Wholesale Price Supply High Quarity Alphacalcidol CAS 41294-56-8 Vitamins

Product Details

Alfacalcidol

At present, there are mainly tablets and capsules of alfacalcidol on the domestic market. Alfacalcidol is an ideal active vitamin D derivative preparation currently developed. It has a strong affinity with vitamin D-binding proteins and is active in the liver. Active 1α, 25-(OH)2D3 is formed after the action of liver microsomal hydroxylase, which is distributed in target tissues such as intestines and bones and binds to receptors to promote intestinal calcium absorption, promote bone formation, and inhibit Metabolic regulatory effects such as excess secretion of parathyroid hormone (PTH).
After oral administration, alphacalciferol is rapidly absorbed from the intestine into the blood, and the 25-hydroxyl group of the side chain is combined by the action of liver microsomal 25-hydroxylase to generate active 1α, 25-(OH)2D3, which is distributed in the intestine. And in target tissues such as bone, it can promote intestinal calcium absorption when combined with receptors, and has a series of physiological activities such as bone salt dissolution and bone formation. Rats lacking vitamin D and kidney-removed rats were given this product for experiments. It can be seen that it promotes intestinal absorption of calcium and increases serum calcium levels. In rats whose kidneys have been removed, most of the bone resorption cavities, osteoid layers, and low-calcification layers have increased due to complete kidney removal. After being given this product for 30 days for experiments, bone regeneration can be seen. Therefore, alfacalcidol has the effect of promoting bone formation. For patients with senile osteoporosis, iliac bone biopsies were performed before and after administration of this product using electron and optical microscopes. It was found that active osteoblasts, osteocytes, and calcified bone cavities increased, and bone histological improvement was achieved.
Alfacalcidol can be used to improve various symptoms caused by abnormal vitamin D metabolism in chronic renal insufficiency, hypoparathyroidism, vitamin D-dependent rickets, and osteomalacia, such as hypocalcemia, tetany, and bone pain. , bone lesions and osteoporosis.

Company Introduction

XINKAIYUE is mainly engaged in the export of fine chemicals, cosmetic raw materials, food additives, pharmaceutical intermediates and other products,  which are widely used in medicine, health products, cosmetics, nutritional supplements, food additives and other fields.
Our company has its own research and development team and production plant. Our company is dedicated to the development of  international markets. Our products are mainly exported to many countries and regions,
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In addition，we have professional and experienced engineers and scientists, providing new polypeptide drug biosynthesis solutions, which help partners stay  ahead of the polypeptide drug discovery, clinical development and market production.

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