ammonium chloride12125-02-9

Product Details of p - Nitrophenol as an Intermediate for Paracetamol

I. Product Overview

p - Nitrophenol, with the English name 4 - Nitrophenol, is an important organic synthesis intermediate. It plays an indispensable role in the pharmaceutical field, especially in the production process of paracetamol (acetaminophen). Its chemical structure is C₆H₅NO₃, and the molecular weight is 139.11.

II. Product Characteristics

Appearance: It is a light yellow or brown crystalline powder, which is stable at room temperature.

Physical Properties: The melting point is 113 - 114 °C. It is slightly soluble in cold water and easily soluble in hot water, ethanol, ether and other organic solvents. The difference in its solubility in different solvents provides convenience for subsequent separation, purification and reaction operations.

Chemical Properties: It has the typical chemical properties of phenolic hydroxyl and nitro groups. The phenolic hydroxyl group makes it have certain acidity and can react with bases to form phenol salts. The nitro group can be converted into an amino group through reduction and other reactions, laying the foundation for the synthesis of paracetamol.

III. Production Process

We adopt an advanced and mature synthesis process to produce p - nitrophenol. Using phenol as the starting material, it undergoes a nitration reaction with nitric acid under the action of catalysts such as sulfuric acid. The reaction process is precisely controlled in terms of temperature, pressure and material ratio to ensure efficient and selective production of p - nitrophenol, while minimizing the generation of by - products such as o - nitrophenol. After the reaction, through a series of separation and purification processes, including distillation, crystallization, recrystallization and other operations, a high - purity p - nitrophenol product is obtained, and the product purity can reach more than 99%.

IV. Quality Standards

We strictly follow relevant international and domestic quality standards to conduct a comprehensive inspection of the product. Our p - nitrophenol product performs excellently in key indicators such as content, impurity content and melting point. Specifically, the content is ≥ 99%, the content of impurities such as o - nitrophenol is ≤ 0.5%, and the melting point range is controlled at 113 - 114 °C, ensuring stable and reliable product quality to meet the high - standard quality requirements of pharmaceutical production enterprises.

V. Application Areas

As a key intermediate for paracetamol, p - nitrophenol is reduced to p - aminophenol, and then reacted with acetic anhydride to synthesize paracetamol. Paracetamol is a widely used antipyretic and analgesic drug globally, used to relieve various symptoms such as cold, fever, headache, and joint pain. In addition, p - nitrophenol also has certain applications in other fields such as medicine, dyes and pesticides. For example, it can be used to synthesize certain antibacterial drugs and dye molecules with specific structures.

VI. Packaging and Storage

Packaging: The product is packaged in 25 - kg cardboard drums, lined with double - layer plastic bags to ensure that the product is not affected by moisture or contaminated during transportation and storage, and is convenient for handling and use.

Storage: Store in a cool and ventilated warehouse. Keep away from fire sources, heat sources and avoid direct sunlight. It should be stored separately from oxidants, acids, alkalis, etc., and do not store them together. The storage area should be equipped with appropriate materials to contain leaks.

VII. Safety Information

p - Nitrophenol is toxic to a certain extent. Inhalation, ingestion or absorption through the skin may be harmful to the body. During the use process, operators should wear appropriate protective equipment, such as safety glasses, gloves, protective clothing, etc. In case of accidental contact, rinse immediately with plenty of water and seek medical attention in a timely manner. The transportation of the product needs to comply with the relevant regulations for the transportation of hazardous chemicals to ensure transportation safety.

We are committed to providing customers with high - quality p - nitrophenol products. If you have any needs or questions, please feel free to contact us, and we will serve you wholeheartedly.