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High Quality 99% Pharmaceutical White Powder Aprepitant CAS 170729-80-3 with best price and fast delivery

Name: High Quality 99% Pharmaceutical White Powder Aprepitant CAS 170729-80-3 with best price and fast delivery
Brand: HyperChem
SKU: pr2501031100
Price: 8 USD
Availability: InStock

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CAS No.:

170729-80-3

Grade:

Pharmaceutical Grade

Content:

99%

Port:

SHANGHAI

Brand:

HyperChem

Packaging:

1kg/Bag, 25kg/drum

Price valid (until):

2025-02-03

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Hangzhou Hyper Chemicals Limited

Company Type:

Trader

Location:

China

Qualification:

Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

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Product Description
Seller Information
Inquiry History

Description

Name	Aprepitant
CAS number	170729-80-3
EINECS number	677-636-6
Synonym	MK0869; MK 0869; MK-0869; ONO7436; ONO-7436; ONO 7436; L754030; L-754030; L 754030; Aprepitant; Emend; 5-(((2R,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one
Description	Aprepitant is a small molecule, high-affinity substance P antagonist (SPA) with antiemetic activity. Crossing the blood brain barrier, aprepitant binds selectively to the human substance P/neurokinin 1 receptor in the central nervous system (CNS), thereby inhibiting receptor binding of endogenous substance P and substance P-induced emesis. This agent has little or no affinity for serotonin type 3 (5-HT3), dopamine, and corticosteroid receptors.
Structure
Molecular Formula	C23H21F7N4O3
Molecular Weight	534.43 g/mol
Appearance	Solid powder
Quality Standard	Enterprise Standard
Assay	≥98%
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Store in cool place. Keep container tightly closed in a dry and well ventilated place.
Shelf Life	>2 years if stored properly
Sample package	Aluminium foil bag
Commercial package	Aluminium Tin, Fiber drum
Origin	China
HS Code	2941902000

Aprepitant More Info

Aprepitant is a neurokinin-1 (NK1) receptor antagonist used primarily as an antiemetic to prevent nausea and vomiting associated with chemotherapy and surgery. It works by blocking the action of substance P, a neuropeptide involved in the vomiting reflex, thereby reducing the likelihood of emesis (vomiting).

Mechanism of Action

Aprepitant selectively binds to and inhibits NK1 receptors located in the central nervous system. By blocking these receptors, it prevents substance P from exerting its effects, which include:
Inhibition of Vomiting Reflex: Aprepitant reduces both acute and delayed phases of nausea and vomiting induced by cytotoxic chemotherapeutic agents like cisplatin.
Enhanced Efficacy with Other Antiemetics: It is often used in combination with other antiemetic medications, such as 5-HT3 receptor antagonists (e.g., ondansetron) and corticosteroids (e.g., dexamethasone), to improve overall antiemetic effects.

Applications

Chemotherapy-Induced Nausea and Vomiting (CINV): Particularly effective in patients undergoing highly emetogenic chemotherapy.
Postoperative Nausea and Vomiting (PONV): Used to prevent nausea and vomiting following surgical procedures.

Routes of Administration

Aprepitant is available in several formulations:
Oral Capsules: Commonly used for outpatient settings.
Intravenous Formulation: Used in hospital settings for immediate effect.

Safety and Side Effects

Common Side Effects
Commonly reported side effects include:
Fatigue
Headaches
Dizziness
Constipation
Nausea
Loss of appetite
Hiccups
Indigestion
Serious Side Effects
Serious adverse reactions can occur, including:
Allergic Reactions: Symptoms may include hives, difficulty breathing, or swelling of the face, lips, tongue, or throat.
Cardiovascular Issues: Such as irregular heartbeats or hypotension.
Severe Skin Reactions: Including skin peeling or blisters.
Neutropenia: Low white blood cell counts may increase infection risk.
Patients are advised to report any severe side effects or unusual symptoms to their healthcare provider immediately.

Pharmacokinetics

Absorption and Distribution
Aprepitant has an oral bioavailability of approximately 60–65%. It reaches peak plasma concentrations within 3 to 4 hours after administration. The volume of distribution is around 70 L, indicating extensive tissue distribution.
Metabolism and Excretion
Aprepitant is primarily metabolized by the liver through cytochrome P450 enzymes, particularly CYP3A4. The drug has a half-life of approximately 9 to 13 hours, allowing for once-daily dosing in most cases. A significant portion of the drug is excreted in urine as metabolites.

Package Image

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FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

T/T in advance
LC at sight
DP at sight

Bank transfer

PayPal

Bitcoin...

Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express
FedEx UPS DHL EMS
Fast: 3-7 days around, high cost, door to door service

By Air
Suitable for more than 50kg
Fast: 3-7 days, hight cost, port to port, professional broker needed

By Sea
Suitable for more than 500kg
Fast: 7-45 days, low cost, port to port, professional broker needed

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders:
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.

Certificates

Basic Info

Product Name:

Aprepitant

Other Name:

3H-1,2,4-Triazol-3-one,5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-;3H-1,2,4-Triazol-3-one,5-[[2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-,[2R-[2α(R*),3α]]-;5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one;L 754030;MK 869;Aprepitant;MK 0869;Emend;ONO 7436;221350-96-5

CAS No.:

170729-80-3

Molecular Formula:

C23H21F7N4O3

InChIKeys:

InChIKey=ATALOFNDEOCMKK-OITMNORJSA-N

Molecular Weight:

534.4266624

Exact Mass:

534.43

EC Number:

1806241-263-5

UNII:

1NF15YR6UY

NSC Number:

748825

DSSTox ID:

DTXSID3049047

NCI Thesaurus Code:

C49173

ATC Code:

A04AD12|A - Alimentary tract and metabolism

HScode:

2934990002

Categories:

Antineoplastic Agents

Characteristics

PSA:

75.2

XLogP3:

4.2

Appearance:

Solid

Density:

1.51±0.1 g/cm3(Predicted)

Melting Point:

255 °C

Refractive Index:

1.564

Water Solubility:

Practically insoluble in water

Storage Conditions:

-20°C Freezer

Specific rotation:

D25 +69° (c = 1.00 in methanol)

See More Aprepitant Properties 

Hazard Identification

Classification of the substance or mixture

Specific target organ toxicity â repeated exposure, Category 2

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H373 May cause damage to organs through prolonged or repeated exposure H410 Very toxic to aquatic life with long lasting effects
Prevention	P260 Do not breathe dust/fume/gas/mist/vapours/spray. P273 Avoid release to the environment.
Response	P319 Get medical help if you feel unwell. P391 Collect spillage.
Storage	none
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Aprepitant Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2013

Certifications:
Certification Report by Bureau Veritas

About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

Our Competitiveness

One-stop supply

Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

Among all the pharmaceuticals,

90% of them with GMP certificates,

85% of them with DMF files and

50% of them passed FDA approval,

30% get CEP certificate

20% are new R&D products.

Custom Repackaging Service

We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

Quality Control/Quality Assurance

HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

Professional

Transparent Communication

Fast Reaction,

Professional Suggestion

Beyond Expectation.

We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.

Inquiry History

1 Inquiries

Country	Product	Purchase Quantity	Date Posted
Pakistan	Aprepitant USP	2.00 KG	Oct 15, 2025

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