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Mechanism of Action

Lincomycin inhibits bacterial protein synthesis by binding to the 23S ribosomal subunit, specifically within the peptidyl transferase loop region of the 23S rRNA. This action blocks the elongation of bacterial proteins, thereby exerting a bacteriostatic effect.

Medical Uses

Lincomycin is used to treat infections caused by Gram-positive bacteria, including:

Staphylococci (e.g., Staphylococcus aureus)

Streptococci (e.g., β-hemolytic streptococci)

Pneumococci (Streptococcus pneumoniae)

Clostridia.

It is particularly effective for:

Respiratory infections

Abdominal infections

Skin and soft tissue infections

Bone and joint infections (e.g., osteomyelitis).

Lincomycin is also used as an alternative for patients allergic to penicillin.

Pharmacokinetics

Administration: Available in oral, injectable, and intramuscular forms.

Absorption: Moderate oral absorption, with plasma protein binding around 75%.

Distribution: Widely distributed in tissues, including bone.

Excretion: Primarily excreted in urine and bile.

Storage Conditions

Lincomycin should be stored in a sealed container at 2-8°C.

Safety and Precautions

Side Effects: Common side effects include diarrhea, nausea, vomiting, and skin rash. Severe side effects may include pseudomembranous colitis, jaundice, and low blood cell counts.

Allergic Reactions: Immediate medical attention is required for signs of allergic reactions, such as hives, difficulty breathing, or swelling of the face or throat.

Antibiotic-Associated Diarrhea: Lincomycin can cause overgrowth of normally harmless bacteria in the intestines, leading to severe diarrhea. This condition can occur even months after treatment and requires prompt medical attention.

Conclusion

Lincomycin is a broad-spectrum antibiotic with significant activity against Gram-positive bacteria. While its use has decreased due to the availability of more potent derivatives like clindamycin, it remains an important option for treating severe infections, especially in penicillin-allergic patients.

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FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

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Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
FedEx  UPS  DHL  EMS                               
Fast: 3-7 days around, high cost, door to door service

By Air                                        
Suitable for more than 50kg 
Fast: 3-7 days, hight cost, port to port, professional broker needed 

By Sea
Suitable for more than 500kg      
Fast: 7-45 days, low cost, port to port, professional broker needed 

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders:
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.