HOE-140 Cas 138614-30-9 Peptides Raw Powder Factory Supply wholesale price

Product Details

HOE-140

Biological activity
Icatibant Acetate is an antagonist of the bradykinin B2 receptor and can be used to treat hereditary angioedema.
In vitro study
Icatibant(10-30μM) potentiates angiotensin III, but not angiotensin II (contraction mediated by angiotensin AT1 receptors), and Lys-des-Arg9-bradykinin, but not des-Arg9-bradykinin (effects mediated by the bradykinin B1 receptors).
In vivo study
Icatibant(10-30μM) potentiates angiotensin III, but not angiotensin II (contraction mediated by angiotensin AT1 receptors), and Lys-des-Arg9-bradykinin, but not des-Arg9-bradykinin (effects mediated by the bradykinin B1 receptors).
Animal Model:Female mice of the CBA/J(H-2k) strain.
Dosage:0.06,0.3,or1.5mg/kg.
Administration:Subcutaneous administration twice daily.
Result:The The length of the large intestine was 93.6±6.8mm with the 1.5mg/kg dosage and 94.0±4.1mm with the 0.3mg/kg dosage, showing a significant preventive effect on shortening.

Company Introduction

XINKAIYUE is mainly engaged in the export of fine chemicals, cosmetic raw materials, food additives, pharmaceutical intermediates and other products,  which are widely used in medicine, health products, cosmetics, nutritional supplements, food additives and other fields.
Our company has its own research and development team and production plant. Our company is dedicated to the development of  international markets. Our products are mainly exported to many countries and regions,
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In addition，we have professional and experienced engineers and scientists, providing new polypeptide drug biosynthesis solutions, which help partners stay  ahead of the polypeptide drug discovery, clinical development and market production.

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