Supply High Purity GB-115 CAS 678996-63-9 | Anxiolytic Peptide Compound for Neuroscience Research

GB-115 More Info

GB-115 is a novel synthetic dipeptide compound developed at the V.V. Zakusov Research Institute of Pharmacology, designed as a selective anxiolytic agent within a broader program of peptide-based drug design. Its chemical designation is N-(6-phenylhexanoyl)-glycyltryptophan amide (also known as N-(1-oxo-6-phenylhexyl)glycyl-L-tryptophanamide), with the molecular formula C25H30N4O3 and a molecular weight of 434.53 g/mol. With the CAS number 678996-63-9, the compound is typically supplied as a high-purity material exceeding 98% for research applications.

The pharmacological mechanism of GB-115 is defined by its action as a central antagonist of cholecystokinin-1 (CCK-1) receptors, a target implicated in the regulation of anxiety and stress responses. This mechanism distinguishes it from traditional benzodiazepine anxiolytics, as it modulates neuropeptide signaling pathways within the central nervous system. Research has positioned GB-115 as a compound of interest for investigating the interface between anxiety disorders and cognitive function, with preclinical studies confirming its anxiolytic activity in rodent models and nonhuman primates.

Preclinical safety evaluations have demonstrated a favorable profile for GB-115. Acute oral administration at maximum doses of 6000 mg/kg in mice and 3500 mg/kg in rats resulted in no fatalities. Chronic administration over six months in rabbits and rats at doses of 0.1 and 10 mg/kg induced no irreversible pathological changes in the organs and systems studied, and the compound exhibited no allergenic, immunotoxic, or mutagenic activity. Additionally, research has identified anti-inflammatory effects in models of ConA- and carrageenan-induced inflammation.

Clinical research has characterized the effects of GB-115 in patients with Generalized Anxiety Disorder (GAD). In a study involving 25 patients treated with a 6 mg/d dose for 21 days, significant improvements were observed across multiple parameters. Hamilton Anxiety Rating Scale (HARS) scores decreased from a median of 22 at baseline to 5 by Day 21, while Multidimensional Fatigue Inventory (MFI-20) scores showed marked reduction. Cognitive assessments revealed increased processing speed, improved attention parameters, and enhanced performance on attention-switching tasks, indicating a consistent cognitive enhancement profile alongside anxiolytic action.

GB-115 represents an example of the "peptide-based drug design" strategy, creating peptide analogs from the structures of known psychotropic agents or active dipeptide sites of neuropeptides. The compound is currently under investigation in clinical trials and is supplied exclusively as a research-use-only material. Material is commonly available in research quantities from grams to bulk packaging, and should be stored in a well-closed container, protected from light, in a cool and dry environment, with recommended storage at -20°C for powder form.

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