, indigestion, and gastrointestinal discomfort.
Allergic reactions: Rash, itching, and rare hypersensitivity reactions; contraindicated in individuals with known hypersensitivity to troxerutin.
Precautions: Not recommended for use in children or during pregnancy/breastfeeding unless advised by a healthcare professional; caution in patients with active bleeding disorders or on anticoagulants due to possible increased bleeding risk.
Serious side effects: Rare; most adverse reactions are mild and transient.

Pharmacokinetics

Absorption: Oral absorption is relatively low (~10%); absorption may be influenced by food and other substances.
Distribution: High affinity for blood vessel walls, distributed throughout the body via the bloodstream.
Metabolism: Undergoes hepatic metabolism, similar to other flavonoids.
Elimination: Excreted mainly via the bile; caution in hepatic impairment.
Half-life: Approximately 24 hours after oral administration, supporting once-daily dosing.

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FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

T/T in advance
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Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
FedEx  UPS  DHL  EMS                               
Fast: 3-7 days around, high cost, door to door service

By Air                                        
Suitable for more than 50kg 
Fast: 3-7 days, hight cost, port to port, professional broker needed 

By Sea
Suitable for more than 500kg      
Fast: 7-45 days, low cost, port to port, professional broker needed 

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.