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Fast shipping, safe delivery, high quality weight loss Peptide Semaglutide 910463-68-2

Semaglutide is the newest GLP-1R agonist and was approved by the FDA as a once-weekly injection for the treatment of T2DM in late 2017. The peptide is chemically similar to liraglutide, with the inclusion of two structural modifications (Lau, Bloch, et al., 2015). The first is the replacement of Gly with the non-proteinogenic amino acid 2-aminoisobutyric acid (Aib) at position 2. The second is the attachment of octadecanoic diacid to the side chain of Lys-26 through a short polyethylene glycol (PEG) spacer and a γ-glutamic acid linker. The amino acid substitution renders the peptide more resistant to DPP-4 compared to liraglutide, and the presence of the 18-carbon fatty acid moiety results in a high binding affinity for serum albumin, which translates to a half-life of approximately 7 days in humans.

Semaglutide---weight loss

Semaglutide has opened a new era of weight management for patients with type 2 diabetes, marking a shift in the treatment model for obesity, and its weight loss effect is close to that of bariatric surgery. In addition to weight loss, the overall health of patients has improved, and their physical function scores, blood pressure, and blood sugar have all been significantly improved.
Introduction
Semaglutide is a new generation of GLP-1 (glucagon-like peptide-1) analogs developed by Novo Nordisk of Denmark. Semaglutide is a long-acting formulation developed based on the basic structure of liraglutide, and its effect in treating type 2 diabetes is better. Novo Nordisk has completed six Phase IIIa studies of semaglutide injection, and has submitted a new drug registration application for semaglutide once-weekly injection to the U.S. Food and Drug Administration (FDA) on December 5, 2016, and also submitted a marketing authorization application (MAA) to the European Medicines Agency (EMA). On the other hand, the once-daily oral formulation of semaglutide is currently in Phase III clinical trials.
Effects
Semaglutide is a long-acting formulation developed based on the basic structure of liraglutide, and its effect in treating type 2 diabetes is better. Semaglutide is prepared by solid-liquid phase synthesis. The linear peptide Aib8, Arg34GLP-1 (7-37) and fatty side chain acylating agent are prepared by solid phase synthesis. The linear peptide Lys26 is modified with the synthetic fatty chain acylating agent under alkaline conditions to obtain semaglutide, and the bioactivity of the homemade samples is determined by time-resolved fluorescence resonance energy transfer immunoassay.

Function

1.Weight loss 
2. Anti-diabetes
3. Alzheimer's disease.

BENEFITS OF GLP-1 Semaglutide

• *Helps slow food leaving your stomach

• *Helps prevent your liver from making too much sugar

• *Helps the pancreas produce more insul when your blood sugar levels are high

• *Can help control blood glucose

• *Can reduce hyperglycemia, especially after meals

• *Can reduce fasting insul and fasting glucose

• *Can reduce hemoglobin A1c

• *Can decrease appetite and caloric intake, while inhibiting weight gain

• *Has been shown to lower triglyceride levels and oxidative stress from high LDL

• *Has been shown to help induce weight loss in obese patients with higher dosing

• *Helps decrease leptin and increase leptin sensitivity

• *Can increase the conversion of white fat to brown fat

 *Facilitates Weight Loss
*Combats Diabetes
*Addresses Alzheimer's Disease

Application

1. Is semaglutide worth it for weight loss?
   In these 68-week trials, semaglutide 2.4 mg was associated with significantly greater weight loss compared to placebo. Semaglutide differs from other GLP-1 receptor agonists by having a longer half-life and producing greater weight loss.
   How much weight can you lose in a week with semaglutide?
   Clinical trials have shown that study participants taking a weekly dose of semaglutide had an average reduction in body weight of 5-10 percent.

   
   

   

   
   

   Peptide Storage Guidelines: General Tips

   When storing peptides, remember to:
   • Store peptide in a cold, dry, dark place
   • Avoid repeated freezing and thawing of peptide
   • Avoid overexposure to the air
   • Avoid light exposure
   • Avoid storing peptides in solution long term
   • Aliquot peptide according to experimental requirements

   
   

   
   

    

   Product parameters  

    

   
   

   Products Name: Semaglutide 
   CAS No.: 910463-68-2
   Purity: >99.0%
   Molecular Formula: C187H291N45O59
   Molecular Weight: 4113.64g/mol
   Sequence: H-His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(C18diacid-γ-Glu-OEG-OEG)]-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH
   Appearance: White Lyophilized powder

   
   

   
   

   Other Names	weight loss slimming Powder
   MOQ	1 box
   Place of Origin	China
   Usage	weight loss & slimming
   Purity	99.99%
   Model Number	JK0662
   Form	powder
   Color	white powder
   Sample	Availiable

Product packaging

5/10/15/20/30mg/vial,10vial/box