High Quality Pharmaceutical Raw White Powder Eprinomectin CAS 123997-26-2 for Veterinary Use

Eprinomectin More Info

Eprinomectin is a semi-synthetic derivative of avermectin, primarily used as an anthelmintic agent in veterinary medicine. It is particularly effective against a variety of parasitic infections in livestock. 

Mechanism of Action

Eprinomectin acts by binding to specific glutamate-gated chloride channels and gamma-aminobutyric acid (GABA)-gated chloride channels in the nervous system of invertebrates. This binding leads to:
Increased Chloride Ion Permeability: The binding opens these channels, allowing an influx of chloride ions into the cells, which results in hyperpolarization of the nerve and muscle cells.
Paralysis and Death of Parasites: The hyperpolarization disrupts normal neuromuscular function, leading to paralysis and eventual death of the parasites.
Eprinomectin's selectivity for invertebrate channels over mammalian channels accounts for its safety profile in treated animals.

Applications

Eprinomectin is primarily used in veterinary medicine for:
Anthelmintic Treatment: Effective against a wide range of gastrointestinal nematodes and lungworms in cattle and sheep.
Ectoparasitic Control: Used to treat infestations by external parasites such as mites and lice.
Broad-Spectrum Activity: Eprinomectin is effective against various species of roundworms and some arthropods.

Routes of Administration

Eprinomectin is typically administered through:
Topical Application: Commonly available as a pour-on formulation for cattle and sheep. This method allows for easy application and effective absorption through the skin.
Injectable Forms: Less common but may be used in specific veterinary practices.

Safety and Side Effects

Eprinomectin is generally well tolerated, but potential side effects may include:
Mild Reactions: Some animals may experience transient reactions at the site of administration or mild gastrointestinal disturbances.
Severe Reactions: Although rare, allergic reactions or neurological symptoms may occur if overdosed or improperly administered.
Contraindications: Caution is advised when administering to pregnant or lactating animals, as well as those with known hypersensitivity to the drug.

Pharmacokinetics

The pharmacokinetics of eprinomectin involve several key aspects:
Absorption: Eprinomectin is well absorbed when applied topically. The pour-on formulation allows for systemic circulation through the skin.
Distribution: After administration, it distributes widely throughout body tissues. Eprinomectin has a long half-life, allowing for prolonged activity against parasites.
Metabolism: The drug undergoes hepatic metabolism, although specific metabolic pathways are not fully characterized.
Elimination Half-Life: Studies indicate that eprinomectin has an elimination half-life ranging from approximately 6.4 days after topical application.
Excretion: Eprinomectin is primarily excreted through feces, with minimal renal excretion.

Package Image

FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

T/T in advance
LC at sight
DP at sight

Bank transfer

PayPal

Bitcoin...

Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
FedEx  UPS  DHL  EMS                               
Fast: 3-7 days around, high cost, door to door service

By Air                                        
Suitable for more than 50kg 
Fast: 3-7 days, hight cost, port to port, professional broker needed 

By Sea
Suitable for more than 500kg      
Fast: 7-45 days, low cost, port to port, professional broker needed 

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.