Name | Baloxavir marboxil |
CAS number | 1985606-14-1 |
EINECS number | 606-227-7 |
Synonym | Baloxavir marboxil; S 033188; S-033188; S033188; Xofluza; ({(12aR)-12-[(11S)-7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl]-6,8-dioxo-3,4,6,8,12,12ahexahydro-1H-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazin-7-yl}oxy)methyl methyl carbonate |
Related CAS# | 1985605-59-1 (Baloxavir); 1985606-14-1 (marboxil) |
Description | Baloxavir marboxil, also known as S 033188, is a selective inhibitor of influenza cap-dependent endonuclease. It has shown therapeutic activity in preclinical models of influenza A and B virus infections, including strains resistant to current antiviral agents. |
Structure |  |
Molecular Formula | C27H23F2N3O7S |
Molecular Weight | 571.55 g/mol |
Appearance | Solid powder |
Quality Standard | Enterprise Standard |
Assay | ≥98% |
Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
Storage Condition | Store in cool place. Keep container tightly closed in a dry and well ventilated place. |
Shelf Life | >2 years if stored properly |
Sample package | Aluminium foil bag |
Commercial package | Aluminium Tin, Fiber drum |
Origin | China |
Baloxavir marboxil More Info
Baloxavir marboxil is an antiviral medication used for the treatment of influenza (the flu) in patients aged 12 years and older. It is a novel polymerase acidic endonuclease inhibitor that works by interfering with the replication of the influenza virus. Approved by the U.S. Food and Drug Administration (FDA) in 2018, baloxavir marboxil represents a new class of antiviral drugs for influenza.
Mechanism of Action
Baloxavir marboxil is a prodrug that is converted in the body to its active form, baloxavir, which inhibits the influenza virus's ability to replicate. The mechanism of action involves:
Inhibition of Viral RNA Polymerase: Baloxavir targets the endonuclease activity of the polymerase acidic (PA) protein of the influenza virus. By inhibiting this enzyme, baloxavir prevents the viral RNA from being cleaved and capped, which is essential for viral mRNA synthesis.
Blocking Viral Replication: This inhibition disrupts the replication cycle of the virus, ultimately leading to a reduction in viral load and alleviation of flu symptoms.
Applications
Baloxavir marboxil is indicated for:
Treatment of Influenza: It is used for the treatment of acute uncomplicated influenza in patients aged 12 years and older who have been symptomatic for no more than 48 hours.
Post-Exposure Prophylaxis: Baloxavir may also be used for post-exposure prophylaxis to prevent influenza infection in individuals who have been exposed to the virus.
Safety and Side Effects
Baloxavir marboxil is generally well-tolerated, but some side effects may occur:
Common Side Effects:
Diarrhea
Nausea
Headache
Bronchitis
Sinusitis
Serious Side Effects:
Hypersensitivity reactions (e.g., rash, itching, swelling)
Potential risk of developing viral resistance with improper use
Most side effects are mild to moderate and resolve without intervention.
Routes of Administration
Baloxavir marboxil is administered orally as a single dose tablet. It can be taken with or without food.
Pharmacokinetics
Absorption: Baloxavir marboxil is rapidly absorbed after oral administration, with peak plasma concentrations typically reached within 1-3 hours.
Distribution: The drug has a volume of distribution that indicates it distributes well throughout the body.
Metabolism: Baloxavir is primarily metabolized by uridine diphosphate-glucuronosyltransferases (UGTs), particularly UGT1A3.
Elimination: The elimination half-life of baloxavir is approximately 35 hours, allowing for once-daily dosing. The drug is primarily excreted via urine and feces.
Q1. Can I get a free sample?
We can send you a samll free sample, and you only need to pay for the shipping cost.
Q2. What is the HyperChem payment term?
T/T in advance
LC at sight
DP at sight
Bank transfer
PayPal
Bitcoin...
Q3. What is HyperChem shipment policy?
Our policy is to strive for the quickest shipment time possible.
For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.
Q4. What is HyperChem shipment term?
By Express
FedEx UPS DHL EMS
Fast: 3-7 days around, high cost, door to door service
By Air
Suitable for more than 50kg
Fast: 3-7 days, hight cost, port to port, professional broker needed
By Sea
Suitable for more than 500kg
Fast: 7-45 days, low cost, port to port, professional broker needed
We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.
Q5. What HyperChem will provide after shipment?
For sample orders:
After shipment is done, an timely email including:
1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice
For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.
Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.
Among them, our key client industrial sectors around the global are:
Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply
HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.
United States
Egypt
