Emamectin Benzoate 0.5% +chlorbenzuron 24.5% SC compound pesticide made in China

Emamectin Benzoate 0.5% +chlorbenzuron 24.5% SC compound pesticide made in China

NOMENCLATURE

emamectin benzoate

CAS RN [155569-91-8]; formerly [137512-74-4] and [179607-18-2]  Development codes MK 244 (Merck & Co.)  

emamectin

Common name emamectin (BSI, pa E-ISO, ANSI); emamectine ((f) pa F-ISO)

IUPAC name A mixture containing 90% of (10E,14E,16E,22Z)-(1R,4S,5'S,6S,6'R,8R,12S,13S,20R,21R,24S)-6'-[(S)-sec-butyl]-21,24-dihydroxy-5',11,13,22-tetramethyl-2-oxo-3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6-spiro-2'-(5',6'-dihydro-2'H-pyran)-12-yl 2,6-dideoxy-3-O-methyl-4-O-(2,4,6-trideoxy-3-O-methyl-4-methylamino-a-L-lyxo-hexopyranosyl)-a-L-arabino-hexopyranoside and 10% of (10E,14E,16E,22Z)-(1R,4S,5'S,6S,6'R,8R,12S,13S,20R,21R,24S)-21,24-dihydroxy-6'-isopropyl-5',11,13,22-tetramethyl-2-oxo-3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6-spiro-2'-(5',6'-dihydro-2'H-pyran)-12-yl 2,6-dideoxy-3-O-methyl-4-O-(2,4,6-trideoxy-3-O-methyl-4-methylamino-a-L-lyxo-hexopyranosyl)-a-L-arabino-hexopyranoside  

Chemical Abstracts name (4"R)-5-O-demethyl-4"-deoxy-4"-(methylamino)avermectin A1a + (4"R)-5-O-demethyl-25-de(1-methylpropyl)-4"-deoxy-4"-(methylamino)-25-(1-methylethyl)avermectin A1a (9:1)  

CAS RN [119791-41-2]; formerly [123997-28-4] and [137335-79-6]  

emamectin

Mol. wt. 886.1 (B1a); 872.1 (B1b)  M.f. C49H75NO13 (B1a); C48H73NO13 (B1b)  

COMMERCIALISATION

Production Isolated from fermentation of Streptomyces avermitilis, a naturally occuring soil Actinomycete.  History Discovery and initial development was by Merck & Co., Inc. (now  AG). First sales in Israel and Japan in 1997.  Manufacturers Merck & Co.

APPLICATIONS

emamectin benzoate

Biochemistry Acts by stimulating the release of g-aminobutyric acid, an inhibitory neurotransmitter, thus causing paralysis.  Mode of action Non-systemic insecticide which penetrates leaf tissues by translaminar movement. Paralyses the lepidoptera, which stop feeding within hours of ingestion, and die 2-4 dat.  Uses For control of Lepidoptera on vegetables, brassicas and cotton, at up to 16 g/ha, and in pine trees, at 5-25 g/ha. Formulation types EC; SG.  Selected products: 'Banlep' (); 'Denim' (); 'Proclaim' ()

ANALYSIS

Product and residues determined by hplc. Details available from .  

MAMMALIAN TOXICOLOGY

emamectin benzoate

Oral Acute oral LD50 for rats 76-89 mg/kg.  Skin and eye Acute dermal LD50 for rabbits >2000 mg/kg. It is not irritant to skin, and has no sensitising potential.  Inhalation LC50 (4 h) for rats 2.12-4.44 mg/m3.  NOEL (1 y) for dogs 0.25 mg/kg b.w.  ADI 0.0025 mg/kg.  Other Not tumorigenic.  Toxicity class WHO (a.i.) II (company classification)  

ECOTOXICOLOGY

emamectin benzoate

Birds Acute oral LD50 for mallard ducks 46, bobwhite quail 264 mg/kg. Dietary LC50 (8 d) for mallard ducks 570, bobwhite quail 1318 ppm.  Fish LC50 (96 h) for rainbow trout 174, sheepshead minnow 1430 mg/l.  Daphnia LC50 0.99 mg/l.  Bees Toxic to bees.  Worms LC50 >1000 mg/kg dry soil.  Other beneficial spp. Safe to a wide range of beneficial insects, due rapid breakdown of the a.i., limiting contact activity to <48 h.  

ENVIRONMENTAL FATE

Animals Emamectin benzoate is partially metabolised but rapidly cleared (DT50 following oral dosing 34-51 h), indicating that it has no potential for bioaccumulation.  Plants Metabolism has been investigated in lettuce, cabbage and sweet corn. It is non-systemic, and rapidly degrades in sunlight to various complex residues in which undegraded parent is the only significant residue. The residues were very low.  Soil/Environment Rapidly degraded.