Dihexa cas no1401708-83-5
GMP ISO 171 Inquiries
1401708-83-5
Pharmaceutical Grade
99.75%
tianjin
Million
1g 10g 100g 1kg/bag 25kg/Cardboard Drum
2054-06-17
Avanafil,Tirzepatide,Semaglutide,Pregabalin,Nootropics,MT2
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Product Description
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial Reference
Dihexa is a synthetic peptide-based compound and angiotensin IV analog. As a research and pharmaceutical raw material, Dihexa is characterized by its defined molecular structure and peptide properties. It is primarily used for research, analytical testing, compound evaluation, and pharmaceutical development.
CertificatesBasic Info-
Product Name:
Dihexa
Other Name:L-Isoleucinamide,N-(1-oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-;N-(1-Oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-L-isoleucinamide;Dihexa;N-Hexanoic-Tyr-Ile-(6)aminohexanoic amide
CAS No.:1401708-83-5
Molecular Formula:C27H44N4O5
InChIKeys:InChIKey=XEUVNVNAVKZSPT-JTJYXVOQSA-N
Molecular Weight:504.7
Exact Mass:504.66
Categories:
Characteristics-
Density:
1.111±0.06 g/cm3(Predicted)
Boiling Point:866.2±65.0 °C(Predicted)
Research-
Class:
Angiotensin IV-derived oligopeptide / HGF-c-Met potentiator
Status:Research compound — Not FDA approved
Mechanism:A synthetic, orally active, blood-brain-barrier-permeable oligopeptide (Hexanoyl-Tyr-Ile-Ahx-NH₂) derived from angiotensin IV. Dihexa binds hepatocyte growth factor (HGF) with high affinity (Kd = 65 pM) and allosterically potentiates HGF activity at its receptor c-Met, promoting dendritic spinogenesis and synaptogenesis. In preclinical models it was reported to be seven orders of magnitude more potent than BDNF at promoting synapse formation. Note: the foundational 2014 paper (McCoy AT, et al. Neurobiol Learn Mem. 2014) was retracted in 2025.
EC50 (HGF Binding KD):65 pM
Activity note:Dihexa is an HGF potentiator, not a direct receptor agonist. It does not activate c-Met alone but markedly augments HGF-induced c-Met activation at low nanomolar HGF concentrations. Functional synaptogenic activity was reported at 10⁻¹°–10⁻⁻ M (original data now subject to retraction).
Source:Original report: McCoy AT, et al. Neurobiol Learn Mem. 2014;115:112-120 (retracted 2025). Benoist CC, et al. J Pharmacol Exp Ther. 2014;351(3):628-637.
Clinical Development:
References-
PubChem:UNII:Literature:
Benoist CC, et al. J Pharmacol Exp Ther. 2014 — HGF/c-Met mechanism; McCoy AT, et al. Neurobiol Learn Mem. 2014 — Synaptogenesis data (Retracted 2025); Athira Pharma: Fosgonimeton (prodrug) pipeline status
Disclaimer:Dihexa is NOT FDA-approved or EMA-approved as a medicine. It is a research compound only. The foundational 2014 paper describing its synaptogenic potency was retracted in 2025. Its phosphate prodrug fosgonimeton failed a Phase 2/3 Alzheimer’s trial (LIFT-AD, 2024). This listing is for industrial and laboratory research use only. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Avanafil,Tirzepatide,Semaglutide,Pregabalin,Nootropics,MT2
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Location:
Room 1-2208, Lianhecaifu Square, No2177, Tianchen Road, Gaoxin District, Jinan City, Shandong Province, China
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Payment Terms:
L/C,100% TT in advance
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Average lead Time:
3
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Total Annual Revenue:
$1 million-$2.5 million
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Total Employees:
11-50
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Year of Establishment:
2012
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Certifications:
business license
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Inquiry History171 Inquiries
Country Product Purchase Quantity Date Posted 
Canada
Dihexa lyophilized 1401708-83-5
1 Aug 23, 2026
Canada
Dihexa 1401708-83-5
1 G Mar 8, 2026 
Bulgaria
Customized peptides high purity Dihexa with fast shipping door to door CAS 1401708-83-5
10 G May 27, 2025 
United States
Dihexa
500 G Aug 19, 2026
United States
Dihexa
25 G Jan 26, 2025 
Russia
DIHEXA
50.00 G Aug 14, 2024 
Hungary
Dihexa
1 G Sep 7, 2026 
Spain
Dihexa
50 MG Aug 28, 2026 
Australia
Dihexa
20 MG Aug 7, 2026 
Belgium
Dihexa
10 G Jul 24, 2026
United States
dihexa
1 G Jul 16, 2026
United States
Dihexa/Acetic Acid 3ml 0.6%
10 PCS Jun 30, 2026 
Philippines
dihexa
10 MG Jun 23, 2026
Philippines
Dihexa 10mg liquid
10 MT Jun 19, 2026
Philippines
Dihexa
50 PCS Jun 4, 2026 
China
Dihexa
1 G May 28, 2026
Australia
dihexa
30 MG May 26, 2026 
Germany
Dihexa
5 G May 4, 2026 
Netherlands
Dihexa
2 G May 1, 2026 
India
Dihexa
1 MT Apr 24, 2026 Post an enquiry for this product
