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Home > Pharmaceutical Intermediates > Antispasticity Agents > Baclofen for Sale > High Purity 99% Pharmaceutical Raw Powder Baclofen CAS 1134-47-0 with best price and fast delivery
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High Purity 99% Pharmaceutical Raw Powder Baclofen CAS 1134-47-0 with best price and fast delivery

TDS 6 Inquiries

Unit Price: Get Latest Price
CAS No.:

1134-47-0

Grade:

Pharmaceutical Grade

Content:

99%

Port:

SHANGHAI

Brand:

HyperChem

Packaging:

1kg/Bag, 25kg/drum

Price valid (until):

2025-02-03

Company Type:
Trader
Location:
China
Qualification:
Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

  • Product Description

  • Seller Information

  • Inquiry History

  • Description

    Name

    Baclofen

    CAS number

    1134-47-0

    EINECS number

    214-486-9

    Related CAS#

    1134-47-0; 63701-56-4 (S-isomer HCl); 66514-99-6 (S-isomer free base)

    Synonym

    Baclofen; Lioresal, Liofen, Gablofen; Baclon; Kemstro; 4-amino-3-(4-chlorophenyl)butanoic acid

    Description

    Baclofen is a medication primarily used as a muscle relaxant and antispasmodic agent. It functions as a selective agonist at the GABA-B receptor, which is involved in the central nervous system's regulation of muscle tone and spasticity. Baclofen is commonly prescribed for conditions such as multiple sclerosis, spinal cord injuries, and alcohol withdrawal syndrome, where it helps reduce muscle spasms and cramping.

    Structure

    Shop High Purity 99% Pharmaceutical Raw Powder Baclofen CAS 1134-47-0 with best price and fast delivery-Detailed Image 1

    Molecular Formula

    C10H12ClNO2

    Molecular Weight

    213.66 g/mol

    Appearance

    Solid powder

    Quality Standard

    USP Standard

    Assay

    ≥98%

    Shipping Condition

    Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

    Storage Condition

    Store in cool place. Keep container tightly closed in a dry and well ventilated place.

    Shelf Life

    >2 years if stored properly

    Sample package

    Aluminium foil bag

    Commercial package

    Aluminium Tin, Fiber drum

    Origin

    China

    HS Code

    2941902000


    Baclofen More Info

    Baclofen is a muscle relaxant and antispastic agent primarily used to treat muscle spasticity resulting from conditions such as multiple sclerosis, spinal cord injuries, and other neurological disorders. It acts as a selective agonist of the GABA-B receptor, leading to reduced muscle tone and improved motor function.

    Mechanism of Action

    GABA-B Receptor Agonism: Baclofen binds to GABA-B receptors in the central nervous system, which leads to hyperpolarization of neurons. This process decreases the release of excitatory neurotransmitters, effectively inhibiting both monosynaptic and polysynaptic reflexes at the spinal level.
    Reduction of Neurotransmitter Release: By inhibiting excitatory neurotransmitter release, baclofen reduces the excitability of motor neurons, leading to decreased muscle spasticity and relaxation.

    Applications

    Muscle Spasticity: Commonly used in patients with multiple sclerosis or spinal cord injuries.
    Alcohol Use Disorder: Emerging evidence suggests baclofen may help reduce cravings and withdrawal symptoms in individuals with alcohol dependence.
    Neuropathic Pain Management: Sometimes used off-label for managing certain types of neuropathic pain.

    Routes of Administration

    Baclofen is available in several forms:
    Oral Tablets: The most common route for outpatient treatment.
    Intrathecal Baclofen: Administered via an implanted pump for patients requiring high doses or those who cannot tolerate oral baclofen.

    Safety and Side Effects

    Common Side Effects
    Patients taking baclofen may experience:
    Drowsiness
    Dizziness
    Weakness
    Nausea
    Confusion
    Fatigue
    Headaches
    Serious Side Effects
    More severe adverse effects can include:
    Withdrawal Symptoms: Abrupt discontinuation after prolonged use can lead to seizures, hallucinations, and rebound spasticity.
    Respiratory Depression: Particularly concerning in patients with compromised respiratory function.
    Neuropsychiatric Effects: Including confusion, agitation, or worsening of psychiatric disorders.
    Severe Allergic Reactions: Such as rash, itching, or difficulty breathing.

    Pharmacokinetics

    Absorption and Distribution
    Baclofen is well absorbed from the gastrointestinal tract, with peak plasma concentrations typically reached within 1 to 2 hours after oral administration. It has a bioavailability of approximately 30% due to first-pass metabolism.
    Metabolism and Excretion
    The drug is minimally metabolized in the liver and is primarily excreted unchanged in urine. The half-life of baclofen ranges from 3 to 6 hours, depending on individual factors such as renal function.



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    FAQ

    Q1. Can I get a free sample?

    We can send you a samll free sample, and you only need to pay for the shipping cost.


    Q2. What is the HyperChem payment term?

    T/T in advance
    LC at sight
    DP at sight

    Bank transfer

    PayPal

    Bitcoin...


    Q3. What is HyperChem shipment policy?

    Our policy is to strive for the quickest shipment time possible.

    For ready stock samples, they are usually shipped within 3 working days after payment received.
    For non-ready stock, please contact HyperChem sales team to negotiate.


    Q4. What is HyperChem shipment term?

    By Express  
    FedEx  UPS  DHL  EMS                               
    Fast: 3-7 days around, high cost, door to door service

    By Air                                        
    Suitable for more than 50kg 
    Fast: 3-7 days, hight cost, port to port, professional broker needed 

    By Sea
    Suitable for more than 500kg      
    Fast: 7-45 days, low cost, port to port, professional broker needed 


    We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.


    Q5. What HyperChem will provide after shipment?

    For sample orders: 
    After shipment is done, an timely email including:

    1. Track details (Fedex /TNT/DHL/EMS Track number)
    2. Packaging photo
    3. COA, MSDS, etc
    4. Dispatch date & Estimated arriving time
    5. Shipping invoice

    For commercial orders
    A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.



    Company Profile

    Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.


    Among them, our key client industrial sectors around the global are:

    Pharmaceuticals
    Nutrition Ingredients/ Dietary supplements
    Cosmetic Ingredients
    Food Ingredients
    Veterinary API
    Agriculture fertilizer
    Custom Synthesis lab supply


    HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.




    Certificates
    • High Purity 99% Pharmaceutical Raw Powder Baclofen CAS 1134-47-0 with best price and fast delivery Certificates 1

    Basic Info
    Product Name:

    Baclofen

    Other Name:

    Benzenepropanoic acid,β-(aminomethyl)-4-chloro-;Hydrocinnamic acid,β-(aminomethyl)-p-chloro-;β-(Aminomethyl)-4-chlorobenzenepropanoic acid;β-(Aminomethyl)-p-chlorohydrocinnamic acid;β-(4-Chlorophenyl)-γ-aminobutyric acid;Baclofen;Lioresal;Ba 34647;β-(p-Chlorophenyl)-γ-aminobutyric acid;β-p-Chlorophenyl-GABA;CIBA Ba 34647;4-Amino-3-(4-chlorophenyl)butyric acid;C 34647Ba;4-Amino-3-(p-chlorophenyl)butyric acid;DL-4-Amino-3-p-chlorophenylbutanoic acid;dl-Baclofen;(±)-Baclofen;DL-Baclofen;Baclon;4-Amino-3-(4-chlorophenyl)butanoic acid;(±)-4-Amino-3-(4-chlorophenyl)butanoic acid;62594-36-9

    CAS No.:

    1134-47-0

    Molecular Formula:

    C10H12ClNO2

    InChIKeys:

    InChIKey=KPYSYYIEGFHWSV-UHFFFAOYSA-N

    Molecular Weight:

    213.66

    Exact Mass:

    213.66

    EC Number:

    214-486-9

    NSC Number:

    755906|329137

    UN Number:

    2811

    DSSTox ID:

    DTXSID5022641

    ATC Code:

    M03BX01|M - Musculo-skeletal system

    HScode:

    2922492050

    Categories:

    Antispasticity Agents

    Characteristics
    PSA:

    63.3

    XLogP3:

    -1

    Appearance:

    white to very faintly yellow solid

    Density:

    1.2069 (rough estimate)

    Melting Point:

    206-208 °C

    Boiling Point:

    364.3±32.0 °C(Predicted)

    Flash Point:

    174.1±25.1 °C

    Refractive Index:

    1.5500 (estimate)

    Water Solubility:

    soluble in dilute NaOH or dilute HCl. soluble in water at approximately 4mg/ml at pH 7.6;1 M HCl: 50 mg/mL

    Storage Conditions:

    2-8°C

    Toxicity:

    Oral-rat LD50; 145 mg/kg; Oral-Mouse LD50: 200 mg/kg

    Flammability characteristics:

    Flammable; burning produces toxic nitrogen oxides and chloride fumes; patients taking side effects: low blood pressure, reduced pulse, muscle weakness

    PKA:

    9.62+ 0.1 (amino group) and 3.87 + 0.1 (carboxyl group)

    Dissociation Constants:

    9.62 + 0.1 (amino group) and 3.87 + 0.1 (carboxyl group)

    Collision Cross Section:

    149.2 Ų [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)]

    Air and Water Reactions:

    Insoluble in water.

    Reactive Group:

    Acids, Carboxylic

    Reactivity Profile:

    BACLOFEN is an amine. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

    Hazard Identification

    Classification of the substance or mixture

    Acute toxicity - Category 3, Oral

    Skin irritation, Category 2

    Skin sensitization, Category 1

    Eye irritation, Category 2

    Respiratory sensitization, Category 1

    Specific target organ toxicity – single exposure, Category 3

    Reproductive toxicity, Category 1B

    GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Danger

    Hazard statement(s)

    H301 Toxic if swallowed

    H315 Causes skin irritation

    H317 May cause an allergic skin reaction

    H319 Causes serious eye irritation

    H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled

    H335 May cause respiratory irritation

    H360 May damage fertility or the unborn child

    Precautionary statement(s)
    Prevention

    P264 Wash ... thoroughly after handling.

    P270 Do not eat, drink or smoke when using this product.

    P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

    P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

    P272 Contaminated work clothing should not be allowed out of the workplace.

    P284 [In case of inadequate ventilation] wear respiratory protection.

    P271 Use only outdoors or in a well-ventilated area.

    P203 Obtain, read and follow all safety instructions before use.

    Response

    P301+P316 IF SWALLOWED: Get emergency medical help immediately.

    P321 Specific treatment (see ... on this label).

    P330 Rinse mouth.

    P302+P352 IF ON SKIN: Wash with plenty of water/...

    P332+P317 If skin irritation occurs: Get medical help.

    P362+P364 Take off contaminated clothing and wash it before reuse.

    P333+P317 If skin irritation or rash occurs: Get medical help.

    P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

    P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

    P342+P316 If experiencing respiratory symptoms: Get emergency medical help immediately.

    P319 Get medical help if you feel unwell.

    P318 IF exposed or concerned, get medical advice.

    Storage

    P405 Store locked up.

    P403+P233 Store in a well-ventilated place. Keep container tightly closed.

    Disposal

    P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

  • Seller Information
    Business Type:

    Trader

    Main Products:

    Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

    Location:

    Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

    Payment Terms:

    TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

    Average lead Time:

    10

    Total Annual Revenue:

    $5 million-$10 million

    Total Employees:

    11-50

    Year of Establishment:

    2013

    Certifications:

    Certification Report by Bureau Veritas

    About HyperChem

    Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

    Our Competitiveness

    One-stop supply

    Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

    Among all the pharmaceuticals,

    90% of them with GMP certificates,

    85% of them with DMF files and

    50% of them passed FDA approval,

    30% get CEP certificate

    20% are new R&D products.

    Custom Repackaging Service


    We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

    Quality Control/Quality Assurance


    HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

    All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

    Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

    Professional

    Transparent Communication

    Fast Reaction,

    Professional Suggestion

    Beyond Expectation.

    We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.

  • Inquiry History
    6 Inquiries
    Country Product Purchase Quantity Date Posted
    United States

    Baclofen powder

    10 KG Nov 28, 2023
    Netherlands

    Baclofen

    1 KG Nov 26, 2024
    United States

    Baclofen

    1 KG Mar 21, 2024
    Egypt

    Baclofen

    50 KG Sep 18, 2023
    Bangladesh

    Baclofen

    1 KG Sep 9, 2024
    United States

    baclofen

    1 KG Jan 2, 2024
    Post an enquiry for this product
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