High Quality Pharmaceutical Raw Material Clarithromycin CAS 81103-11-9 White Powder

Clarithromycin More Info

Clarithromycin is a macrolide antibiotic used to treat various bacterial infections, including respiratory tract infections, skin infections, and certain gastrointestinal infections. It is effective against a range of Gram-positive and some Gram-negative bacteria. Clarithromycin is often prescribed in situations where patients are allergic to penicillin or when other antibiotics are not suitable.

Mechanism of Action

Clarithromycin works by inhibiting bacterial protein synthesis. Its mechanism involves:
Binding to the 50S Ribosomal Subunit: Specifically, it binds to the 23S rRNA component of the ribosome, blocking the translocation of aminoacyl-tRNA and thus preventing peptide chain elongation during protein synthesis.
Active Metabolite: It is metabolized into 14-hydroxy clarithromycin, which is also active and contributes to its antibacterial effects.
Additionally, clarithromycin inhibits the hepatic enzyme CYP3A4, which can affect the metabolism of various drugs.

Applications

Respiratory Infections: Such as pneumonia, bronchitis, and sinusitis.
Skin and Soft Tissue Infections: Including cellulitis and impetigo.
Helicobacter pylori Eradication: Used in combination with other medications to treat peptic ulcers.
Mycobacterial Infections: Such as Mycobacterium avium complex in immunocompromised patients.
Other Infections: Including cat scratch disease, Lyme disease, and certain types of gastroenteritis.

Routes of Administration

Clarithromycin is available in several formulations:
Oral Tablets and Suspensions: Commonly prescribed for outpatient treatment.
Extended-release Tablets: For once-daily dosing.
It is typically taken with food to enhance absorption and reduce gastrointestinal side effects.

Safety and Side Effects

Common Side Effects
Patients taking clarithromycin may experience:
Nausea
Diarrhea
Abdominal pain
Altered taste sensation
Vomiting
Headache
Serious Side Effects
More severe adverse effects can include:
Liver Toxicity: Symptoms such as jaundice, dark urine, or abdominal pain may indicate liver damage.
QT Prolongation: A heart rhythm disorder that can lead to serious arrhythmias.
Severe Allergic Reactions: Including hives, difficulty breathing, or swelling of the face and throat.
Clostridium difficile Infection: Antibiotic-associated diarrhea that can occur up to two months after treatment.

Pharmacokinetics

Absorption and Distribution
Clarithromycin is well absorbed from the gastrointestinal tract. It has a bioavailability of approximately 50% due to first-pass metabolism. Peak plasma concentrations are reached within 2–3 hours after oral administration.
Metabolism and Excretion
The drug is primarily metabolized in the liver via CYP3A4 and has a half-life of about 3–4 hours. It is excreted mainly in urine as unchanged drug and metabolites.
Special Considerations
Patients with renal impairment may require dosage adjustments due to altered clearance rates.

Package Image

FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

T/T in advance
LC at sight
DP at sight

Bank transfer

PayPal

Bitcoin...

Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
FedEx  UPS  DHL  EMS                               
Fast: 3-7 days around, high cost, door to door service

By Air                                        
Suitable for more than 50kg 
Fast: 3-7 days, hight cost, port to port, professional broker needed 

By Sea
Suitable for more than 500kg      
Fast: 7-45 days, low cost, port to port, professional broker needed 

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.