High Quality USP White Powder Ketoprofen CAS 22071-15-4 with best price and fast delivery

Ketoprofen More Info

Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) that possesses analgesic, antipyretic, and anti-inflammatory properties. It is primarily used to alleviate pain and inflammation associated with various conditions such as arthritis, dysmenorrhea, and other acute pain scenarios.

Mechanism of Action

Ketoprofen functions by inhibiting the cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2, which are crucial in the biosynthesis of prostaglandins from arachidonic acid. By blocking these enzymes, ketoprofen reduces the production of prostaglandins that mediate pain, inflammation, and fever.

Metabolism

Ketoprofen undergoes hepatic metabolism primarily through:
Glucuronidation: Conjugation with glucuronic acid.
Hydroxylation: Metabolism via CYP3A4 and CYP2C9 enzymes.
Reduction: Conversion of its ketone moiety by carbonyl reducing enzymes

Applications

Ketoprofen is indicated for:
Rheumatoid Arthritis
Osteoarthritis
Dysmenorrhea
Postoperative Pain
Acute Pain Conditions
It may also be utilized for various inflammatory conditions due to its analgesic properties.

Routes of Administration

Ketoprofen is available in various forms:
Oral capsules
Extended-release oral capsules
Topical formulations (gels and patches)
The dosage and form depend on the specific condition being treated and patient needs.

Safety and Side Effects

Common Side Effects
While ketoprofen is effective, it can lead to several side effects:
Gastrointestinal issues (nausea, vomiting, diarrhea)
Headaches
Dizziness
Increased blood pressure
Edema (swelling) in extremities.
Serious Side Effects
Serious adverse reactions may include:
Gastrointestinal Risks: Increased risk of ulcers, bleeding, or perforation in the gastrointestinal tract, especially in older adults or those with a history of ulcers.
Cardiovascular Events: Potential for serious cardiovascular thrombotic events such as heart attack or stroke.
Kidney Damage: Risk of renal impairment or failure with prolonged use.
Severe Allergic Reactions: Including symptoms like swelling of the face or throat and severe skin reactions such as Stevens-Johnson syndrome.

Pharmacokinetics

Absorption and Distribution
Ketoprofen is well absorbed from the gastrointestinal tract. Its bioavailability allows effective therapeutic levels to be achieved quickly after administration.
Elimination
The drug is primarily excreted via urine as unchanged drug and metabolites. The half-life ranges from 1.5 to 2 hours, necessitating multiple doses throughout the day for sustained effects.
Special Considerations
Elderly patients or those with renal impairment may require dose adjustments due to altered pharmacokinetics and increased risk of adverse effects.

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FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

T/T in advance
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Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
FedEx  UPS  DHL  EMS                               
Fast: 3-7 days around, high cost, door to door service

By Air                                        
Suitable for more than 50kg 
Fast: 3-7 days, hight cost, port to port, professional broker needed 

By Sea
Suitable for more than 500kg      
Fast: 7-45 days, low cost, port to port, professional broker needed 

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.