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2-PMPA 98%

Name: 2-PMPA 98%
Brand: Didue
SKU: pr2409221005
Price: 1 USD
Availability: InStock

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CAS No.:

173039-10-6

Grade:

Pharmaceutical Grade

Content:

98%

Port:

Shanghai

Brand:

Didue

Packaging:

Price valid (until):

2024-10-22

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Shaanxi Dideu Medichem Co. Ltd

Company Type:

Manufactory

Location:

China

Payment Terms:

TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average Lead Time:

7 days

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Main Products:

Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst

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2-PMPAisapotentandselectiveinhibitorofGCPII,anenzymewhichcatabolizestheabundantneuropeptideN-acetyl-aspartyl-glutamate(NAAG)toN-acetylaspartate(NAA)andglutamate.2-PMPAdemonstratesrobustefficacyinnumerousanimalmodelsofneurologicaldiseaseChemicalbook.2-PMPAisahighlypolarcompoundwithmultiplenegativechargescausingsignificantchallengesforanalysisinbiologicalmatrices.2-PMPAreducesketamine-induceddecreaseofcellviabilityandincreaseofLDHlevelsinthemixedculturesbutnotintheneuronalcultures.

Intraperitonealadministrationof100mg/kg2-PMPAresultsinmaximumconcentrationinplasmaof275μg/mLat0.25h.Thehalf-life,areaunderthecurve,apparentclearance,andvolumeofdistributionare0.64h,210μg×h/mL,7.93mL/min/kg,and0.44L/kg,respectively.2-PMPAat250mg/kg,inananesthetizedmouse,afteraninitialrise,producesarapiddeclineandastrikingattenuationinBOLDsignalsingraymatter.Thesignatureof2-PMPAonbrainT2*signalsingraymatteratboth167and250mg/kgincludesasignificantinitialChemicalbookriselastingseveralminutes.2-PMPAhasneuroprotectiveactivityinananimalmodelofstrokeandanti-allodynicactivityinCCImodel.Administrationof2-PMPA(50mg/kg)producesameanpeakconcentrationof2-PMPAof29.66±8.1μM.Thisconcentrationisabout100,000foldmorethanisneededforinhibitionofNAAGpeptidase,andindicatesverygoodpenetrationtothebrain.Administrationof50mg/kg2-PMPA(i.p.)producesacontinuouslyincreasingextracellularNAAGconcentration,whichstartesdirectlyafterapplication.

Items	Specifications
Target point	IC50: 300 pM (GCPII)
Biological activity	2-PMPA is a highly selective glutamate carboxypeptidase II (GCPII) inhibitor with an IC50 value of 300 pM

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Basic Info

Product Name:

2-(Phosphonomethyl)pentanedioic acid

Other Name:

Pentanedioic acid,2-(phosphonomethyl)-;2-(Phosphonomethyl)pentanedioic acid

CAS No.:

173039-10-6

Molecular Formula:

C6H11O7P

InChIKeys:

InChIKey=ISEYJGQFXSTPMQ-UHFFFAOYSA-N

Molecular Weight:

226.12

Exact Mass:

226.12

DSSTox ID:

DTXSID90436036

Categories:

Inhibitors

Characteristics

Density:

1.658±0.06 g/cm3

Boiling Point:

538.8±60.0 °C(Predicted)

PKA:

2.06±0.10

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Seller Information

Business Type:
Manufactory

Main Products:
Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst

Location:
https://www.dideu.com/en/

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
7 days

Total Annual Revenue:
Above $100 million

Total Employees:
Above 1000

Year of Establishment:
2016

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2-PMPA 98%

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